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Acute Psychological Stress Reduces Working Memory-Related Activity in the Dorsolateral Prefrontal Cortex
Qin, Shaozheng1,2; Hermans, Erno J.1,2; van Marle, Hein J. F.1,2; Luo, Jing3; Fernandez, Guillen1,2
2009-07-01
Source PublicationBIOLOGICAL PSYCHIATRY
ISSN0006-3223
SubtypeArticle
Volume66Issue:1Pages:25-32
AbstractBackground: Acute psychological stress impairs higher-order cognitive function such as working memory (WM). Similar impairments are seen in various psychiatric disorders that are associated with higher susceptibility to stress and with prefrontal cortical dysfunctions, suggesting that acute stress may play a potential role in such dysfunctions. However, it remains unknown whether acute stress has immediate effects on WM-related prefrontal activity. Methods: Using functional magnetic resonance imaging (fMRI), we investigated neural activity of 27 healthy female participants during a blocked WM task (numerical N-back) while moderate psychological stress was induced by viewing strongly aversive (vs. neutral) movie material together with a self-referencing instruction. To assess stress manipulation, autonomic and endocrine, as well as subjective, measurements were acquired throughout the experiment. Results: Successfully induced acute stress resulted in significantly reduced WM-related activity in the dorsolateral prefrontal cortex (DLPFC), and was accompanied by less deactivation in brain regions that are jointly referred to as the default mode network. Conclusions: This study demonstrates that experimentally induced acute stress in healthy volunteers results in a reduction of WM-related DLPFC activity and reallocation of neural resources away from executive function networks. These effects may be explained by supraoptimal levels of catecholamines potentially in conjunction with elevated levels of cortisol. A similar mechanism involving acute stress as a mediating factor may play an important role in higher-order cognitive deficits and hypofrontality observed in various psychiatric disorders.; Background: Acute psychological stress impairs higher-order cognitive function such as working memory (WM). Similar impairments are seen in various psychiatric disorders that are associated with higher susceptibility to stress and with prefrontal cortical dysfunctions, suggesting that acute stress may play a potential role in such dysfunctions. However, it remains unknown whether acute stress has immediate effects on WM-related prefrontal activity.
KeywordDorsolateral prefrontal cortex fMRI psychological stress working memory
Subject Area生理心理学/生物心理学 ; 健康心理学
Indexed BySCI
Language英语
WOS IDWOS:000267469900005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5159
Collection中国科学院心理研究所回溯数据库(1956-2010)
Affiliation1.Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behaviour, Ctr Cognit Neuroimaging, NL-6500 HB Nijmegen, Netherlands
2.Radboud Univ Nijmegen, Dept Neurol, Med Ctr, NL-6500 HB Nijmegen, Netherlands
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Qin, Shaozheng,Hermans, Erno J.,van Marle, Hein J. F.,et al. Acute Psychological Stress Reduces Working Memory-Related Activity in the Dorsolateral Prefrontal Cortex[J]. BIOLOGICAL PSYCHIATRY,2009,66(1):25-32.
APA Qin, Shaozheng,Hermans, Erno J.,van Marle, Hein J. F.,Luo, Jing,&Fernandez, Guillen.(2009).Acute Psychological Stress Reduces Working Memory-Related Activity in the Dorsolateral Prefrontal Cortex.BIOLOGICAL PSYCHIATRY,66(1),25-32.
MLA Qin, Shaozheng,et al."Acute Psychological Stress Reduces Working Memory-Related Activity in the Dorsolateral Prefrontal Cortex".BIOLOGICAL PSYCHIATRY 66.1(2009):25-32.
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