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Corticofugal outputs facilitate acute, but inhibit chronic pain in rats
Wang, Ning2,3; Wang, Jin-Yan1; Luo, Fei1,2,3; J.Y. Wang
2009-03-01
Source PublicationPAIN
ISSN0304-3959
SubtypeArticle
Volume142Issue:1-2Pages:108-115
AbstractIt has been widely accepted that the primary somatosensory cortex (SI) plays an essential role in the sensory-discriminative aspect of pain perception. However, it remains unclear whether the SI has a role in the descending modulation of pain. Although there are abundant fibers projecting back from sensory cortex to thalamic nuclei, and the influence of cortical modulation from SI on the thalamic nociceptive relay neurons has been addressed, little is known about how the cortical outputs modulate the nociceptive behaviors resulting from tissue injury or evoked by painful stimulation. The present study was designed to test whether the cortical outputs influenced the nociceptive behaviors using rat models of noxious thermal-induced acute pain, formalin-induced acute and CFA-evoked chronic inflammatory pain. The results showed that intracortical microinjection of GABA(A) agonist muscimol significantly reduced the first and second phase behaviors in formalin tests and elevated the nociceptive thresholds in the thermal stimulus-elicited acute pain, suggesting a facilitatory influence of SI on the acute pain sensation. By contrast, microinjection of GABA(A) antagonist bicuculline remarkably reduced the thermal hyperalgesia of the CFA-inflamed hindpaws, indicating an inhibitory effect of SI output in the chronic pain state. The opposite modulatory effects in acute and chronic pain states suggest that there exists a functional switch for the SI cortex at different stages of pain disease, which is of great significance for the biological adaptation.; It has been widely accepted that the primary somatosensory cortex (SI) plays an essential role in the sensory-discriminative aspect of pain perception. However, it remains unclear whether the SI has a role in the descending modulation of pain. Although there are abundant fibers projecting back from sensory cortex to thalamic nuclei, and the influence of cortical modulation from SI on the thalamic nociceptive relay neurons has been addressed, little is known about how the cortical outputs modulate the nociceptive behaviors resulting from tissue injury or evoked by painful stimulation. The present study was designed to test whether the cortical outputs influenced the nociceptive behaviors using rat models of noxious thermal-induced acute pain, formalin-induced acute and CFA-evoked chronic inflammatory pain. The results showed that intracortical microinjection of GABA(A) agonist muscimol significantly reduced the first and second phase behaviors in formalin tests and elevated the nociceptive thresholds in the thermal stimulus-elicited acute pain, suggesting a facilitatory influence of SI on the acute pain sensation. By contrast, microinjection of GABA(A) antagonist bicuculline remarkably reduced the thermal hyperalgesia of the CFA-inflamed hindpaws, indicating an inhibitory effect of SI output in the chronic pain state. The opposite modulatory effects in acute and chronic pain states suggest that there exists a functional switch for the SI cortex at different stages of pain disease, which is of great significance for the biological adaptation. (C) 2008 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
KeywordNociception Primary somatosensory cortex GABA Descending modulation Formalin Complete Freund's adjuvant
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000264275800019
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5281
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorJ.Y. Wang
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
3.Peking Univ, Dept Neurobiol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wang, Ning,Wang, Jin-Yan,Luo, Fei,et al. Corticofugal outputs facilitate acute, but inhibit chronic pain in rats[J]. PAIN,2009,142(1-2):108-115.
APA Wang, Ning,Wang, Jin-Yan,Luo, Fei,&J.Y. Wang.(2009).Corticofugal outputs facilitate acute, but inhibit chronic pain in rats.PAIN,142(1-2),108-115.
MLA Wang, Ning,et al."Corticofugal outputs facilitate acute, but inhibit chronic pain in rats".PAIN 142.1-2(2009):108-115.
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