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A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3 '-UTR of dopamine transporter gene and attention deficit hyperactivity disorder
Yang, Binrang; Chan, Raymond C. K.; Jing, Jin; Li, Tao; Sham, Pak; Chen, Ronald Y. L.; C.K. Chan
2007-06-05
Source PublicationAMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
ISSN1552-4841
SubtypeReview
Volume144BIssue:4Pages:541-550
AbstractThe association between the 10-repeat allele of the dopamine transporter gene (DAT) and attention deficit hyperactivity disorder (ADHD) is uncertain. This study aimed to conduct a meta-analysis of the association between the 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism. in the 3'-untranslated region (UTR) of the DAT1 gene and ADHD. We pooled up 18 published transmission disequilibrium. test (TDT) studies between the 40-base pair VNTR polymorphism. in the3'-UTR of the DAT1 gene and ADHD. It included a total of 1,373 informative meioses, 7 haplotype-based haplotype relative risk (HHRR) studies, and 6 case-control-based association studies. There were statistically significant evidences for heterogeneity of the odds ratio in TDT and HHRR studies (P < 0.10), but not in case-control studies. The results of random effects model showed small but significant association between ADHD and the DAT1 gene in TDT studies (OR=1.17, 95% CI=1.05-1.30, chi-square = 8.11, df = 1, P = 0.004), but not in HHRR and case-control studies. The 10-repeat allele of a VNTR polymorphism. in the 3'-UTR the DAT1 gene has a small but significant role in the genetic susceptibility of ADHD. These meta-analysis findings support the involvement of the dopamine system genes in ADHD liability variation. However, more work is required to further identify the functional allelic variants/mutations that are responsible for this association.; The association between the 10-repeat allele of the dopamine transporter gene (DAT) and attention deficit hyperactivity disorder (ADHD) is uncertain. This study aimed to conduct a meta-analysis of the association between the 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism. in the 3'-untranslated region (UTR) of the DAT1 gene and ADHD. We pooled up 18 published transmission disequilibrium. test (TDT) studies between the 40-base pair VNTR polymorphism. in the3'-UTR of the DAT1 gene and ADHD. It included a total of 1,373 informative meioses, 7 haplotype-based haplotype relative risk (HHRR) studies, and 6 case-control-based association studies. There were statistically significant evidences for heterogeneity of the odds ratio in TDT and HHRR studies (P < 0.10), but not in case-control studies. The results of random effects model showed small but significant association between ADHD and the DAT1 gene in TDT studies (OR=1.17, 95% CI=1.05-1.30, chi-square = 8.11, df = 1, P = 0.004), but not in HHRR and case-control studies. The 10-repeat allele of a VNTR polymorphism. in the 3'-UTR the DAT1 gene has a small but significant role in the genetic susceptibility of ADHD. These meta-analysis findings support the involvement of the dopamine system genes in ADHD liability variation. However, more work is required to further identify the functional allelic variants/mutations that are responsible for this association. (c) 2007 Wiley-Liss, Inc.
KeywordADHD TDT DAT
Subject Area变态心理学
Indexed BySCI
Language英语
WOS IDWOS:000246982700022
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5123
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorC.K. Chan
Affiliation1.Sun Yat Sen Univ, Dept Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Guangzhou 510275, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100864, Peoples R China
3.Sun Yat Sen Univ, Dept Sociol, Guangzhou 510275, Peoples R China
4.Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou 510275, Peoples R China
5.Sichuan Univ, W China Hosp, Psychiat Lab, Chengdu 610064, Peoples R China
6.Sichuan Univ, W China Hosp, Dept Psychiat, Chengdu 610064, Peoples R China
7.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
8.Inst Psychiat, Div Psychol Med, MRC SGDP Ctr, London, England
Recommended Citation
GB/T 7714
Yang, Binrang,Chan, Raymond C. K.,Jing, Jin,et al. A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3 '-UTR of dopamine transporter gene and attention deficit hyperactivity disorder[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2007,144B(4):541-550.
APA Yang, Binrang.,Chan, Raymond C. K..,Jing, Jin.,Li, Tao.,Sham, Pak.,...&C.K. Chan.(2007).A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3 '-UTR of dopamine transporter gene and attention deficit hyperactivity disorder.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,144B(4),541-550.
MLA Yang, Binrang,et al."A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3 '-UTR of dopamine transporter gene and attention deficit hyperactivity disorder".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 144B.4(2007):541-550.
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