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Cortical language activation in aphasia: a functional MRI study
Xu, XJ; Zhang, MM; Shang, DS; Wang, QD; Luo, BY; Weng, XC; M. M. Zhang
2004-07-01
Source PublicationCHINESE MEDICAL JOURNAL
ISSN0366-6999
SubtypeArticle
Volume117Issue:7Pages:1011-1016
AbstractBackground Functional neuroimaging has been used in neurolinguistic research on normal subjects and on patients with brain damage. This study was designed to investigate the differences of the neural basis underlying language processing between normal subjects and aphasics. Methods Functional magnetic resonance imaging (fMRI) was used to map the language network in 6 normal subjects and 3 patients with aphasia who were in the stage of recovery from acute stroke. The participants performed a word generation task during multi-slice functional scanning for the measurement of signal change associated with regional neural activity induced by the task. Results In normal subjects, a distributed language network was activated. Activations were present in the frontal, temporal, parietal and occipital regions. In the patient group, however, no activation was detected in the left inferior frontal gyrus whether the patient had a lesion in the left frontal lobe or not. Two patients showed activations in some right hemisphere regions where no activation appeared in normal subjects. Conclusions fMRI with word generation task is feasible for evaluating language function in aphasic patients. Remote effect of focal lesion and functional redistribution or reorganisation can be found in aphasic patients.; Background Functional neuroimaging has been used in neurolinguistic research on normal subjects and on patients with brain damage. This study was designed to investigate the differences of the neural basis underlying language processing between normal subjects and aphasics.
Keywordaphasia magnetic resonance imaging functional language human brain mapping
Subject Area认知神经科学 ; 心理语言学
Indexed BySCI
Language英语
WOS IDWOS:000223074200010
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5277
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorM. M. Zhang
Affiliation1.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Neurol, Hangzhou 310003, Peoples R China
2.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Radiol, Hangzhou 310003, Peoples R China
3.Acad Sinica, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Xu, XJ,Zhang, MM,Shang, DS,et al. Cortical language activation in aphasia: a functional MRI study[J]. CHINESE MEDICAL JOURNAL,2004,117(7):1011-1016.
APA Xu, XJ.,Zhang, MM.,Shang, DS.,Wang, QD.,Luo, BY.,...&M. M. Zhang.(2004).Cortical language activation in aphasia: a functional MRI study.CHINESE MEDICAL JOURNAL,117(7),1011-1016.
MLA Xu, XJ,et al."Cortical language activation in aphasia: a functional MRI study".CHINESE MEDICAL JOURNAL 117.7(2004):1011-1016.
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