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Effects of scopolamine and physostigmine on acquisition of morphine-treated rats in Morris water maze performance
Zheng, XG; Li, XW; Yang, XY; Sui, N; Zheng XiGeng
2002-05-01
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN1671-4083
SubtypeArticle
Volume23Issue:5Pages:477-480
AbstractAIM: To investigate effects of morphine on acquisition process of rats a nd interactions of opioid and cholinergic systems by Morris water maze performance.METHODS: Morris water maze was used to measure the latency of rats with drug s treatment to find the covert platform.RESULTS: Chronic morphine administration (10 mg/kg) impaired the acquisition process of rats in Morris water maze task. Appreciable difference was identified with morphine 10 mg/k g group compared with morphine 3 mg/kg group. Co-administration of morphine (10 mg/kg) and scopolamine (3 mg/kg) aggravated acquisition impairment induced by morphine 1 0 mg/kg or scopolamine alone, though scopolamine itself induced no salient changes in acquisition capabilities of rats. In addition, physostigmine (0.1 mg/kg) could appreciably attenuate morphine-induced acquisition impairment.CONCLUSION: Morphine 10 mg/kg evidently impaired acquisition process of rats. There was a close relationship between the acquisition capabilities of morphine-treated rats and the functions of cholinergic system.; AIM: To investigate effects of morphine on acquisition process of rats and interactions of opioid and cholinergic systems by Morris water maze performance. METHODS: Morris water maze was used to measure the latency of ruts With drugs treatment to find the covert platform. RESULTS: Chronic morphine administration (10 mg/kg) impaired the acquisition process of rats in Morris water maze task. Appreciable difference was identified With morphine 10 mg/kg group compared with morphine 3 mg/kg group. Co-administration of morphine ( 10 mg/kg) and scopolamine (3 mg/kg) aggravated acquisition impairment induced by morphine 10 mg/kg or scopolamine alone, though scopolamine itself induced no salient changes in acquisition capabilities of rats. In addition, physostigmine (0.1 mg/kg) could appreciably attenuate morphine-induced acquisition impairment. CONCLUSION: Morphine 10 mg/kg evidently impaired acquisition process of rats. There was a close relationship between the acquisition capabilities of morphine-treated rats and the functions of cholinergic system.
Keywordmorphine acquisition scopolamine physostigmine Morris water maze
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000175399400016
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5363
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorZheng XiGeng
Affiliation1.Chinese Acad Sci, Inst Psychol, Brain & Behav Res Ctr, Beijing 100101, Peoples R China
2.Henan Univ, Dept Psychol, Kaifeng 475001, Peoples R China
Recommended Citation
GB/T 7714
Zheng, XG,Li, XW,Yang, XY,et al. Effects of scopolamine and physostigmine on acquisition of morphine-treated rats in Morris water maze performance[J]. ACTA PHARMACOLOGICA SINICA,2002,23(5):477-480.
APA Zheng, XG,Li, XW,Yang, XY,Sui, N,&Zheng XiGeng.(2002).Effects of scopolamine and physostigmine on acquisition of morphine-treated rats in Morris water maze performance.ACTA PHARMACOLOGICA SINICA,23(5),477-480.
MLA Zheng, XG,et al."Effects of scopolamine and physostigmine on acquisition of morphine-treated rats in Morris water maze performance".ACTA PHARMACOLOGICA SINICA 23.5(2002):477-480.
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