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Corticofugal influences on thalamic neurons during nociceptive transmission in awake rats
Wang, Jin-Yan; Chang, Jing-Yu; Woodward, Donald J.; Baccala, Luiz A.; Han, Ji-Sheng; Luo, Fei; F. Luo
2007-05-01
Source PublicationSYNAPSE
ISSN0887-4476
SubtypeArticle
Volume61Issue:5Pages:335-342
AbstractPain is a multidimensional phenomenon and processed in a neural network. The supraspinal, brain mechanisms are increasingly recognized in playing a major role in the representation and modulation of pain. The aim of the current study is to investigate the functional interactions between cortex and thalamus during nociceptive processing, by observing the pain-related information flow and neuronal correlations within thalamo-cortical pathways. Pain-evoked, single-neuron activity was recorded in awake Sprague-Dawley rats with a Magnet system. Eight-wire microarrays were implanted into four different brain regions, i.e., the primary somatosensory (SI) and anterior cingulate cortex (ACC), as well as ventral posterior (VP) and medial dorsal thalamus (MD). Noxious radiant heat was delivered to the rat hind paws on the side contralateral to the recording regions. A large number of responsive neurons were recorded in the four brain areas. Directed coherence analysis revealed that the amount of information flow was significantly increased from SI cortex to VP thalamus following noxious stimuli, suggesting that SI cortex has descending influence on thalamic neurons during pain processing. Moreover, more correlated neuronal activities indicated by crosscorrelation histograms were found between cortical and thalamic neurons, with cortical neurons firing ahead of thalamic units. On basis of the above findings, we propose that nociceptive responses are modulated by corticothalamic feedback during nociceptive transmission, which may be tight in the lateral pathway, while loose in the medial pathway.; Pain is a multidimensional phenomenon and processed in a neural network. The supraspinal, brain mechanisms are increasingly recognized in playing a major role in the representation and modulation of pain. The aim of the current study is to investigate the functional interactions between cortex and thalamus during nociceptive processing, by observing the pain-related information flow and neuronal correlations within thalamo-cortical pathways. Pain-evoked, single-neuron activity was recorded in awake Sprague-Dawley rats with a Magnet system. Eight-wire microarrays were implanted into four different brain regions, i.e., the primary somatosensory (SI) and anterior cingulate cortex (ACC), as well as ventral posterior (VP) and medial dorsal thalamus (MD). Noxious radiant heat was delivered to the rat hind paws on the side contralateral to the recording regions. A large number of responsive neurons were recorded in the four brain areas. Directed coherence analysis revealed that the amount of information flow was significantly increased from SI cortex to VP thalamus following noxious stimuli, suggesting that SI cortex has descending influence on thalamic neurons during pain processing. Moreover, more correlated neuronal activities indicated by crosscorrelation histograms were found between cortical and thalamic neurons, with cortical neurons firing ahead of thalamic units. On basis of the above findings, we propose that nociceptive responses are modulated by corticothalamic feedback during nociceptive transmission, which may be tight in the lateral pathway, while loose in the medial pathway.
Keywordcortex cingulate thalamus nociception crosscorrelation information flow
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000244830400008
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5279
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorF. Luo
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Wake Forest Univ Hlth Sci, Dept Physiol & Pharmacol, Winston Salem, NC USA
3.Neurosci Res Inst N Carolina, Winston Salem, NC USA
4.Univ Sao Paulo, Escola Politecn, Sao Paulo, Brazil
5.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jin-Yan,Chang, Jing-Yu,Woodward, Donald J.,et al. Corticofugal influences on thalamic neurons during nociceptive transmission in awake rats[J]. SYNAPSE,2007,61(5):335-342.
APA Wang, Jin-Yan.,Chang, Jing-Yu.,Woodward, Donald J..,Baccala, Luiz A..,Han, Ji-Sheng.,...&F. Luo.(2007).Corticofugal influences on thalamic neurons during nociceptive transmission in awake rats.SYNAPSE,61(5),335-342.
MLA Wang, Jin-Yan,et al."Corticofugal influences on thalamic neurons during nociceptive transmission in awake rats".SYNAPSE 61.5(2007):335-342.
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