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Dynamic neuronal responses in cortical and thalamic areas during different phases of formalin test in rats
Huang, Jin; Chang, Jing-Yu; Woodward, Donald J.; Baccala, Luiz A.; Han, Ji-Sheng; Wang, Jin-Yan; Luo, Fel; F. Luo
2006-07-01
Source PublicationEXPERIMENTAL NEUROLOGY
ISSN0014-4886
SubtypeArticle
Volume200Issue:1Pages:124-134
AbstractAlthough formalin-induced activity in primary afferent fibers and spinal dorsal horn is well described, the forebrain neural basis underlying each phase of behavior in formalin test has not yet been clarified. The present study was designed to investigate the cortical and thalamic neuronal responses and interactions among forebrain areas during different phases after subcutaneous injection of formalin. Formalin-induced neuronal activities were simultaneously recorded from primary somatosensory cortex (SI), anterior cingulate cortex (ACC) and medial dorsal (MD) and ventral posterior (VP) thalamus during different phases (i.e., first phase, interphase, second phase and third recovery phase starting from 70 min after injection) of formalin test, using a multi-channel, single-unit recording technique. Our results showed that, (i) unlike the responses in primary afferent fibers and spinal dorsal horn, many forebrain neurons displayed monophasic excitatory responses in the first hour after formalin injection, except a small portion of neurons which exhibited biphasic responses; (ii) the response patterns of many cortical and thalamic neurons changed from excitatory to inhibitory at the end of the second phase; (iii) the direction of information flow also changed dramatically, i.e., from cortex to thalamus and from the medial to the lateral pathway in the first hour, but reversed in phase 3. These results indicate that the changes of activity pattern in forebrain networks may underlie the emerging and subsiding of central sensitization-induced pain behavior in the second phase of formalin test.; Although formalin-induced activity in primary afferent fibers and spinal dorsal horn is well described, the forebrain neural basis underlying each phase of behavior in formalin test has not yet been clarified. The present study was designed to investigate the cortical and thalamic neuronal responses and interactions among forebrain areas during different phases after subcutaneous injection of formalin. Formalin-induced neuronal activities were simultaneously recorded from primary somatosensory cortex (SI), anterior cingulate cortex (ACC) and medial dorsal (MD) and ventral posterior (VP) thalamus during different phases (i.e., first phase, interphase, second phase and third recovery phase starting from 70 min after injection) of formalin test, using a multi-channel, single-unit recording technique. Our results showed that, (i) unlike the responses in primary afferent fibers and spinal dorsal horn, many forebrain neurons displayed monophasic excitatory responses in the first hour after formalin injection, except a small portion of neurons which exhibited biphasic responses; (ii) the response patterns of many cortical and thalamic neurons changed from excitatory to inhibitory at the end of the second phase; (iii) the direction of information flow also changed dramatically, i.e., from cortex to thalamus and from the medial to the lateral pathway in the first hour, but reversed in phase 3. These results indicate that the changes of activity pattern in forebrain networks may underlie the emerging and subsiding of central sensitization-induced pain behavior in the second phase of formalin test. (c) 2006 Elsevier Inc. All rights reserved.
Keywordformalin primary somatosensory cortex anterior cingulate cortex thalamus nociception
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000239503000014
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5335
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorF. Luo
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Neurosci Res Inst, Beijing, Peoples R China
3.Wake Forest Univ Hlth Sci, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA
4.Univ Sao Paulo, Escola Politecn, Sao Paulo, Brazil
Recommended Citation
GB/T 7714
Huang, Jin,Chang, Jing-Yu,Woodward, Donald J.,et al. Dynamic neuronal responses in cortical and thalamic areas during different phases of formalin test in rats[J]. EXPERIMENTAL NEUROLOGY,2006,200(1):124-134.
APA Huang, Jin.,Chang, Jing-Yu.,Woodward, Donald J..,Baccala, Luiz A..,Han, Ji-Sheng.,...&F. Luo.(2006).Dynamic neuronal responses in cortical and thalamic areas during different phases of formalin test in rats.EXPERIMENTAL NEUROLOGY,200(1),124-134.
MLA Huang, Jin,et al."Dynamic neuronal responses in cortical and thalamic areas during different phases of formalin test in rats".EXPERIMENTAL NEUROLOGY 200.1(2006):124-134.
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