PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain
Guo, Jian-You1; Li, Chang-Yu2; Ruan, Ye-Ping2; Sun, Meng1; Qi, Xiao-Li1; Zhao, Bao-Sheng3; Luo, Fei1; J. Y. Guo; F. Luo
2009-06-10
Source PublicationEUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
SubtypeArticle
Volume612Issue:1-3Pages:54-60
AbstractRecent clinical trails reported that adjunctive cyclooxygenase (COX)-2 inhibition with celecoxib is beneficial in treating depression. However, another clinical study showed celecoxib did not have inhibitory effect of COX-2 in human brain when given at a therapeutic dose. Therefore, whether celecoxib is exerting its influence through COX inhibition or by some other mechanism remains unclear. The present study further investigated the effect of celecoxib on COX-2 expression, prostaglandin E2 (PGE2, a major COX-2-mediated inflammatory mediator) concentration and the depressive-like behaviors in rats. Celecoxib was administrated by oral gavage to naive rats (16 mg/kg) or stressed rats (2, 8, 16 mg/kg, respectively) for 21 days, or to stressed rats for a single dose (16 mg/kg). The results showed that 21 days chronic unpredictable stress induced depressive-like behaviors and increased the COX-2 expression and PGE2 concentration in rat brain. Chronic treatments with celecoxib alleviated the depressive-like behavior and reversed the levels of COX-2 expression and PGE2 concentration in stressed rat in a dose-dependent manner. Celecoxib also improved the emotional state and decreased COX-2 expression and PGE2 concentration in naive rats. In addition, a single dose of celecoxib treatment reversed COX-2 expression and PGE2 concentration, but didn't alter the depressive-like behavior in stressed rat. These results suggest that COX-2 enzyme might play a key role in pathophysiology of depression. Furthermore, these data indicate that chronic celecoxib treatment reverse chronic unpredictable stress-induced depressive-like behavior might via reducing COX-2 enzyme in brain, and the selective COX-2 inhibitors could be developed as potential remedies for the management of depression.; Recent clinical trails reported that adjunctive cyclooxygenase (COX)-2 inhibition with celecoxib is beneficial in treating depression. However, another clinical study showed celecoxib did not have inhibitory effect of COX-2 in human brain when given at a therapeutic dose. Therefore, whether celecoxib is exerting its influence through COX inhibition or by some other mechanism remains unclear. The present study further investigated the effect of celecoxib on COX-2 expression, prostaglandin E(2) (PGE(2), a major COX-2-mediated inflammatory mediator) concentration and the depressive-like behaviors in rats. Celecoxib was administrated by oral gavage to naive rats (16 mg/kg) or stressed rats (2, 8, 16 mg/kg, respectively) for 21 days, or to stressed rats for a single dose (16 mg/kg). The results showed that 21 days chronic unpredictable stress induced depressive-like behaviors and increased the COX-2 expression and PGE(2) concentration in rat brain. Chronic treatments with celecoxib alleviated the depressive-like behavior and reversed the levels of COX-2 expression and PGE2 concentration in stressed rat in a dose-dependent manner. Celecoxib also improved the emotional state and decreased COX-2 expression and PGE(2) concentration in naive rats. In addition, a single dose of celecoxib treatment reversed COX-2 expression and PGE(2) concentration. but didn't alter the depressive-like behavior in stressed rat. These results suggest that COX-2 enzyme might play a key role in pathophysiology of depression. Furthermore, these data indicate that chronic celecoxib treatment reverse chronic unpredictable stress-induced depressive-like behavior might via reducing COX-2 enzyme in brain, and the selective COX-2 inhibitors could be developed as potential remedies for the management of depression. (C) 2009 Elsevier B.V. All rights reserved.
KeywordCelecoxib Depressive-like behavior Chronic unpredictable stress Cyclooxygenase-2 Prostaglandin E2
Subject Area健康心理学 ; 临床与咨询心理学
Indexed BySCI
Language英语
WOS IDWOS:000267150900009
Citation statistics
Cited Times:98[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5255
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorJ. Y. Guo; F. Luo
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Zhejiang Chinese Med Univ, Hangzhou 310053, Peoples R China
3.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Guo, Jian-You,Li, Chang-Yu,Ruan, Ye-Ping,et al. Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2009,612(1-3):54-60.
APA Guo, Jian-You.,Li, Chang-Yu.,Ruan, Ye-Ping.,Sun, Meng.,Qi, Xiao-Li.,...&F. Luo.(2009).Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain.EUROPEAN JOURNAL OF PHARMACOLOGY,612(1-3),54-60.
MLA Guo, Jian-You,et al."Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain".EUROPEAN JOURNAL OF PHARMACOLOGY 612.1-3(2009):54-60.
Files in This Item:
File Name/Size DocType Version Access License
Guo-2009-Chronic tre(904KB) 限制开放--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo, Jian-You]'s Articles
[Li, Chang-Yu]'s Articles
[Ruan, Ye-Ping]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo, Jian-You]'s Articles
[Li, Chang-Yu]'s Articles
[Ruan, Ye-Ping]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo, Jian-You]'s Articles
[Li, Chang-Yu]'s Articles
[Ruan, Ye-Ping]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Guo-2009-Chronic treatment wi.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.