Common Genetic Variation and the Control of HIV-1 in Humans

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Common Genetic Variation and the Control of HIV-1 in Humans
	Fellay, Jacques 1; Ge, Dongliang 1; Shianna, Kevin V.1,2; Colombo, Sara 3; Ledergerber, Bruno 4; Cirulli, Elizabeth T.1; Urban, Thomas J.1; Zhang, Kunlin3,5 ; Gumbs, Curtis E.1; Smith, Jason P.2; Castagna, Antonella 6; Cozzi-Lepri, Alessandro 7; De Luca, Andrea 8; Easterbrook, Philippa 9,10,11; Guenthard, Huldrych F.4; Mallal, Simon 12,13; Mussini, Cristina 14; Dalmau, Judith 15,16; Martinez-Picado, Javier 15,16,17; Miro, Jose M.18; Obel, Niels 19; Wolinsky, Steven M.20; Martinson, Jeremy J.21; Detels, Roger 22; Margolick, Joseph B.23; Jacobson, Lisa P.24; Descombes, Patrick 25; Antonarakis, Stylianos E.26; Beckmann, Jacques S.27,28; O'Brien, Stephen J.29; Letvin, Norman L.30; McMichael, Andrew J.31; Haynes, Barton F.32; Carrington, Mary 33,34; Feng, Sheng 1; Telenti, Amalio 3; Goldstein, David B.1; NIAID Ctr HIV AIDS Vaccine Immunol ; D. B. Goldstein
摘要	To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.; To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
关键词	genome-wide association hla-c host genetics infection aids progression disease polymorphism resistance hcp5
学科领域	遗传学
	2009-12-01
语种	英语
发表期刊	PLOS GENETICS
ISSN	1553-7390
卷号	5 期号:12
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000273469700041
引用统计	被引频次：324[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5259
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	D. B. Goldstein
作者单位	1.Duke Univ, Ctr Human Genome Variat, Duke Inst Genome Sci & Policy, Durham, NC 27706 USA 2.Duke Univ, Genom Anal Facil, Duke Inst Genome Sci & Policy, Durham, NC USA 3.Univ Lausanne, Inst Microbiol, Lausanne, Switzerland 4.Univ Zurich, Univ Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland 5.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China 6.Vita Salute San Raffaele Univ & Diagnost & Ric Sa, Clin Infect Dis, Milan, Italy 7.UCL, Res Dept Infect & Populat Hlth, London, England 8.Univ Cattolica Sacro Cuore, Inst Clin Infect Dis, I-00168 Rome, Italy 9.Kings Coll London, Acad Dept HIV GUM, Weston Educ Ctr, Guys Hosp, London WC2R 2LS, England 10.Kings Coll London, Acad Dept HIV GUM, Weston Educ Ctr, Kings Hosp, London WC2R 2LS, England 11.Kings Coll London, Acad Dept HIV GUM, St Thomas Hosp, Weston Educ Ctr, London, England 12.Royal Perth Hosp, Ctr Clin Immunol & Biomed Stat, Inst Immunol & Infect Dis, Perth, WA, Australia 13.Murdoch Univ, Perth, WA, Australia 14.Azienda Osped Univ, Infect Dis Clin, Modena, Italy 15.IrsiCaixa Fdn, Badalona, Spain 16.Hosp Badalona Germans Trias & Pujol, Badalona, Spain 17.ICREA, Barcelona, Spain 18.Univ Barcelona, Hosp Clin, IDIBAPS, Barcelona, Spain 19.Univ Copenhagen Hosp, Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark 20.Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA 21.Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA 22.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA 23.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA 24.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA 25.Univ Geneva, Natl Ctr Competence Res Frontiers Genet, Geneva, Switzerland 26.Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland 27.Univ Lausanne, Dept Med Genet, Lausanne, Switzerland 28.CHU Vaudois, Serv Med Genet, CH-1011 Lausanne, Switzerland 29.NCI, Lab Genom Divers, Frederick, MD 21701 USA 30.Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Viral Pathogenesis, Boston, MA 02215 USA 31.John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DU, England 32.Duke Univ, Duke Human Vaccine Inst, Durham, NC USA 33.NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick Inc, Frederick, MD 21701 USA 34.Massachusetts Gen Hosp, Ragon Inst, MIT& Harvard, Boston, MA 02114 USA
推荐引用方式 GB/T 7714	Fellay, Jacques,Ge, Dongliang,Shianna, Kevin V.,et al. Common Genetic Variation and the Control of HIV-1 in Humans[J]. PLOS GENETICS,2009,5(12).
APA	Fellay, Jacques.,Ge, Dongliang.,Shianna, Kevin V..,Colombo, Sara.,Ledergerber, Bruno.,...&D. B. Goldstein.(2009).Common Genetic Variation and the Control of HIV-1 in Humans.PLOS GENETICS,5(12).
MLA	Fellay, Jacques,et al."Common Genetic Variation and the Control of HIV-1 in Humans".PLOS GENETICS 5.12(2009).

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