Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal
Sun, N; Li, Y; Tian, S; Lei, Y; Zheng, J; Yang, J; Sui, N; Xu, L; Pei, G; Wilson, FAW; Ma, Y; Lei, H; Hu, X; X. Hu; H. Lei
2006
发表期刊NEUROSCIENCE
ISSN0306-4522
文章类型Article
卷号138期号:1页码:77-82
摘要The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place preference paradigm, using manganese-enhanced magnetic resonance imaging and traditional electroencephalograph recording techniques in rats. T1-weighted 2D MRI (4.7 T) was used after unilateral injection of MnCl2 (200 nL, 80 mM) into the right orbitofrontal cortex. The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period. Also, we found decreases and increases in gamma-band (20-100 Hz) activity during the opiate administration and withdrawal period, respectively. Our results showed that orbitofrontal cortex activity decreased during morphine administration and then went up progressively over several days during withdrawal. The time course of the recovery of orbitofrontal activity from inhibition during the withdrawal period may be related to the experience of drug craving.; The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place preference paradigm, using manganese-enhanced magnetic resonance imaging and traditional electroencephalograph recording techniques in rats. T1-weighted 2D MRI (4.7 T) was used after unilateral injection of MnCl2 (200 nL, 80 mM) into the right orbitofrontal cortex. The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period. Also, we found decreases and increases in gamma-band (20-100 Hz) activity during the opiate administration and withdrawal period, respectively. Our results showed that orbitofrontal cortex activity decreased during morphine administration and then went up progressively over several days during withdrawal. The time course of the recovery of orbitofrontal activity from inhibition during the withdrawal period may be related to the experience of drug craving. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.
关键词conditioned place preference manganese-enhanced MRI gamma-band EEG drug craving
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000235947400009
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5333
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者X. Hu; H. Lei
作者单位1.Chinese Acad Sci, Kunming Inst Zool, Lab Primate Cognit Neurosci, Kunming 650223, Peoples R China
2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 43007, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Chinese Acad Sci, Grad Sch, Hunan, Peoples R China
5.Nanhua Univ, Med Sch, Hunan 412000, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
7.Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Kunming 650223, Peoples R China
8.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Lab Mol Cell Biol, Shanghai 200031, Peoples R China
9.Univ Arizona, Dept Psychol, Tucson, AZ USA
10.Univ Arizona, Dept Neurol, Tucson, AZ USA
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GB/T 7714
Sun, N,Li, Y,Tian, S,et al. Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal[J]. NEUROSCIENCE,2006,138(1):77-82.
APA Sun, N.,Li, Y.,Tian, S.,Lei, Y.,Zheng, J.,...&H. Lei.(2006).Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal.NEUROSCIENCE,138(1),77-82.
MLA Sun, N,et al."Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal".NEUROSCIENCE 138.1(2006):77-82.
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