Analysis of the relationship between three coding polymorphisms in LEPR gene and obesity in northern Chinese

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Analysis of the relationship between three coding polymorphisms in LEPR gene and obesity in northern Chinese
	Qu, Yanchun 2,3; Yang, Ze 3; Jin, Feng4 ; Sun, Liang 3; Zhang, Chuanfang ; Sun, Hong 5; Wang, Binyou 5; Wang, Li1 ; Z. Yang ; L.Wang
摘要	To determine the effect of variants in LEPR gene on obesity in northern Chinese, three coding polymorphisms Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were investigated for association with overweight and obesity. By a case control design, 248 overweight or obese subjects and 351 lean normal controls were recruited in Harbin region in north China. All three polymorphisms were genotyped by Sequenom single nucleotide polymorphism (SNP) detection system in both cases and controls. Genotypes for all three polymorphisms were in Hardy–Weinberg equilibrium in control subjects. Both groups had similar distribution of alleles and genotypes created by the three coding polymorphisms of LEPR gene. No differences in frequencies of genotypes or alleles between cases and controls for any polymorphism individually were found by χ2 analysis (p = 0.444, p = 0.507 and p = 0.662, respectively). Further, when the haplotypes of three polymorphisms were assessed, no association for any haplotype of three polymorphisms was revealed. In the present study, the three coding polymorphisms in LEPR gene were firstly investigated in a population of northern Chinese. It was suggested that the three coding polymorphisms in LEPR gene were unlikely to have major effects on susceptibility to obesity in northern Chinese.; To determine the effect of variants in LEPR gene on obesity in northern Chinese, three coding polymorphisms Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were investigated for association with overweight and obesity. By a case control design, 248 overweight or obese subjects and 351 lean normal controls were recruited in Harbin region in north China. All three polymorphisms were genotyped by Sequenom single nucleotide polymorphism (SNP) detection system in both cases and controls. Genotypes for all three polymorphisms were in Hardy-Weinberg equilibrium in control subjects. Both groups had similar distribution of alleles and genotypes created by the three coding polymorphisms of LEPR gene. No differences in frequencies of genotypes or alleles between cases and controls for any polymorphism individually were found by chi(2) analysis (p=0.444, p=0.507 and p=0.662, respectively). Further, when the haplotypes of three polymorphisms were assessed, no association for any haplotype of three polymorphisms was revealed. In the present study, the three coding polymorphisms in LEPR gene were firstly investigated in a population of northern Chinese. It was suggested that the three coding polymorphisms in LEPR gene were unlikely to have major effects on susceptibility to obesity in northern Chinese. (c) 2007 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
关键词	LEPR gene Obesity Case control study Haplotype
学科领域	遗传学
	2007-12-01
语种	英语
发表期刊	OBESITY RESEARCH & CLINICAL PRACTICE
ISSN	1871-403X
卷号	1 期号:4 页码:261-266
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000206062000005
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5183
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Z. Yang; L.Wang
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Human & Anim Genet, Grad Sch, Beijing 100101, Peoples R China 2.Tianjin Med Univ, Second Hosp, Tianjin Inst Urol, Tianjin 30021, Peoples R China 3.Beijing Hosp, Natl Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 5.Harbin Med Coll, Sch Publ Hlth, Harbin 150081, Peoples R China
推荐引用方式 GB/T 7714	Qu, Yanchun,Yang, Ze,Jin, Feng,et al. Analysis of the relationship between three coding polymorphisms in LEPR gene and obesity in northern Chinese[J]. OBESITY RESEARCH & CLINICAL PRACTICE,2007,1(4):261-266.
APA	Qu, Yanchun.,Yang, Ze.,Jin, Feng.,Sun, Liang.,Zhang, Chuanfang.,...&L.Wang.(2007).Analysis of the relationship between three coding polymorphisms in LEPR gene and obesity in northern Chinese.OBESITY RESEARCH & CLINICAL PRACTICE,1(4),261-266.
MLA	Qu, Yanchun,et al."Analysis of the relationship between three coding polymorphisms in LEPR gene and obesity in northern Chinese".OBESITY RESEARCH & CLINICAL PRACTICE 1.4(2007):261-266.

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