PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease
B. Wang; F. Jin; Y. Xie; Y. Tang; R. Kan; C. Zheng; Z. Yang; L. Wang
2006
Source PublicationNeuroscience Letters
ISSN0304-3940
Volume409Issue:3Pages:179-181
AbstractAlterations of the NAD(P)H:quinone oxidoreductase (NQO1) activity are associated with Alzheimer's disease (AD). A polymorphism consisting of a single nucleotide (C -> T) change at position 609 of NQO1 influences the NQO1 activity. Therefore the NQO1 C609T polymorphism may confer susceptibility for AD developing. To test the hypothesis, we have performed an association study between the NQO1 gene polymorphism C609T and late-onset Alzheimer's disease (LOAD) in Chinese population. Totally 104 LOAD patients and 128 controls were enrolled in our data set. All subjects were genotyped for NQO1 and Apolipoprotein E (APOE). There were no significant differences in NQO1 genotype or allele frequencies between cases and controls. Likewise, with the stratification of APOE epsilon 4 status, no statistical difference was observed between cases and controls. Our findings suggested that this polymorphism might not represent additional genetic risk factor for LOAD. However, the present study cannot exclude NQO1 as a possible candidate for LOAD. Further study in a larger population and biological functional analysis of NQO1 gene is required to verify the role of NQO1 in LOAD.
Keywordlate-onset Alzheimer's disease APOE epsilon 4 NQO1 case-control study Chinese
Subject Area医学心理学
Language英语
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5199
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorL. Wang
Recommended Citation
GB/T 7714
B. Wang,F. Jin,Y. Xie,et al. Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease[J]. Neuroscience Letters,2006,409(3):179-181.
APA B. Wang.,F. Jin.,Y. Xie.,Y. Tang.,R. Kan.,...&L. Wang.(2006).Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease.Neuroscience Letters,409(3),179-181.
MLA B. Wang,et al."Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease".Neuroscience Letters 409.3(2006):179-181.
Files in This Item:
File Name/Size DocType Version Access License
Wang-2006-Associatio(103KB) 限制开放--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[B. Wang]'s Articles
[F. Jin]'s Articles
[Y. Xie]'s Articles
Baidu academic
Similar articles in Baidu academic
[B. Wang]'s Articles
[F. Jin]'s Articles
[Y. Xie]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[B. Wang]'s Articles
[F. Jin]'s Articles
[Y. Xie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Wang-2006-Association analysis.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.