Dissecting medial temporal lobe contributions to item and associative memory formation
Qin, Shaozheng1,2,4; Rijpkema, Mark; Tendolkar, Indira3; Piekema, Carinne; Hermans, Erno J.; Binder, Marek5; Petersson, Karl Magnus; Luo, Jing4; Fernandez, Guillen2; S. Z. Qin
2009-07-01
发表期刊NEUROIMAGE
ISSN1053-8119
文章类型Article
卷号46期号:3页码:874-881
摘要A fundamental and intensively discussed question is whether medial temporal lobe (MTL) processes that lead to non-associative item memories differ in their anatomical substrate from processes underlying associative memory formation. Using event-related functional magnetic resonance imaging, we implemented a novel design to dissociate brain activity related to item and associative memory formation not only by subsequent memory performance and anatomy but also in time, because the two constituents of each pair to be memorized were presented sequentially with an intra-pair delay of several seconds. Furthermore, the design enabled us to reduce potential differences in memory strength between item and associative memory by increasing task difficulty in the item recognition memory test. Confidence ratings for correct item recognition for both constituents did not differ between trials in which only item memory was correct and trials in which item and associative memory were correct. Specific subsequent memory analyses for item and associative memory formation revealed brain activity that appears selectively related to item memory formation in the posterior inferior temporal, posterior parahippocampal, and perirhinal cortices. In contrast, hippocampal and inferior prefrontal activity predicted successful retrieval of newly formed inter-item associations. Our findings therefore suggest that different MTL subregions indeed play distinct roles in the formation of item memory and inter-item associative memory as expected by several dual process models of the MTL memory system.; A fundamental and intensively discussed question is whether medial temporal lobe (MTL) processes that lead to non-associative item memories differ in their anatomical substrate from processes underlying associative memory formation. Using event-related functional magnetic resonance imaging, we implemented a novel design to dissociate brain activity related to item and associative memory formation not only by subsequent memory performance and anatomy but also in time, because the two constituents of each pair to be memorized were presented sequentially with an intra-pair delay of several seconds. Furthermore, the design enabled us to reduce potential differences in memory strength between item and associative memory by increasing task difficulty in the item recognition memory test. Confidence ratings for correct item recognition for both constituents did not differ between trials in which only item memory was correct and trials in which item and associative memory were correct. Specific subsequent memory analyses for item and associative memory formation revealed brain activity that appears selectively related to item memory formation in the posterior inferior temporal, posterior parahippocampal, and perirhinal cortices. In contrast, hippocampal and inferior prefrontal activity predicted successful retrieval of newly formed inter-item associations. Our findings therefore suggest that different MTL subregions indeed play distinct roles in the formation of item memory and inter-item associative memory as expected by several dual process models of the MTL memory system. (C) 2009 Elsevier Inc. All rights reserved.
关键词Episodic memory Hippocampus Parahippocampal cortex Perirhinal cortex Prefrontal cortex
学科领域认知神经科学
收录类别SCI ; SSCI
语种英语
WOS记录号WOS:000265938700034
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5319
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者S. Z. Qin
作者单位1.Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Ctr Cognit Neuroimaging, NL-6500 HB Nijmegen, Netherlands
2.Radboud Univ Nijmegen, Med Ctr, Dept Neurol, NL-6500 HB Nijmegen, Netherlands
3.Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NL-6500 HB Nijmegen, Netherlands
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Jagiellonian Univ, Psychophysiol Unit, Krakow, Poland
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Qin, Shaozheng,Rijpkema, Mark,Tendolkar, Indira,et al. Dissecting medial temporal lobe contributions to item and associative memory formation[J]. NEUROIMAGE,2009,46(3):874-881.
APA Qin, Shaozheng.,Rijpkema, Mark.,Tendolkar, Indira.,Piekema, Carinne.,Hermans, Erno J..,...&S. Z. Qin.(2009).Dissecting medial temporal lobe contributions to item and associative memory formation.NEUROIMAGE,46(3),874-881.
MLA Qin, Shaozheng,et al."Dissecting medial temporal lobe contributions to item and associative memory formation".NEUROIMAGE 46.3(2009):874-881.
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