Depressive Disorders: Focally Altered Cerebral Perfusion Measured with Arterial Spin-labeling MR Imaging

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	Depressive Disorders: Focally Altered Cerebral Perfusion Measured with Arterial Spin-labeling MR Imaging
	Lui, Su 1; Parkes, Laura M.3; Huang, Xiaoqi 1,2; Zou, Ke 1,2; Chan, Raymond C. K.5,6 ; Yang, Hong 1; Zou, Ling 1; Li, Dongming 1; Tang, Hehan 1; Zhang, Tijiang 1; Li, Xiuli 1; Wei, Yi 1; Chen, Long 1; Sun, Xueli 2; Kemp, Graham J.; Gong, Qi-Yong 1,3,4; Q. Y. Gong
摘要	Purpose: To assess focal cerebral perfusion in patients with refractory depressive disorder (RDD), patients with nonrefractory depressive disorder (NDD), and healthy control subjects by using arterial spin-labeling (ASL) magnetic resonance (MR) imaging. Materials and Methods: This study was approved by the local ethical committee, and written informed consent was obtained from all participants. Twenty-four patients with RDD, 37 patients with NDD, and 42 healthy control subjects were included. From February 2006 to July 2007, all participants were imaged with a 3-T MR system. ASL and echo-planar images were subtracted and averaged to give perfusion-weighted images. Voxel-based analysis was performed. Region-of-interest analysis was applied to the bilateral hippocampi, thalami, and lentiform nuclei. Results: Patients with NDD showed reduced perfusion in the left prefrontal cortex versus control subjects and increased perfusion mainly in the limbic- striatal areas (P < .05). In contrast, patients with RDD had decreased perfusion predominantly in the bilateral frontal and bilateral thalamic regions (P < .05). Compared with patients with RDD, patients with NDD showed higher perfusion mainly in the limbic- striatal areas (P < .05). In region-of-interest analysis, the NDD group showed higher regional cerebral blood flow than both RDD and control groups in the left hippocampus (P < .045), right hippocampus (P < .001), and right lentiform nucleus (P < .049). Conclusion: This study revealed alterations of regional perfusion in the brains of patients with RDD that differed from those in patients with NDD. These results are consistent with the concept that RDD is associated with decreased activity of the bilateral prefrontal areas; and NDD, with decreased activity of left frontal areas in conjunction with overactivity of the bilateral limbic system.; Purpose: To assess focal cerebral perfusion in patients with refractory depressive disorder (RDD), patients with nonrefractory depressive disorder (NDD), and healthy control subjects by using arterial spin-labeling (ASL) magnetic resonance (MR) imaging.
学科领域	变态心理学
	2009-05-01
语种	英语
发表期刊	RADIOLOGY
ISSN	0033-8419
卷号	251 期号:2 页码:476-484
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000265643100021
引用统计	被引频次：105[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5305
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Q. Y. Gong
作者单位	1.W China Hosp, W China Sch Clin Med, Dept Radiol, Huaxi MR Res Ctr,State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China 2.W China Hosp, W China Sch Clin Med, Dept Psychiat, Chengdu 610041, Sichuan, Peoples R China 3.Univ Liverpool, Sch Clin Sci, Magnet Resonance & Image Anal Res Ctr, Liverpool L69 3BX, Merseyside, England 4.Univ Liverpool, Fac Med, Div Med Imaging, Liverpool L69 3BX, Merseyside, England 5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Lui, Su,Parkes, Laura M.,Huang, Xiaoqi,et al. Depressive Disorders: Focally Altered Cerebral Perfusion Measured with Arterial Spin-labeling MR Imaging[J]. RADIOLOGY,2009,251(2):476-484.
APA	Lui, Su.,Parkes, Laura M..,Huang, Xiaoqi.,Zou, Ke.,Chan, Raymond C. K..,...&Q. Y. Gong.(2009).Depressive Disorders: Focally Altered Cerebral Perfusion Measured with Arterial Spin-labeling MR Imaging.RADIOLOGY,251(2),476-484.
MLA	Lui, Su,et al."Depressive Disorders: Focally Altered Cerebral Perfusion Measured with Arterial Spin-labeling MR Imaging".RADIOLOGY 251.2(2009):476-484.

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