Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription

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	Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription
	Wang, Yan 1,2,3,4; Zheng, Fei 1,2; Zhou, Xianju 1,2; Sun, Zhongsheng3 ; Wang, Hongbing 1,2; Z. Sun ; H.Wang
摘要	The expression of Arc is tightly coupled to synaptic activities. Recent studies suggested the functional relevance of Arc translation in group I metabotropic glutamate receptor (mGluR)-mediated long-term depression. The present study investigated the transcription-dependent changes of Arc in response to the activation of group I mGluR by (RS)-3,5-dihydroxyphenylglycine (DHPG) in cultured cortical neurons. The increase in Arc mRNA did not require de nova protein synthesis, indicating that Arc is an immediate early gene upon DHPG stimulation. We further examined the major pathways involved in group I mGluR signaling, and found that DHPG-induced Arc up-regulation depended on CaMK, PLC, and ERK1/2 activity. Moreover, the activity of NMDA receptors, but not L-type voltage gated calcium channels (L-VGCC), was required for Arc transcription. Interestingly, blocking CaMK, PLC, and NMDAR, but not L-VGCC, suppressed DHPG-stimulated ERK1/2 activation. These data suggest the central role of ERK1/2 in group I mGluR-mediated Arc transcription.; The expression of Arc is tightly coupled to synaptic activities. Recent studies suggested the functional relevance of Arc translation in group I metabotropic glutamate receptor (mGluR)-mediated long-term depression. The present study investigated the transcription-dependent changes of Arc in response to the activation of group I mGluR by (RS)-3,5-dihydroxyphenylglycine (DHPG) in cultured cortical neurons. The increase in Arc mRNA did not require de nova protein synthesis, indicating that Arc is an immediate early gene upon DHPG stimulation. We further examined the major pathways involved in group I mGluR signaling, and found that DHPG-induced Arc up-regulation depended on CaMK, PLC, and ERK1/2 activity. Moreover, the activity of NMDA receptors, but not L-type voltage gated calcium channels (L-VGCC), was required for Arc transcription. Interestingly, blocking CaMK, PLC, and NMDAR, but not L-VGCC, suppressed DHPG-stimulated ERK1/2 activation. These data suggest the central role of ERK1/2 in group I mGluR-mediated Arc transcription. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
关键词	Arc NMDA receptor L-Type voltage-gated calcium channel Group1 metabotropic glutamate receptors Transcription ERK1/2
学科领域	遗传学
	2009-08-21
语种	英语
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	460 期号:1 页码:36-40
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000267633400008
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5275
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Z. Sun; H.Wang
作者单位	1.Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA 2.Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA 3.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
第一作者单位	健康与遗传心理学研究室
推荐引用方式 GB/T 7714	Wang, Yan,Zheng, Fei,Zhou, Xianju,et al. Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription[J]. NEUROSCIENCE LETTERS,2009,460(1):36-40.
APA	Wang, Yan.,Zheng, Fei.,Zhou, Xianju.,Sun, Zhongsheng.,Wang, Hongbing.,...&H.Wang.(2009).Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription.NEUROSCIENCE LETTERS,460(1),36-40.
MLA	Wang, Yan,et al."Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription".NEUROSCIENCE LETTERS 460.1(2009):36-40.

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