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Anticipation of pain enhances the nociceptive transmission and functional connectivity within pain network in rats
Wang, Jin-Yan1; Zhang, Han-Ti2; Chang, Jing-Yu3; Woodward, Donald J.3; Baccala, Luiz A.4; Luo, Fei1; J. Y. Wang
2008-08-26
Source PublicationMOLECULAR PAIN
ISSN1744-8069
SubtypeArticle
Volume4Issue:4
AbstractBackground: Expectation is a very potent pain modulator in both humans and animals. There is evidence that pain transmission neurons are modulated by expectation preceding painful stimuli. Nonetheless, few studies have examined the influence of pain expectation on the pain-related neuronal activity and the functional connectivity within the central nociceptive network. Results: This study used a tone-laser conditioning paradigm to establish the pain expectation in rats, and simultaneously recorded the anterior cingulate cortex (ACC), the medial dorsal thalamus (MD), and the primary somatosensory cortex (SI) to investigate the effect of pain expectation on laser-induced neuronal responses. Cross-correlation and partial directed coherence analysis were used to determine the functional interactions within and between the recorded areas during nociceptive transmission. The results showed that under anticipation condition, the neuronal activity to the auditory cue was significantly increased in the ACC area, whereas those to actual noxious stimuli were enhanced in all the recorded areas. Furthermore, neuronal correlations within and between these areas were significantly increased under conditions of expectation compared to those under non-expectation conditions, indicating an enhanced synchronization of neural activity within the pain network. In addition, information flow from the medial (ACC and MD) to the lateral (SI cortex) pain pathway increased, suggesting that the emotion-related neural circuits may modulate the neuronal activity in the somatosensory pathway during nociceptive transmission. Conclusion: These results demonstrate that the nociceptive processing in both medial and lateral pain systems is modulated by the expectation of pain.; Background: Expectation is a very potent pain modulator in both humans and animals. There is evidence that pain transmission neurons are modulated by expectation preceding painful stimuli. Nonetheless, few studies have examined the influence of pain expectation on the pain-related neuronal activity and the functional connectivity within the central nociceptive network.
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000258959700001
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5187
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorJ. Y. Wang
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
3.Neurosci Res Inst N Carolina, Winston Salem, NC USA
4.Univ Sao Paulo, Escola Politecn, BR-05508 Sao Paulo, Brazil
Recommended Citation
GB/T 7714
Wang, Jin-Yan,Zhang, Han-Ti,Chang, Jing-Yu,et al. Anticipation of pain enhances the nociceptive transmission and functional connectivity within pain network in rats[J]. MOLECULAR PAIN,2008,4(4).
APA Wang, Jin-Yan.,Zhang, Han-Ti.,Chang, Jing-Yu.,Woodward, Donald J..,Baccala, Luiz A..,...&J. Y. Wang.(2008).Anticipation of pain enhances the nociceptive transmission and functional connectivity within pain network in rats.MOLECULAR PAIN,4(4).
MLA Wang, Jin-Yan,et al."Anticipation of pain enhances the nociceptive transmission and functional connectivity within pain network in rats".MOLECULAR PAIN 4.4(2008).
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