Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease
B. Wang; F. Jin; Y. Xie; Y. Tang; R. Kan; C. Zheng; Z. Yang; L. Wang
2006
发表期刊Neuroscience Letters
ISSN0304-3940
卷号409期号:3页码:179-181
摘要Alterations of the NAD(P)H:quinone oxidoreductase (NQO1) activity are associated with Alzheimer's disease (AD). A polymorphism consisting of a single nucleotide (C -> T) change at position 609 of NQO1 influences the NQO1 activity. Therefore the NQO1 C609T polymorphism may confer susceptibility for AD developing. To test the hypothesis, we have performed an association study between the NQO1 gene polymorphism C609T and late-onset Alzheimer's disease (LOAD) in Chinese population. Totally 104 LOAD patients and 128 controls were enrolled in our data set. All subjects were genotyped for NQO1 and Apolipoprotein E (APOE). There were no significant differences in NQO1 genotype or allele frequencies between cases and controls. Likewise, with the stratification of APOE epsilon 4 status, no statistical difference was observed between cases and controls. Our findings suggested that this polymorphism might not represent additional genetic risk factor for LOAD. However, the present study cannot exclude NQO1 as a possible candidate for LOAD. Further study in a larger population and biological functional analysis of NQO1 gene is required to verify the role of NQO1 in LOAD.
关键词late-onset Alzheimer's disease APOE epsilon 4 NQO1 case-control study Chinese
学科领域医学心理学
语种英语
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5199
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者L. Wang
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B. Wang,F. Jin,Y. Xie,et al. Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease[J]. Neuroscience Letters,2006,409(3):179-181.
APA B. Wang.,F. Jin.,Y. Xie.,Y. Tang.,R. Kan.,...&L. Wang.(2006).Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease.Neuroscience Letters,409(3),179-181.
MLA B. Wang,et al."Association analysis of NAD(P)H:quinone oxidoreductase gene 609 C/T polymorphism with Alzheimer's disease".Neuroscience Letters 409.3(2006):179-181.
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