PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
Common Genetic Variation and the Control of HIV-1 in Humans
Fellay, Jacques1; Ge, Dongliang1; Shianna, Kevin V.1,2; Colombo, Sara3; Ledergerber, Bruno4; Cirulli, Elizabeth T.1; Urban, Thomas J.1; Zhang, Kunlin3,5; Gumbs, Curtis E.1; Smith, Jason P.2; Castagna, Antonella6; Cozzi-Lepri, Alessandro7; De Luca, Andrea8; Easterbrook, Philippa9,10,11; Guenthard, Huldrych F.4; Mallal, Simon12,13; Mussini, Cristina14; Dalmau, Judith15,16; Martinez-Picado, Javier15,16,17; Miro, Jose M.18; Obel, Niels19; Wolinsky, Steven M.20; Martinson, Jeremy J.21; Detels, Roger22; Margolick, Joseph B.23; Jacobson, Lisa P.24; Descombes, Patrick25; Antonarakis, Stylianos E.26; Beckmann, Jacques S.27,28; O'Brien, Stephen J.29; Letvin, Norman L.30; McMichael, Andrew J.31; Haynes, Barton F.32; Carrington, Mary33,34; Feng, Sheng1; Telenti, Amalio3; Goldstein, David B.1; NIAID Ctr HIV AIDS Vaccine Immunol; D. B. Goldstein
2009-12-01
Source PublicationPLOS GENETICS
ISSN1553-7390
SubtypeArticle
Volume5Issue:12
AbstractTo extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.; To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
Keywordgenome-wide association hla-c host genetics infection aids progression disease polymorphism resistance hcp5
Subject Area遗传学
Indexed BySCI
Language英语
WOS IDWOS:000273469700041
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5259
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorD. B. Goldstein
Affiliation1.Duke Univ, Ctr Human Genome Variat, Duke Inst Genome Sci & Policy, Durham, NC 27706 USA
2.Duke Univ, Genom Anal Facil, Duke Inst Genome Sci & Policy, Durham, NC USA
3.Univ Lausanne, Inst Microbiol, Lausanne, Switzerland
4.Univ Zurich, Univ Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland
5.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China
6.Vita Salute San Raffaele Univ & Diagnost & Ric Sa, Clin Infect Dis, Milan, Italy
7.UCL, Res Dept Infect & Populat Hlth, London, England
8.Univ Cattolica Sacro Cuore, Inst Clin Infect Dis, I-00168 Rome, Italy
9.Kings Coll London, Acad Dept HIV GUM, Weston Educ Ctr, Guys Hosp, London WC2R 2LS, England
10.Kings Coll London, Acad Dept HIV GUM, Weston Educ Ctr, Kings Hosp, London WC2R 2LS, England
11.Kings Coll London, Acad Dept HIV GUM, St Thomas Hosp, Weston Educ Ctr, London, England
12.Royal Perth Hosp, Ctr Clin Immunol & Biomed Stat, Inst Immunol & Infect Dis, Perth, WA, Australia
13.Murdoch Univ, Perth, WA, Australia
14.Azienda Osped Univ, Infect Dis Clin, Modena, Italy
15.IrsiCaixa Fdn, Badalona, Spain
16.Hosp Badalona Germans Trias & Pujol, Badalona, Spain
17.ICREA, Barcelona, Spain
18.Univ Barcelona, Hosp Clin, IDIBAPS, Barcelona, Spain
19.Univ Copenhagen Hosp, Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark
20.Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA
21.Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA
22.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
23.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA
24.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
25.Univ Geneva, Natl Ctr Competence Res Frontiers Genet, Geneva, Switzerland
26.Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland
27.Univ Lausanne, Dept Med Genet, Lausanne, Switzerland
28.CHU Vaudois, Serv Med Genet, CH-1011 Lausanne, Switzerland
29.NCI, Lab Genom Divers, Frederick, MD 21701 USA
30.Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Viral Pathogenesis, Boston, MA 02215 USA
31.John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DU, England
32.Duke Univ, Duke Human Vaccine Inst, Durham, NC USA
33.NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick Inc, Frederick, MD 21701 USA
34.Massachusetts Gen Hosp, Ragon Inst, MIT& Harvard, Boston, MA 02114 USA
Recommended Citation
GB/T 7714
Fellay, Jacques,Ge, Dongliang,Shianna, Kevin V.,et al. Common Genetic Variation and the Control of HIV-1 in Humans[J]. PLOS GENETICS,2009,5(12).
APA Fellay, Jacques.,Ge, Dongliang.,Shianna, Kevin V..,Colombo, Sara.,Ledergerber, Bruno.,...&D. B. Goldstein.(2009).Common Genetic Variation and the Control of HIV-1 in Humans.PLOS GENETICS,5(12).
MLA Fellay, Jacques,et al."Common Genetic Variation and the Control of HIV-1 in Humans".PLOS GENETICS 5.12(2009).
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