Depressive Disorders: Focally Altered Cerebral Perfusion Measured with Arterial Spin-labeling MR Imaging
Lui, Su1; Parkes, Laura M.3; Huang, Xiaoqi1,2; Zou, Ke1,2; Chan, Raymond C. K.5,6; Yang, Hong1; Zou, Ling1; Li, Dongming1; Tang, Hehan1; Zhang, Tijiang1; Li, Xiuli1; Wei, Yi1; Chen, Long1; Sun, Xueli2; Kemp, Graham J.; Gong, Qi-Yong1,3,4; Q. Y. Gong
2009-05-01
发表期刊RADIOLOGY
ISSN0033-8419
文章类型Article
卷号251期号:2页码:476-484
摘要Purpose: To assess focal cerebral perfusion in patients with refractory depressive disorder (RDD), patients with nonrefractory depressive disorder (NDD), and healthy control subjects by using arterial spin-labeling (ASL) magnetic resonance (MR) imaging. Materials and Methods: This study was approved by the local ethical committee, and written informed consent was obtained from all participants. Twenty-four patients with RDD, 37 patients with NDD, and 42 healthy control subjects were included. From February 2006 to July 2007, all participants were imaged with a 3-T MR system. ASL and echo-planar images were subtracted and averaged to give perfusion-weighted images. Voxel-based analysis was performed. Region-of-interest analysis was applied to the bilateral hippocampi, thalami, and lentiform nuclei. Results: Patients with NDD showed reduced perfusion in the left prefrontal cortex versus control subjects and increased perfusion mainly in the limbic- striatal areas (P < .05). In contrast, patients with RDD had decreased perfusion predominantly in the bilateral frontal and bilateral thalamic regions (P < .05). Compared with patients with RDD, patients with NDD showed higher perfusion mainly in the limbic- striatal areas (P < .05). In region-of-interest analysis, the NDD group showed higher regional cerebral blood flow than both RDD and control groups in the left hippocampus (P < .045), right hippocampus (P < .001), and right lentiform nucleus (P < .049). Conclusion: This study revealed alterations of regional perfusion in the brains of patients with RDD that differed from those in patients with NDD. These results are consistent with the concept that RDD is associated with decreased activity of the bilateral prefrontal areas; and NDD, with decreased activity of left frontal areas in conjunction with overactivity of the bilateral limbic system.; Purpose: To assess focal cerebral perfusion in patients with refractory depressive disorder (RDD), patients with nonrefractory depressive disorder (NDD), and healthy control subjects by using arterial spin-labeling (ASL) magnetic resonance (MR) imaging.
学科领域变态心理学
收录类别SCI
语种英语
WOS记录号WOS:000265643100021
引用统计
被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5305
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Q. Y. Gong
作者单位1.W China Hosp, W China Sch Clin Med, Dept Radiol, Huaxi MR Res Ctr,State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
2.W China Hosp, W China Sch Clin Med, Dept Psychiat, Chengdu 610041, Sichuan, Peoples R China
3.Univ Liverpool, Sch Clin Sci, Magnet Resonance & Image Anal Res Ctr, Liverpool L69 3BX, Merseyside, England
4.Univ Liverpool, Fac Med, Div Med Imaging, Liverpool L69 3BX, Merseyside, England
5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Lui, Su,Parkes, Laura M.,Huang, Xiaoqi,et al. Depressive Disorders: Focally Altered Cerebral Perfusion Measured with Arterial Spin-labeling MR Imaging[J]. RADIOLOGY,2009,251(2):476-484.
APA Lui, Su.,Parkes, Laura M..,Huang, Xiaoqi.,Zou, Ke.,Chan, Raymond C. K..,...&Q. Y. Gong.(2009).Depressive Disorders: Focally Altered Cerebral Perfusion Measured with Arterial Spin-labeling MR Imaging.RADIOLOGY,251(2),476-484.
MLA Lui, Su,et al."Depressive Disorders: Focally Altered Cerebral Perfusion Measured with Arterial Spin-labeling MR Imaging".RADIOLOGY 251.2(2009):476-484.
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