PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
A regulation role of the prefrontal cortex in the Fist-Edge-Palm task: Evidence from functional connectivity analysis
Rao, Hengyi1,3,4; Di, Xin3; Chan, Raymond C. K.3,5,6; Ding, Yulong3; Ye, Binbin3; Gao, Dingguo3; H. Rao
2008-07-15
Source PublicationNEUROIMAGE
ISSN1053-8119
SubtypeArticle
Volume41Issue:4Pages:1345-1351
AbstractThe Fist-Edge-Palm (FEP) task is a motor sequencing task that is widely used in neurological examination. Deficits in this task are believed to reflect impairment in the frontal lobe regions. However, two recent functional brain imaging studies of the FEP task using conventional subtraction analysis failed to demonstrate FEP-induced activation in the prefrontal cortex (PFC), which contradicts existing neuropsychological literature. In this study, psychophysiological interaction (PPI) analysis was used to reanalyze our previous neuroimaging dataset from 10 healthy subjects in order to evaluate the changes of functional connectivity between the sensorimotor cortex and the prefrontal regions during the performances of the FEP task relative to simple motor control tasks. The PPI analysis revealed significantly increased functional connectivity between bilateral sensorimotor cortex and the right inferior and middle frontal cortex during the performance of the FEP task compared with the control tasks. However, regional signal changes showed no significant activation differences in these prefrontal regions. These results provide evidence supporting the involvement of the frontal lobe in the performance of the FEP task, and suggest a role of regulation, rather than direct participation, of the prefrontal cortex in the execution of complex motor sequence tasks such as the FEP task.; The Fist-Edge-Palm (FEP) task is a motor sequencing task that is widely used in neurological examination. Deficits in this task are believed to reflect impairment in the frontal lobe regions. However, two recent functional brain imaging studies of the FEP task using conventional subtraction analysis failed to demonstrate FEP-induced activation in the prefrontal cortex (PFC), which contradicts existing neuropsychological literature. In this study, psychophysiological interaction (PPI) analysis was used to reanalyze our previous neuroimaging dataset from 10 healthy subjects in order to evaluate the changes of functional connectivity between the sensorimotor cortex and the prefrontal regions during the performances of the FEP task relative to simple motor control tasks. The PPI analysis revealed significantly increased functional connectivity between bilateral sensorimotor cortex and the right inferior and middle frontal cortex during the performance of the FEP task compared with the control tasks. However, regional signal changes showed no significant activation differences in these prefrontal regions. These results provide evidence supporting the involvement of the frontal lobe in the performance of the FEP task, and suggest a role of regulation, rather than direct participation, of the prefrontal cortex in the execution of complex motor sequence tasks such as the FEP task. (c) 2008 Elsevier Inc. All rights reserved.
Keywordmotor sequencing Fist-Edge-Palm effective connectivity prefrontal cortex
Subject Area生理心理学/生物心理学
Indexed BySCI ; SSCI
Language英语
WOS IDWOS:000256620400016
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5141
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorH. Rao
Affiliation1.Univ Penn, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USA
2.Sun Yat Sen Univ, Dept Psychol, Ctr Funct Brain Imaging, Guangzhou 510275, Peoples R China
3.Sun Yat Sen Univ, First Affiliated Hosp, Guangzhou 510275, Peoples R China
4.Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Rao, Hengyi,Di, Xin,Chan, Raymond C. K.,et al. A regulation role of the prefrontal cortex in the Fist-Edge-Palm task: Evidence from functional connectivity analysis[J]. NEUROIMAGE,2008,41(4):1345-1351.
APA Rao, Hengyi.,Di, Xin.,Chan, Raymond C. K..,Ding, Yulong.,Ye, Binbin.,...&H. Rao.(2008).A regulation role of the prefrontal cortex in the Fist-Edge-Palm task: Evidence from functional connectivity analysis.NEUROIMAGE,41(4),1345-1351.
MLA Rao, Hengyi,et al."A regulation role of the prefrontal cortex in the Fist-Edge-Palm task: Evidence from functional connectivity analysis".NEUROIMAGE 41.4(2008):1345-1351.
Files in This Item:
File Name/Size DocType Version Access License
Rao-2008-A regulatio(308KB) 限制开放--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Rao, Hengyi]'s Articles
[Di, Xin]'s Articles
[Chan, Raymond C. K.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Rao, Hengyi]'s Articles
[Di, Xin]'s Articles
[Chan, Raymond C. K.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Rao, Hengyi]'s Articles
[Di, Xin]'s Articles
[Chan, Raymond C. K.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Rao-2008-A regulation role of.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.