A regulation role of the prefrontal cortex in the Fist-Edge-Palm task: Evidence from functional connectivity analysis
Rao, Hengyi1,3,4; Di, Xin3; Chan, Raymond C. K.3,5,6; Ding, Yulong3; Ye, Binbin3; Gao, Dingguo3; H. Rao
2008-07-15
发表期刊NEUROIMAGE
ISSN1053-8119
文章类型Article
卷号41期号:4页码:1345-1351
摘要The Fist-Edge-Palm (FEP) task is a motor sequencing task that is widely used in neurological examination. Deficits in this task are believed to reflect impairment in the frontal lobe regions. However, two recent functional brain imaging studies of the FEP task using conventional subtraction analysis failed to demonstrate FEP-induced activation in the prefrontal cortex (PFC), which contradicts existing neuropsychological literature. In this study, psychophysiological interaction (PPI) analysis was used to reanalyze our previous neuroimaging dataset from 10 healthy subjects in order to evaluate the changes of functional connectivity between the sensorimotor cortex and the prefrontal regions during the performances of the FEP task relative to simple motor control tasks. The PPI analysis revealed significantly increased functional connectivity between bilateral sensorimotor cortex and the right inferior and middle frontal cortex during the performance of the FEP task compared with the control tasks. However, regional signal changes showed no significant activation differences in these prefrontal regions. These results provide evidence supporting the involvement of the frontal lobe in the performance of the FEP task, and suggest a role of regulation, rather than direct participation, of the prefrontal cortex in the execution of complex motor sequence tasks such as the FEP task.; The Fist-Edge-Palm (FEP) task is a motor sequencing task that is widely used in neurological examination. Deficits in this task are believed to reflect impairment in the frontal lobe regions. However, two recent functional brain imaging studies of the FEP task using conventional subtraction analysis failed to demonstrate FEP-induced activation in the prefrontal cortex (PFC), which contradicts existing neuropsychological literature. In this study, psychophysiological interaction (PPI) analysis was used to reanalyze our previous neuroimaging dataset from 10 healthy subjects in order to evaluate the changes of functional connectivity between the sensorimotor cortex and the prefrontal regions during the performances of the FEP task relative to simple motor control tasks. The PPI analysis revealed significantly increased functional connectivity between bilateral sensorimotor cortex and the right inferior and middle frontal cortex during the performance of the FEP task compared with the control tasks. However, regional signal changes showed no significant activation differences in these prefrontal regions. These results provide evidence supporting the involvement of the frontal lobe in the performance of the FEP task, and suggest a role of regulation, rather than direct participation, of the prefrontal cortex in the execution of complex motor sequence tasks such as the FEP task. (c) 2008 Elsevier Inc. All rights reserved.
关键词motor sequencing Fist-Edge-Palm effective connectivity prefrontal cortex
学科领域生理心理学/生物心理学
收录类别SCI ; SSCI
语种英语
WOS记录号WOS:000256620400016
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5141
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者H. Rao
作者单位1.Univ Penn, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USA
2.Sun Yat Sen Univ, Dept Psychol, Ctr Funct Brain Imaging, Guangzhou 510275, Peoples R China
3.Sun Yat Sen Univ, First Affiliated Hosp, Guangzhou 510275, Peoples R China
4.Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Rao, Hengyi,Di, Xin,Chan, Raymond C. K.,et al. A regulation role of the prefrontal cortex in the Fist-Edge-Palm task: Evidence from functional connectivity analysis[J]. NEUROIMAGE,2008,41(4):1345-1351.
APA Rao, Hengyi.,Di, Xin.,Chan, Raymond C. K..,Ding, Yulong.,Ye, Binbin.,...&H. Rao.(2008).A regulation role of the prefrontal cortex in the Fist-Edge-Palm task: Evidence from functional connectivity analysis.NEUROIMAGE,41(4),1345-1351.
MLA Rao, Hengyi,et al."A regulation role of the prefrontal cortex in the Fist-Edge-Palm task: Evidence from functional connectivity analysis".NEUROIMAGE 41.4(2008):1345-1351.
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