Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study
Qiao, Zhi-Mei2; Wang, Jin-Yan1; Han, Ji-Sheng2; Luo, Fei1,2; F. Luo
2008-08-01
发表期刊CELLULAR AND MOLECULAR NEUROBIOLOGY
ISSN0272-4340
文章类型Article
卷号28期号:5页码:671-687
摘要(1) Field potential study in conscious rats provides a convenient and effective animal model for pain mechanism and pharmacological research. However, the spatial-temporal character of nociception processing in cortex revealed by field potential technique in conscious rats remains unclear. (2) In the present study, multi-channel field potentials evoked by noxious laser stimulation applied to the hind paw of conscious rats were recorded through 12 chronically implanted skull electrodes. Independent component analysis (ICA) was used to remove possible artifacts and to extract the specific nociception-related component. (3) Two fast sharp responses and one slow blunt response were evoked by noxious laser stimulation. Systemic morphine (5 mg/kg, i.p.) preferentially attenuated the amplitude of the slow blunt response while had no significant effect on the first two sharp responses. ICA revealed that those responses came from activities of contralateral anterior parietal area, medial frontal area and posterior parietal area. A movement artifact was also detected in this study. Partial directed coherence (PDC) analysis showed that there were changes of information flows from medial frontal and posterior parietal area to anterior parietal area after noxious laser stimulation. (4) Characterization of the spatio-temporal responses to noxious laser stimulation may be a valuable model for the study of pain mechanisms and for the assessment of analgesia.; (1) Field potential study in conscious rats provides a convenient and effective animal model for pain mechanism and pharmacological research. However, the spatial-temporal character of nociception processing in cortex revealed by field potential technique in conscious rats remains unclear. (2) In the present study, multi-channel field potentials evoked by noxious laser stimulation applied to the hind paw of conscious rats were recorded through 12 chronically implanted skull electrodes. Independent component analysis (ICA) was used to remove possible artifacts and to extract the specific nociception-related component. (3) Two fast sharp responses and one slow blunt response were evoked by noxious laser stimulation. Systemic morphine (5 mg/kg, i.p.) preferentially attenuated the amplitude of the slow blunt response while had no significant effect on the first two sharp responses. ICA revealed that those responses came from activities of contralateral anterior parietal area, medial frontal area and posterior parietal area. A movement artifact was also detected in this study. Partial directed coherence (PDC) analysis showed that there were changes of information flows from medial frontal and posterior parietal area to anterior parietal area after noxious laser stimulation. (4) Characterization of the spatio-temporal responses to noxious laser stimulation may be a valuable model for the study of pain mechanisms and for the assessment of analgesia.
关键词laser stimulation nociception independent component analysis morphine conscious rat primary somatosensory cortex
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000257223300005
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5337
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者F. Luo
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
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GB/T 7714
Qiao, Zhi-Mei,Wang, Jin-Yan,Han, Ji-Sheng,et al. Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2008,28(5):671-687.
APA Qiao, Zhi-Mei,Wang, Jin-Yan,Han, Ji-Sheng,Luo, Fei,&F. Luo.(2008).Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study.CELLULAR AND MOLECULAR NEUROBIOLOGY,28(5),671-687.
MLA Qiao, Zhi-Mei,et al."Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study".CELLULAR AND MOLECULAR NEUROBIOLOGY 28.5(2008):671-687.
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