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Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study
Qiao, Zhi-Mei2; Wang, Jin-Yan1; Han, Ji-Sheng2; Luo, Fei1,2; F. Luo
2008-08-01
Source PublicationCELLULAR AND MOLECULAR NEUROBIOLOGY
ISSN0272-4340
SubtypeArticle
Volume28Issue:5Pages:671-687
Abstract(1) Field potential study in conscious rats provides a convenient and effective animal model for pain mechanism and pharmacological research. However, the spatial-temporal character of nociception processing in cortex revealed by field potential technique in conscious rats remains unclear. (2) In the present study, multi-channel field potentials evoked by noxious laser stimulation applied to the hind paw of conscious rats were recorded through 12 chronically implanted skull electrodes. Independent component analysis (ICA) was used to remove possible artifacts and to extract the specific nociception-related component. (3) Two fast sharp responses and one slow blunt response were evoked by noxious laser stimulation. Systemic morphine (5 mg/kg, i.p.) preferentially attenuated the amplitude of the slow blunt response while had no significant effect on the first two sharp responses. ICA revealed that those responses came from activities of contralateral anterior parietal area, medial frontal area and posterior parietal area. A movement artifact was also detected in this study. Partial directed coherence (PDC) analysis showed that there were changes of information flows from medial frontal and posterior parietal area to anterior parietal area after noxious laser stimulation. (4) Characterization of the spatio-temporal responses to noxious laser stimulation may be a valuable model for the study of pain mechanisms and for the assessment of analgesia.; (1) Field potential study in conscious rats provides a convenient and effective animal model for pain mechanism and pharmacological research. However, the spatial-temporal character of nociception processing in cortex revealed by field potential technique in conscious rats remains unclear. (2) In the present study, multi-channel field potentials evoked by noxious laser stimulation applied to the hind paw of conscious rats were recorded through 12 chronically implanted skull electrodes. Independent component analysis (ICA) was used to remove possible artifacts and to extract the specific nociception-related component. (3) Two fast sharp responses and one slow blunt response were evoked by noxious laser stimulation. Systemic morphine (5 mg/kg, i.p.) preferentially attenuated the amplitude of the slow blunt response while had no significant effect on the first two sharp responses. ICA revealed that those responses came from activities of contralateral anterior parietal area, medial frontal area and posterior parietal area. A movement artifact was also detected in this study. Partial directed coherence (PDC) analysis showed that there were changes of information flows from medial frontal and posterior parietal area to anterior parietal area after noxious laser stimulation. (4) Characterization of the spatio-temporal responses to noxious laser stimulation may be a valuable model for the study of pain mechanisms and for the assessment of analgesia.
Keywordlaser stimulation nociception independent component analysis morphine conscious rat primary somatosensory cortex
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000257223300005
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5337
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorF. Luo
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Qiao, Zhi-Mei,Wang, Jin-Yan,Han, Ji-Sheng,et al. Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2008,28(5):671-687.
APA Qiao, Zhi-Mei,Wang, Jin-Yan,Han, Ji-Sheng,Luo, Fei,&F. Luo.(2008).Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study.CELLULAR AND MOLECULAR NEUROBIOLOGY,28(5),671-687.
MLA Qiao, Zhi-Mei,et al."Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study".CELLULAR AND MOLECULAR NEUROBIOLOGY 28.5(2008):671-687.
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