Corticofugal influences on thalamic neurons during nociceptive transmission in awake rats
Wang, Jin-Yan; Chang, Jing-Yu; Woodward, Donald J.; Baccala, Luiz A.; Han, Ji-Sheng; Luo, Fei; F. Luo
2007-05-01
发表期刊SYNAPSE
ISSN0887-4476
文章类型Article
卷号61期号:5页码:335-342
摘要Pain is a multidimensional phenomenon and processed in a neural network. The supraspinal, brain mechanisms are increasingly recognized in playing a major role in the representation and modulation of pain. The aim of the current study is to investigate the functional interactions between cortex and thalamus during nociceptive processing, by observing the pain-related information flow and neuronal correlations within thalamo-cortical pathways. Pain-evoked, single-neuron activity was recorded in awake Sprague-Dawley rats with a Magnet system. Eight-wire microarrays were implanted into four different brain regions, i.e., the primary somatosensory (SI) and anterior cingulate cortex (ACC), as well as ventral posterior (VP) and medial dorsal thalamus (MD). Noxious radiant heat was delivered to the rat hind paws on the side contralateral to the recording regions. A large number of responsive neurons were recorded in the four brain areas. Directed coherence analysis revealed that the amount of information flow was significantly increased from SI cortex to VP thalamus following noxious stimuli, suggesting that SI cortex has descending influence on thalamic neurons during pain processing. Moreover, more correlated neuronal activities indicated by crosscorrelation histograms were found between cortical and thalamic neurons, with cortical neurons firing ahead of thalamic units. On basis of the above findings, we propose that nociceptive responses are modulated by corticothalamic feedback during nociceptive transmission, which may be tight in the lateral pathway, while loose in the medial pathway.; Pain is a multidimensional phenomenon and processed in a neural network. The supraspinal, brain mechanisms are increasingly recognized in playing a major role in the representation and modulation of pain. The aim of the current study is to investigate the functional interactions between cortex and thalamus during nociceptive processing, by observing the pain-related information flow and neuronal correlations within thalamo-cortical pathways. Pain-evoked, single-neuron activity was recorded in awake Sprague-Dawley rats with a Magnet system. Eight-wire microarrays were implanted into four different brain regions, i.e., the primary somatosensory (SI) and anterior cingulate cortex (ACC), as well as ventral posterior (VP) and medial dorsal thalamus (MD). Noxious radiant heat was delivered to the rat hind paws on the side contralateral to the recording regions. A large number of responsive neurons were recorded in the four brain areas. Directed coherence analysis revealed that the amount of information flow was significantly increased from SI cortex to VP thalamus following noxious stimuli, suggesting that SI cortex has descending influence on thalamic neurons during pain processing. Moreover, more correlated neuronal activities indicated by crosscorrelation histograms were found between cortical and thalamic neurons, with cortical neurons firing ahead of thalamic units. On basis of the above findings, we propose that nociceptive responses are modulated by corticothalamic feedback during nociceptive transmission, which may be tight in the lateral pathway, while loose in the medial pathway.
关键词cortex cingulate thalamus nociception crosscorrelation information flow
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000244830400008
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5279
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者F. Luo
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Wake Forest Univ Hlth Sci, Dept Physiol & Pharmacol, Winston Salem, NC USA
3.Neurosci Res Inst N Carolina, Winston Salem, NC USA
4.Univ Sao Paulo, Escola Politecn, Sao Paulo, Brazil
5.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jin-Yan,Chang, Jing-Yu,Woodward, Donald J.,et al. Corticofugal influences on thalamic neurons during nociceptive transmission in awake rats[J]. SYNAPSE,2007,61(5):335-342.
APA Wang, Jin-Yan.,Chang, Jing-Yu.,Woodward, Donald J..,Baccala, Luiz A..,Han, Ji-Sheng.,...&F. Luo.(2007).Corticofugal influences on thalamic neurons during nociceptive transmission in awake rats.SYNAPSE,61(5),335-342.
MLA Wang, Jin-Yan,et al."Corticofugal influences on thalamic neurons during nociceptive transmission in awake rats".SYNAPSE 61.5(2007):335-342.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Wang-2007-Corticofug(273KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Jin-Yan]的文章
[Chang, Jing-Yu]的文章
[Woodward, Donald J.]的文章
百度学术
百度学术中相似的文章
[Wang, Jin-Yan]的文章
[Chang, Jing-Yu]的文章
[Woodward, Donald J.]的文章
必应学术
必应学术中相似的文章
[Wang, Jin-Yan]的文章
[Chang, Jing-Yu]的文章
[Woodward, Donald J.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。