Corticofugal outputs facilitate acute, but inhibit chronic pain in rats
Wang, Ning2,3; Wang, Jin-Yan1; Luo, Fei1,2,3; J.Y. Wang
2009-03-01
发表期刊PAIN
ISSN0304-3959
文章类型Article
卷号142期号:1-2页码:108-115
摘要It has been widely accepted that the primary somatosensory cortex (SI) plays an essential role in the sensory-discriminative aspect of pain perception. However, it remains unclear whether the SI has a role in the descending modulation of pain. Although there are abundant fibers projecting back from sensory cortex to thalamic nuclei, and the influence of cortical modulation from SI on the thalamic nociceptive relay neurons has been addressed, little is known about how the cortical outputs modulate the nociceptive behaviors resulting from tissue injury or evoked by painful stimulation. The present study was designed to test whether the cortical outputs influenced the nociceptive behaviors using rat models of noxious thermal-induced acute pain, formalin-induced acute and CFA-evoked chronic inflammatory pain. The results showed that intracortical microinjection of GABA(A) agonist muscimol significantly reduced the first and second phase behaviors in formalin tests and elevated the nociceptive thresholds in the thermal stimulus-elicited acute pain, suggesting a facilitatory influence of SI on the acute pain sensation. By contrast, microinjection of GABA(A) antagonist bicuculline remarkably reduced the thermal hyperalgesia of the CFA-inflamed hindpaws, indicating an inhibitory effect of SI output in the chronic pain state. The opposite modulatory effects in acute and chronic pain states suggest that there exists a functional switch for the SI cortex at different stages of pain disease, which is of great significance for the biological adaptation.; It has been widely accepted that the primary somatosensory cortex (SI) plays an essential role in the sensory-discriminative aspect of pain perception. However, it remains unclear whether the SI has a role in the descending modulation of pain. Although there are abundant fibers projecting back from sensory cortex to thalamic nuclei, and the influence of cortical modulation from SI on the thalamic nociceptive relay neurons has been addressed, little is known about how the cortical outputs modulate the nociceptive behaviors resulting from tissue injury or evoked by painful stimulation. The present study was designed to test whether the cortical outputs influenced the nociceptive behaviors using rat models of noxious thermal-induced acute pain, formalin-induced acute and CFA-evoked chronic inflammatory pain. The results showed that intracortical microinjection of GABA(A) agonist muscimol significantly reduced the first and second phase behaviors in formalin tests and elevated the nociceptive thresholds in the thermal stimulus-elicited acute pain, suggesting a facilitatory influence of SI on the acute pain sensation. By contrast, microinjection of GABA(A) antagonist bicuculline remarkably reduced the thermal hyperalgesia of the CFA-inflamed hindpaws, indicating an inhibitory effect of SI output in the chronic pain state. The opposite modulatory effects in acute and chronic pain states suggest that there exists a functional switch for the SI cortex at different stages of pain disease, which is of great significance for the biological adaptation. (C) 2008 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
关键词Nociception Primary somatosensory cortex GABA Descending modulation Formalin Complete Freund's adjuvant
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000264275800019
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5281
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者J.Y. Wang
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
3.Peking Univ, Dept Neurobiol, Beijing 100871, Peoples R China
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GB/T 7714
Wang, Ning,Wang, Jin-Yan,Luo, Fei,et al. Corticofugal outputs facilitate acute, but inhibit chronic pain in rats[J]. PAIN,2009,142(1-2):108-115.
APA Wang, Ning,Wang, Jin-Yan,Luo, Fei,&J.Y. Wang.(2009).Corticofugal outputs facilitate acute, but inhibit chronic pain in rats.PAIN,142(1-2),108-115.
MLA Wang, Ning,et al."Corticofugal outputs facilitate acute, but inhibit chronic pain in rats".PAIN 142.1-2(2009):108-115.
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