Cerebral response to patient's own name in the vegetative and minimally conscious states
Di, H. B.; Yu, S. M.; Weng, X. C.; Laureys, S.; Yu, D.; Li, J. Q.; Qin, P. M.; Zhu, Y. H.; Zhang, S. Z.; Chen, Y. Z.; Y. Z. Chen
2007-03-20
发表期刊NEUROLOGY
ISSN0028-3878
文章类型Article
卷号68期号:12页码:895-899
摘要Background: A challenge in the management of severely brain- damaged patients with altered states of consciousness is the differential diagnosis between the vegetative state ( VS) and the minimally conscious state ( MCS), especially for the gray zone separating these clinical entities. Objective: To evaluate the differences in brain activation in response to presentation of the patient's own name spoken by a familiar voice ( SON- FV) in patients with VS and MCS. Methods: By using fMRI, we prospectively studied residual cerebral activation to SON- FV in seven patients with VS and four with MCS. Behavioral evaluation was performed by means of standardized testing up to 3 months post- fMRI. Results: Two patients with VS failed to show any significant cerebral activation. Three patients with VS showed SON- FV induced activation within the primary auditory cortex. Finally, two patients with VS and all four patients with MCS not only showed activation in primary auditory cortex but also in hierarchically higher order associative temporal areas. These two patients with VS showing the most widespread activation subsequently showed clinical improvement to MCS observed 3 months after their fMRI scan. Conclusion: The cerebral responses to patient's own name spoken by a familiar voice as measured by fMRI might be a useful tool to preclinically distinguish minimally conscious state - like cognitive processing in some patients behaviorally classified as vegetative.; Background: A challenge in the management of severely brain- damaged patients with altered states of consciousness is the differential diagnosis between the vegetative state ( VS) and the minimally conscious state ( MCS), especially for the gray zone separating these clinical entities. Objective: To evaluate the differences in brain activation in response to presentation of the patient's own name spoken by a familiar voice ( SON- FV) in patients with VS and MCS. Methods: By using fMRI, we prospectively studied residual cerebral activation to SON- FV in seven patients with VS and four with MCS. Behavioral evaluation was performed by means of standardized testing up to 3 months post- fMRI. Results: Two patients with VS failed to show any significant cerebral activation. Three patients with VS showed SON- FV induced activation within the primary auditory cortex. Finally, two patients with VS and all four patients with MCS not only showed activation in primary auditory cortex but also in hierarchically higher order associative temporal areas. These two patients with VS showing the most widespread activation subsequently showed clinical improvement to MCS observed 3 months after their fMRI scan. Conclusion: The cerebral responses to patient's own name spoken by a familiar voice as measured by fMRI might be a useful tool to preclinically distinguish minimally conscious state - like cognitive processing in some patients behaviorally classified as vegetative.
关键词neural mechanisms brain-function scale fmri coma pet recovery
学科领域认知神经科学 ; 医学心理学
收录类别SCI
语种英语
WOS记录号WOS:000245034400005
引用统计
被引频次:178[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5241
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Y. Z. Chen
作者单位1.Zhejiang Univ, Sch Med, Hangzhou 310006, Peoples R China
2.Hangzhou Teachers Coll, Hangzhou, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing, Peoples R China
4.Wujing Hosp Hangzhou City, Rehabil Ctr Brain Damage, Hangzhou, Peoples R China
5.Univ Liege, Cyclotron Res Ctr, Liege, Belgium
6.Univ Liege, Dept Neurol, Liege, Belgium
7.Sart Tilman Univ, Med Ctr, Dept Neurol, Liege, Belgium
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GB/T 7714
Di, H. B.,Yu, S. M.,Weng, X. C.,et al. Cerebral response to patient's own name in the vegetative and minimally conscious states[J]. NEUROLOGY,2007,68(12):895-899.
APA Di, H. B..,Yu, S. M..,Weng, X. C..,Laureys, S..,Yu, D..,...&Y. Z. Chen.(2007).Cerebral response to patient's own name in the vegetative and minimally conscious states.NEUROLOGY,68(12),895-899.
MLA Di, H. B.,et al."Cerebral response to patient's own name in the vegetative and minimally conscious states".NEUROLOGY 68.12(2007):895-899.
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