Activation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts

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	Activation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts
	Liu, Sheng ; Zhou, Wenhua ; Ruan, Xingzhong ; Li, Ronghui ; Lee, Tatia ; Weng, Xuchu; Hu, Jun ; Yang, Guodong ; W. H. Zhou
摘要	Acupuncture stimulation elicited a composite of sensations termed deqi that is related to clinical efficacy. Neurobiological studies have identified the hypothalamus as an important component in mediating the deqi. Functional changes in hypothalamus persist after abstinence in addicts. We investigated the activation in the hypothalamus associated with acupuncture stimulation in healthy volunteers and heroin addicts by fMRI. Cortisol level and psychophysical responses, including the deqi sensation (an acupuncture effect of needle-manipulation), anxiety, and sharp pain, were also assessed. The activation of the hypothalamus was more robust in the addicts than that in the healthy subjects during acupuncture stimulation. The deqi scores of the heroin addicts were significantly higher than those of the healthy subjects during acupuncture treatment. An acupuncture sensation scale predicted the activation of the hypothalamus associated with the deqi sensation.; Acupuncture stimulation elicited a composite of sensations termed deqi that is related to clinical efficacy. Neurobiological studies have identified the hypothalamus as an important component in mediating the deqi. Functional changes in hypothalamus persist after abstinence in addicts. We investigated the activation in the hypothalamus associated with acupuncture stimulation in healthy volunteers and heroin addicts by fMRI. Cortisol level and psychophysical responses, including the deqi sensation (an acupuncture effect of needle-manipulation), anxiety, and sharp pain, were also assessed. The activation of the hypothalamus was more robust in the addicts than that in the healthy subjects during acupuncture stimulation. The deqi scores of the heroin addicts were significantly higher than those of the healthy subjects during acupuncture treatment. An acupuncture sensation scale predicted the activation of the hypothalamus associated with the deqi sensation. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
关键词	acupuncture hypothalamus cortisol heroin addicts
学科领域	生理心理学/生物心理学
	2007-06-29
语种	英语
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	421 期号:3 页码:203-208
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000248152100004
引用统计	被引频次：37[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5153
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	W. H. Zhou
作者单位	1.Ningbo Addict Res & Treatment Ctr, Ningbo, Peoples R China 2.Ningbo First Peoples Hosp, Dept MRI, Ningbo 315010, Peoples R China 3.Univ Hong Kong, Neuropsychol Lab, Hong Kong, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Beijing 100864, Peoples R China 5.Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Liu, Sheng,Zhou, Wenhua,Ruan, Xingzhong,et al. Activation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts[J]. NEUROSCIENCE LETTERS,2007,421(3):203-208.
APA	Liu, Sheng.,Zhou, Wenhua.,Ruan, Xingzhong.,Li, Ronghui.,Lee, Tatia.,...&W. H. Zhou.(2007).Activation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts.NEUROSCIENCE LETTERS,421(3),203-208.
MLA	Liu, Sheng,et al."Activation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts".NEUROSCIENCE LETTERS 421.3(2007):203-208.

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