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Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription
Wang, Yan1,2,3,4; Zheng, Fei1,2; Zhou, Xianju1,2; Sun, Zhongsheng3; Wang, Hongbing1,2; Z. Sun; H.Wang
2009-08-21
Source PublicationNEUROSCIENCE LETTERS
ISSN0304-3940
SubtypeArticle
Volume460Issue:1Pages:36-40
AbstractThe expression of Arc is tightly coupled to synaptic activities. Recent studies suggested the functional relevance of Arc translation in group I metabotropic glutamate receptor (mGluR)-mediated long-term depression. The present study investigated the transcription-dependent changes of Arc in response to the activation of group I mGluR by (RS)-3,5-dihydroxyphenylglycine (DHPG) in cultured cortical neurons. The increase in Arc mRNA did not require de nova protein synthesis, indicating that Arc is an immediate early gene upon DHPG stimulation. We further examined the major pathways involved in group I mGluR signaling, and found that DHPG-induced Arc up-regulation depended on CaMK, PLC, and ERK1/2 activity. Moreover, the activity of NMDA receptors, but not L-type voltage gated calcium channels (L-VGCC), was required for Arc transcription. Interestingly, blocking CaMK, PLC, and NMDAR, but not L-VGCC, suppressed DHPG-stimulated ERK1/2 activation. These data suggest the central role of ERK1/2 in group I mGluR-mediated Arc transcription.; The expression of Arc is tightly coupled to synaptic activities. Recent studies suggested the functional relevance of Arc translation in group I metabotropic glutamate receptor (mGluR)-mediated long-term depression. The present study investigated the transcription-dependent changes of Arc in response to the activation of group I mGluR by (RS)-3,5-dihydroxyphenylglycine (DHPG) in cultured cortical neurons. The increase in Arc mRNA did not require de nova protein synthesis, indicating that Arc is an immediate early gene upon DHPG stimulation. We further examined the major pathways involved in group I mGluR signaling, and found that DHPG-induced Arc up-regulation depended on CaMK, PLC, and ERK1/2 activity. Moreover, the activity of NMDA receptors, but not L-type voltage gated calcium channels (L-VGCC), was required for Arc transcription. Interestingly, blocking CaMK, PLC, and NMDAR, but not L-VGCC, suppressed DHPG-stimulated ERK1/2 activation. These data suggest the central role of ERK1/2 in group I mGluR-mediated Arc transcription. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
KeywordArc NMDA receptor L-Type voltage-gated calcium channel Group1 metabotropic glutamate receptors Transcription ERK1/2
Subject Area遗传学
Indexed BySCI
Language英语
WOS IDWOS:000267633400008
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5275
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorZ. Sun; H.Wang
Affiliation1.Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA
2.Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA
3.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yan,Zheng, Fei,Zhou, Xianju,et al. Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription[J]. NEUROSCIENCE LETTERS,2009,460(1):36-40.
APA Wang, Yan.,Zheng, Fei.,Zhou, Xianju.,Sun, Zhongsheng.,Wang, Hongbing.,...&H.Wang.(2009).Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription.NEUROSCIENCE LETTERS,460(1),36-40.
MLA Wang, Yan,et al."Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription".NEUROSCIENCE LETTERS 460.1(2009):36-40.
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