Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice
	Xu, Qiang 2; Guo, Jianyou1 ; J. Y. Guo
摘要	This study was designed to evaluate the effect of administration of chromium-enriched Grifola frondosa (CEGF) in insulin-resistant sucrose-fed mice. Mice were randomly assigned to be unsupplemented (S group) or to receive oral CEGF at a dose of 0.5, 1.0, 2.0, 3.0, 4.0, and 5.0 mg/kg per day chromium. A control group (C) did not consume sucrose and was not supplemented. Sucrose-fed mice had an elevated serum insulin concentration compared with controls and this was significantly lower in sucrose-fed mice that received CEGF (4.0 and 5.0 mg/kg per day chromium), which did not differ from controls. Impaired glucose tolerance in sucrose-fed mice, evidenced by the poor glucose disposal rate following an intraperitoneal glucose tolerance test, was significantly improved in mice receiving CEGF. CEGF is essentially nontoxic at the dose of 4.0 and 5.0 mg/kg per day. These results indicate that CEGF may have potential beneficial effects in insulin-resistant prediabetic conditions.; This study was designed to evaluate the effect of administration of chromium-enriched Grifola frondosa (CEGF) in insulin-resistant sucrose-fed mice. Mice were randomly assigned to be unsupplemented (S group) or to receive oral CEGF at a dose of 0.5, 1.0, 2.0, 3.0, 4.0, and 5.0 mg/kg per day chromium. A control group (C) did not consume sucrose and was not supplemented. Sucrose-fed mice had an elevated serum insulin concentration compared with controls and this was significantly lower in sucrose-fed mice that received CEGF (4.0 and 5.0 mg/kg per day chromium), which did not differ from controls. Impaired glucose tolerance in sucrose-fed mice, evidenced by the poor glucose disposal rate following an intraperitoneal glucose tolerance test, was significantly improved in mice receiving CEGF. CEGF is essentially nontoxic at the dose of 4.0 and 5.0 mg/kg per day. These results indicate that CEGF may have potential beneficial effects in insulin-resistant prediabetic conditions.
关键词	Chromium Grifola frondosa Glucose tolerance Insulin Organ masses
学科领域	生理心理学/生物心理学
	2009-12-01
语种	英语
发表期刊	BIOLOGICAL TRACE ELEMENT RESEARCH
ISSN	0163-4984
卷号	131 期号:3 页码:271-277
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000271396500007
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/5155
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	J. Y. Guo
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Sichuan Univ, Dept Prosthodont, W China Coll Stomatol, Chengdu 610041, Peoples R China
推荐引用方式 GB/T 7714	Xu, Qiang,Guo, Jianyou,J. Y. Guo. Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2009,131(3):271-277.
APA	Xu, Qiang,Guo, Jianyou,&J. Y. Guo.(2009).Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice.BIOLOGICAL TRACE ELEMENT RESEARCH,131(3),271-277.
MLA	Xu, Qiang,et al."Activity and Toxicity of Cr(III)-Enriched Grifola frondosa in Insulin-Resistant Mice".BIOLOGICAL TRACE ELEMENT RESEARCH 131.3(2009):271-277.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Xu-2009-Activity and（123KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载