Analysis of the relationship between three coding polymorphisms in LEPR gene and obesity in northern Chinese
Qu, Yanchun2,3; Yang, Ze3; Jin, Feng4; Sun, Liang3; Zhang, Chuanfang; Sun, Hong5; Wang, Binyou5; Wang, Li1; Z. Yang; L.Wang
2007-12-01
发表期刊OBESITY RESEARCH & CLINICAL PRACTICE
ISSN1871-403X
文章类型Article
卷号1期号:4页码:261-266
摘要To determine the effect of variants in LEPR gene on obesity in northern Chinese, three coding polymorphisms Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were investigated for association with overweight and obesity. By a case control design, 248 overweight or obese subjects and 351 lean normal controls were recruited in Harbin region in north China. All three polymorphisms were genotyped by Sequenom single nucleotide polymorphism (SNP) detection system in both cases and controls. Genotypes for all three polymorphisms were in Hardy–Weinberg equilibrium in control subjects. Both groups had similar distribution of alleles and genotypes created by the three coding polymorphisms of LEPR gene. No differences in frequencies of genotypes or alleles between cases and controls for any polymorphism individually were found by χ2 analysis (p = 0.444, p = 0.507 and p = 0.662, respectively). Further, when the haplotypes of three polymorphisms were assessed, no association for any haplotype of three polymorphisms was revealed. In the present study, the three coding polymorphisms in LEPR gene were firstly investigated in a population of northern Chinese. It was suggested that the three coding polymorphisms in LEPR gene were unlikely to have major effects on susceptibility to obesity in northern Chinese.; To determine the effect of variants in LEPR gene on obesity in northern Chinese, three coding polymorphisms Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were investigated for association with overweight and obesity. By a case control design, 248 overweight or obese subjects and 351 lean normal controls were recruited in Harbin region in north China. All three polymorphisms were genotyped by Sequenom single nucleotide polymorphism (SNP) detection system in both cases and controls. Genotypes for all three polymorphisms were in Hardy-Weinberg equilibrium in control subjects. Both groups had similar distribution of alleles and genotypes created by the three coding polymorphisms of LEPR gene. No differences in frequencies of genotypes or alleles between cases and controls for any polymorphism individually were found by chi(2) analysis (p=0.444, p=0.507 and p=0.662, respectively). Further, when the haplotypes of three polymorphisms were assessed, no association for any haplotype of three polymorphisms was revealed. In the present study, the three coding polymorphisms in LEPR gene were firstly investigated in a population of northern Chinese. It was suggested that the three coding polymorphisms in LEPR gene were unlikely to have major effects on susceptibility to obesity in northern Chinese. (c) 2007 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
关键词LEPR gene Obesity Case control study Haplotype
学科领域遗传学
收录类别SCI
语种英语
WOS记录号WOS:000206062000005
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5183
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Z. Yang; L.Wang
作者单位1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Human & Anim Genet, Grad Sch, Beijing 100101, Peoples R China
2.Tianjin Med Univ, Second Hosp, Tianjin Inst Urol, Tianjin 30021, Peoples R China
3.Beijing Hosp, Natl Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
5.Harbin Med Coll, Sch Publ Hlth, Harbin 150081, Peoples R China
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Qu, Yanchun,Yang, Ze,Jin, Feng,et al. Analysis of the relationship between three coding polymorphisms in LEPR gene and obesity in northern Chinese[J]. OBESITY RESEARCH & CLINICAL PRACTICE,2007,1(4):261-266.
APA Qu, Yanchun.,Yang, Ze.,Jin, Feng.,Sun, Liang.,Zhang, Chuanfang.,...&L.Wang.(2007).Analysis of the relationship between three coding polymorphisms in LEPR gene and obesity in northern Chinese.OBESITY RESEARCH & CLINICAL PRACTICE,1(4),261-266.
MLA Qu, Yanchun,et al."Analysis of the relationship between three coding polymorphisms in LEPR gene and obesity in northern Chinese".OBESITY RESEARCH & CLINICAL PRACTICE 1.4(2007):261-266.
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