A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3 '-UTR of dopamine transporter gene and attention deficit hyperactivity disorder

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	A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3 '-UTR of dopamine transporter gene and attention deficit hyperactivity disorder
	Yang, Binrang ; Chan, Raymond C. K.; Jing, Jin ; Li, Tao ; Sham, Pak ; Chen, Ronald Y. L.; C.K. Chan
摘要	The association between the 10-repeat allele of the dopamine transporter gene (DAT) and attention deficit hyperactivity disorder (ADHD) is uncertain. This study aimed to conduct a meta-analysis of the association between the 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism. in the 3'-untranslated region (UTR) of the DAT1 gene and ADHD. We pooled up 18 published transmission disequilibrium. test (TDT) studies between the 40-base pair VNTR polymorphism. in the3'-UTR of the DAT1 gene and ADHD. It included a total of 1,373 informative meioses, 7 haplotype-based haplotype relative risk (HHRR) studies, and 6 case-control-based association studies. There were statistically significant evidences for heterogeneity of the odds ratio in TDT and HHRR studies (P < 0.10), but not in case-control studies. The results of random effects model showed small but significant association between ADHD and the DAT1 gene in TDT studies (OR=1.17, 95% CI=1.05-1.30, chi-square = 8.11, df = 1, P = 0.004), but not in HHRR and case-control studies. The 10-repeat allele of a VNTR polymorphism. in the 3'-UTR the DAT1 gene has a small but significant role in the genetic susceptibility of ADHD. These meta-analysis findings support the involvement of the dopamine system genes in ADHD liability variation. However, more work is required to further identify the functional allelic variants/mutations that are responsible for this association.; The association between the 10-repeat allele of the dopamine transporter gene (DAT) and attention deficit hyperactivity disorder (ADHD) is uncertain. This study aimed to conduct a meta-analysis of the association between the 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism. in the 3'-untranslated region (UTR) of the DAT1 gene and ADHD. We pooled up 18 published transmission disequilibrium. test (TDT) studies between the 40-base pair VNTR polymorphism. in the3'-UTR of the DAT1 gene and ADHD. It included a total of 1,373 informative meioses, 7 haplotype-based haplotype relative risk (HHRR) studies, and 6 case-control-based association studies. There were statistically significant evidences for heterogeneity of the odds ratio in TDT and HHRR studies (P < 0.10), but not in case-control studies. The results of random effects model showed small but significant association between ADHD and the DAT1 gene in TDT studies (OR=1.17, 95% CI=1.05-1.30, chi-square = 8.11, df = 1, P = 0.004), but not in HHRR and case-control studies. The 10-repeat allele of a VNTR polymorphism. in the 3'-UTR the DAT1 gene has a small but significant role in the genetic susceptibility of ADHD. These meta-analysis findings support the involvement of the dopamine system genes in ADHD liability variation. However, more work is required to further identify the functional allelic variants/mutations that are responsible for this association. (c) 2007 Wiley-Liss, Inc.
关键词	ADHD TDT DAT
学科领域	变态心理学
	2007-06-05
语种	英语
发表期刊	AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
ISSN	1552-4841
卷号	144B 期号:4 页码:541-550
期刊论文类型	Review
收录类别	SCI
WOS记录号	WOS:000246982700022
引用统计	被引频次：139[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5123
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	C.K. Chan
作者单位	1.Sun Yat Sen Univ, Dept Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Guangzhou 510275, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100864, Peoples R China 3.Sun Yat Sen Univ, Dept Sociol, Guangzhou 510275, Peoples R China 4.Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou 510275, Peoples R China 5.Sichuan Univ, W China Hosp, Psychiat Lab, Chengdu 610064, Peoples R China 6.Sichuan Univ, W China Hosp, Dept Psychiat, Chengdu 610064, Peoples R China 7.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China 8.Inst Psychiat, Div Psychol Med, MRC SGDP Ctr, London, England
推荐引用方式 GB/T 7714	Yang, Binrang,Chan, Raymond C. K.,Jing, Jin,et al. A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3 '-UTR of dopamine transporter gene and attention deficit hyperactivity disorder[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2007,144B(4):541-550.
APA	Yang, Binrang.,Chan, Raymond C. K..,Jing, Jin.,Li, Tao.,Sham, Pak.,...&C.K. Chan.(2007).A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3 '-UTR of dopamine transporter gene and attention deficit hyperactivity disorder.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,144B(4),541-550.
MLA	Yang, Binrang,et al."A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3 '-UTR of dopamine transporter gene and attention deficit hyperactivity disorder".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 144B.4(2007):541-550.

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