A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods

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	A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods
	Kong, JA ; Ma, L; Gollub, RL ; Wei, JH ; Yang, XZ ; Li, DJ ; Weng, XC; Jia, FC ; Wang, CM ; Li, FL ; Li, RW ; Zhuang, D ; J. A. Kong
摘要	Objectives: To characterize the brain activation patterns evoked by manual and electroacupuncture on normal human subjects.Design: We used functional magnetic resonance imaging (fMRI) to investigate the brain regions involved in electroacupuncture and manual acupuncture needle stimulation. A block design was adopted for the study. Each functional run consists of 5 minutes, starting with 1-minute baseline and two 1-minute stimulation, the interval between the two stimuli was 1 minute. Four functional runs were performed on each subject, two runs for electroacupuncture and two runs for manual acupuncture. The order of the two modalities was randomized among subjects. During the experiment, acupuncture needle manipulation was performed at Large Intestine 4 (LI4, Hegu) on the left hand. For each subject, before scanning started, the needle was inserted perpendicular to the skin surface to a depth of approximately 1.0 cm. Electroacupuncture stimulation was delivered using a continuous rectangular wave form (pulse width 30 ms) at a frequency of 3 Hz. For manual acupuncture, the needle was rotated manually clockwise and counterclockwise at a rate of about 180 times per minute (3 Hz).Subjects: Eleven right-handed, normal, healthy volunteer adults, 6 male and 5 female, ages 21-64 participated in the experiment.Results: Results showed that electroacupuncture mainly produced fMRI signal increases in precentral gyrus, postcentral gyrus/inferior parietal lobule, and putamen/insula; in contrast, manual needle manipulation produced prominent decreases of fMRI signals in posterior cingulate, superior temporal gyrus, putamen/insula.Conclusion: These results indicate that different brain networks are involved during manual and electroacupuncture stimulation. It suggests that different brain mechanisms may be recruited during manual and electroacupuncture.; Objectives: To characterize the brain activation patterns evoked by manual and electroacupuncture on normal human subjects.
关键词	united-states acupoints medicine
学科领域	生理心理学/生物心理学
	2002-08-01
语种	英语
发表期刊	JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
ISSN	1075-5535
卷号	8 期号:4 页码:411-419
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000177855600005
引用统计	被引频次：129[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5135
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	J. A. Kong
作者单位	1.Massachusetts Gen Hosp E, Dept Psychiat, Charlestown, MA 02129 USA 2.Chinese Acad Tradit Chinese Med, Inst Acupuncture & Moxibust, Beijing, Peoples R China 3.Harvard Univ, Sch Med, Boston, MA USA 4.Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 6.Capital Moral Univ, Dept Phys, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Kong, JA,Ma, L,Gollub, RL,et al. A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods[J]. JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE,2002,8(4):411-419.
APA	Kong, JA.,Ma, L.,Gollub, RL.,Wei, JH.,Yang, XZ.,...&J. A. Kong.(2002).A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods.JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE,8(4),411-419.
MLA	Kong, JA,et al."A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods".JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE 8.4(2002):411-419.

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