A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods
Kong, JA; Ma, L; Gollub, RL; Wei, JH; Yang, XZ; Li, DJ; Weng, XC; Jia, FC; Wang, CM; Li, FL; Li, RW; Zhuang, D; J. A. Kong
2002-08-01
发表期刊JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
ISSN1075-5535
文章类型Article
卷号8期号:4页码:411-419
摘要Objectives: To characterize the brain activation patterns evoked by manual and electroacupuncture on normal human subjects.Design: We used functional magnetic resonance imaging (fMRI) to investigate the brain regions involved in electroacupuncture and manual acupuncture needle stimulation. A block design was adopted for the study. Each functional run consists of 5 minutes, starting with 1-minute baseline and two 1-minute stimulation, the interval between the two stimuli was 1 minute. Four functional runs were performed on each subject, two runs for electroacupuncture and two runs for manual acupuncture. The order of the two modalities was randomized among subjects. During the experiment, acupuncture needle manipulation was performed at Large Intestine 4 (LI4, Hegu) on the left hand. For each subject, before scanning started, the needle was inserted perpendicular to the skin surface to a depth of approximately 1.0 cm. Electroacupuncture stimulation was delivered using a continuous rectangular wave form (pulse width 30 ms) at a frequency of 3 Hz. For manual acupuncture, the needle was rotated manually clockwise and counterclockwise at a rate of about 180 times per minute (3 Hz).Subjects: Eleven right-handed, normal, healthy volunteer adults, 6 male and 5 female, ages 21-64 participated in the experiment.Results: Results showed that electroacupuncture mainly produced fMRI signal increases in precentral gyrus, postcentral gyrus/inferior parietal lobule, and putamen/insula; in contrast, manual needle manipulation produced prominent decreases of fMRI signals in posterior cingulate, superior temporal gyrus, putamen/insula.Conclusion: These results indicate that different brain networks are involved during manual and electroacupuncture stimulation. It suggests that different brain mechanisms may be recruited during manual and electroacupuncture.; Objectives: To characterize the brain activation patterns evoked by manual and electroacupuncture on normal human subjects.
关键词united-states acupoints medicine
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000177855600005
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5135
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者J. A. Kong
作者单位1.Massachusetts Gen Hosp E, Dept Psychiat, Charlestown, MA 02129 USA
2.Chinese Acad Tradit Chinese Med, Inst Acupuncture & Moxibust, Beijing, Peoples R China
3.Harvard Univ, Sch Med, Boston, MA USA
4.Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
6.Capital Moral Univ, Dept Phys, Beijing, Peoples R China
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Kong, JA,Ma, L,Gollub, RL,et al. A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods[J]. JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE,2002,8(4):411-419.
APA Kong, JA.,Ma, L.,Gollub, RL.,Wei, JH.,Yang, XZ.,...&J. A. Kong.(2002).A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods.JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE,8(4),411-419.
MLA Kong, JA,et al."A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods".JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE 8.4(2002):411-419.
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