Dynamic neuronal responses in cortical and thalamic areas during different phases of formalin test in rats
Huang, Jin; Chang, Jing-Yu; Woodward, Donald J.; Baccala, Luiz A.; Han, Ji-Sheng; Wang, Jin-Yan; Luo, Fel; F. Luo
2006-07-01
发表期刊EXPERIMENTAL NEUROLOGY
ISSN0014-4886
文章类型Article
卷号200期号:1页码:124-134
摘要Although formalin-induced activity in primary afferent fibers and spinal dorsal horn is well described, the forebrain neural basis underlying each phase of behavior in formalin test has not yet been clarified. The present study was designed to investigate the cortical and thalamic neuronal responses and interactions among forebrain areas during different phases after subcutaneous injection of formalin. Formalin-induced neuronal activities were simultaneously recorded from primary somatosensory cortex (SI), anterior cingulate cortex (ACC) and medial dorsal (MD) and ventral posterior (VP) thalamus during different phases (i.e., first phase, interphase, second phase and third recovery phase starting from 70 min after injection) of formalin test, using a multi-channel, single-unit recording technique. Our results showed that, (i) unlike the responses in primary afferent fibers and spinal dorsal horn, many forebrain neurons displayed monophasic excitatory responses in the first hour after formalin injection, except a small portion of neurons which exhibited biphasic responses; (ii) the response patterns of many cortical and thalamic neurons changed from excitatory to inhibitory at the end of the second phase; (iii) the direction of information flow also changed dramatically, i.e., from cortex to thalamus and from the medial to the lateral pathway in the first hour, but reversed in phase 3. These results indicate that the changes of activity pattern in forebrain networks may underlie the emerging and subsiding of central sensitization-induced pain behavior in the second phase of formalin test.; Although formalin-induced activity in primary afferent fibers and spinal dorsal horn is well described, the forebrain neural basis underlying each phase of behavior in formalin test has not yet been clarified. The present study was designed to investigate the cortical and thalamic neuronal responses and interactions among forebrain areas during different phases after subcutaneous injection of formalin. Formalin-induced neuronal activities were simultaneously recorded from primary somatosensory cortex (SI), anterior cingulate cortex (ACC) and medial dorsal (MD) and ventral posterior (VP) thalamus during different phases (i.e., first phase, interphase, second phase and third recovery phase starting from 70 min after injection) of formalin test, using a multi-channel, single-unit recording technique. Our results showed that, (i) unlike the responses in primary afferent fibers and spinal dorsal horn, many forebrain neurons displayed monophasic excitatory responses in the first hour after formalin injection, except a small portion of neurons which exhibited biphasic responses; (ii) the response patterns of many cortical and thalamic neurons changed from excitatory to inhibitory at the end of the second phase; (iii) the direction of information flow also changed dramatically, i.e., from cortex to thalamus and from the medial to the lateral pathway in the first hour, but reversed in phase 3. These results indicate that the changes of activity pattern in forebrain networks may underlie the emerging and subsiding of central sensitization-induced pain behavior in the second phase of formalin test. (c) 2006 Elsevier Inc. All rights reserved.
关键词formalin primary somatosensory cortex anterior cingulate cortex thalamus nociception
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000239503000014
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5335
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者F. Luo
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Neurosci Res Inst, Beijing, Peoples R China
3.Wake Forest Univ Hlth Sci, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA
4.Univ Sao Paulo, Escola Politecn, Sao Paulo, Brazil
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Huang, Jin,Chang, Jing-Yu,Woodward, Donald J.,et al. Dynamic neuronal responses in cortical and thalamic areas during different phases of formalin test in rats[J]. EXPERIMENTAL NEUROLOGY,2006,200(1):124-134.
APA Huang, Jin.,Chang, Jing-Yu.,Woodward, Donald J..,Baccala, Luiz A..,Han, Ji-Sheng.,...&F. Luo.(2006).Dynamic neuronal responses in cortical and thalamic areas during different phases of formalin test in rats.EXPERIMENTAL NEUROLOGY,200(1),124-134.
MLA Huang, Jin,et al."Dynamic neuronal responses in cortical and thalamic areas during different phases of formalin test in rats".EXPERIMENTAL NEUROLOGY 200.1(2006):124-134.
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