Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice
Xu, Qiang2; Guo, Jianyou1; J. Y. Guo
2009-12-01
发表期刊BIOLOGICAL TRACE ELEMENT RESEARCH
ISSN0163-4984
文章类型Article
卷号131期号:3页码:271-277
摘要This study was designed to evaluate the effect of administration of chromium-enriched Grifola frondosa (CEGF) in insulin-resistant sucrose-fed mice. Mice were randomly assigned to be unsupplemented (S group) or to receive oral CEGF at a dose of 0.5, 1.0, 2.0, 3.0, 4.0, and 5.0 mg/kg per day chromium. A control group (C) did not consume sucrose and was not supplemented. Sucrose-fed mice had an elevated serum insulin concentration compared with controls and this was significantly lower in sucrose-fed mice that received CEGF (4.0 and 5.0 mg/kg per day chromium), which did not differ from controls. Impaired glucose tolerance in sucrose-fed mice, evidenced by the poor glucose disposal rate following an intraperitoneal glucose tolerance test, was significantly improved in mice receiving CEGF. CEGF is essentially nontoxic at the dose of 4.0 and 5.0 mg/kg per day. These results indicate that CEGF may have potential beneficial effects in insulin-resistant prediabetic conditions.; This study was designed to evaluate the effect of administration of chromium-enriched Grifola frondosa (CEGF) in insulin-resistant sucrose-fed mice. Mice were randomly assigned to be unsupplemented (S group) or to receive oral CEGF at a dose of 0.5, 1.0, 2.0, 3.0, 4.0, and 5.0 mg/kg per day chromium. A control group (C) did not consume sucrose and was not supplemented. Sucrose-fed mice had an elevated serum insulin concentration compared with controls and this was significantly lower in sucrose-fed mice that received CEGF (4.0 and 5.0 mg/kg per day chromium), which did not differ from controls. Impaired glucose tolerance in sucrose-fed mice, evidenced by the poor glucose disposal rate following an intraperitoneal glucose tolerance test, was significantly improved in mice receiving CEGF. CEGF is essentially nontoxic at the dose of 4.0 and 5.0 mg/kg per day. These results indicate that CEGF may have potential beneficial effects in insulin-resistant prediabetic conditions.
关键词Chromium Grifola frondosa Glucose tolerance Insulin Organ masses
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000271396500007
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5155
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者J. Y. Guo
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Sichuan Univ, Dept Prosthodont, W China Coll Stomatol, Chengdu 610041, Peoples R China
推荐引用方式
GB/T 7714
Xu, Qiang,Guo, Jianyou,J. Y. Guo. Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2009,131(3):271-277.
APA Xu, Qiang,Guo, Jianyou,&J. Y. Guo.(2009).Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice.BIOLOGICAL TRACE ELEMENT RESEARCH,131(3),271-277.
MLA Xu, Qiang,et al."Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice".BIOLOGICAL TRACE ELEMENT RESEARCH 131.3(2009):271-277.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Xu-2009-Activity and(123KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Qiang]的文章
[Guo, Jianyou]的文章
[J. Y. Guo]的文章
百度学术
百度学术中相似的文章
[Xu, Qiang]的文章
[Guo, Jianyou]的文章
[J. Y. Guo]的文章
必应学术
必应学术中相似的文章
[Xu, Qiang]的文章
[Guo, Jianyou]的文章
[J. Y. Guo]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Xu-2009-Activity and Toxicity .pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。