Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study

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	Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study
	Qiao, Zhi-Mei 2; Wang, Jin-Yan1 ; Han, Ji-Sheng 2; Luo, Fei1,2 ; F. Luo
摘要	(1) Field potential study in conscious rats provides a convenient and effective animal model for pain mechanism and pharmacological research. However, the spatial-temporal character of nociception processing in cortex revealed by field potential technique in conscious rats remains unclear. (2) In the present study, multi-channel field potentials evoked by noxious laser stimulation applied to the hind paw of conscious rats were recorded through 12 chronically implanted skull electrodes. Independent component analysis (ICA) was used to remove possible artifacts and to extract the specific nociception-related component. (3) Two fast sharp responses and one slow blunt response were evoked by noxious laser stimulation. Systemic morphine (5 mg/kg, i.p.) preferentially attenuated the amplitude of the slow blunt response while had no significant effect on the first two sharp responses. ICA revealed that those responses came from activities of contralateral anterior parietal area, medial frontal area and posterior parietal area. A movement artifact was also detected in this study. Partial directed coherence (PDC) analysis showed that there were changes of information flows from medial frontal and posterior parietal area to anterior parietal area after noxious laser stimulation. (4) Characterization of the spatio-temporal responses to noxious laser stimulation may be a valuable model for the study of pain mechanisms and for the assessment of analgesia.; (1) Field potential study in conscious rats provides a convenient and effective animal model for pain mechanism and pharmacological research. However, the spatial-temporal character of nociception processing in cortex revealed by field potential technique in conscious rats remains unclear. (2) In the present study, multi-channel field potentials evoked by noxious laser stimulation applied to the hind paw of conscious rats were recorded through 12 chronically implanted skull electrodes. Independent component analysis (ICA) was used to remove possible artifacts and to extract the specific nociception-related component. (3) Two fast sharp responses and one slow blunt response were evoked by noxious laser stimulation. Systemic morphine (5 mg/kg, i.p.) preferentially attenuated the amplitude of the slow blunt response while had no significant effect on the first two sharp responses. ICA revealed that those responses came from activities of contralateral anterior parietal area, medial frontal area and posterior parietal area. A movement artifact was also detected in this study. Partial directed coherence (PDC) analysis showed that there were changes of information flows from medial frontal and posterior parietal area to anterior parietal area after noxious laser stimulation. (4) Characterization of the spatio-temporal responses to noxious laser stimulation may be a valuable model for the study of pain mechanisms and for the assessment of analgesia.
关键词	laser stimulation nociception independent component analysis morphine conscious rat primary somatosensory cortex
学科领域	生理心理学/生物心理学
	2008-08-01
语种	英语
发表期刊	CELLULAR AND MOLECULAR NEUROBIOLOGY
ISSN	0272-4340
卷号	28 期号:5 页码:671-687
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000257223300005
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5337
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	F. Luo
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Qiao, Zhi-Mei,Wang, Jin-Yan,Han, Ji-Sheng,et al. Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2008,28(5):671-687.
APA	Qiao, Zhi-Mei,Wang, Jin-Yan,Han, Ji-Sheng,Luo, Fei,&F. Luo.(2008).Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study.CELLULAR AND MOLECULAR NEUROBIOLOGY,28(5),671-687.
MLA	Qiao, Zhi-Mei,et al."Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study".CELLULAR AND MOLECULAR NEUROBIOLOGY 28.5(2008):671-687.

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