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Enhanced visuomotor associative learning following stimulation of alpha(2A)-adrenoceptors in the ventral prefrontal cortex in monkeys
Wang, M; Tang, ZX; Li, BM; Bao-Ming Li
2004-10-22
Source PublicationBRAIN RESEARCH
ISSN0006-8993
SubtypeArticle
Volume1024Issue:1-2Pages:176-182
AbstractThe present study investigated the effect of locally infused guanfacine, an α2A-adrenergic agonist, into the ventral prefrontal cortex (PFv) on visuomotor associative learning. Two monkeys were well trained on a two-problem visuomotor associative task: the monkeys performed movement A if presented with a circle pattern, or movement B if presented with a triangle pattern. For learning of new visuomotor associations, the monkeys were presented with a new set of four patterns in each and every daily session, two of which instructed movement A and the other two movement B. Bilaterally infused guanfacine (2.5 μg/μl; 3 μl on each side) improved the monkeys' ability to learn new visuomotor associations: trials and errors to learning criterion of 90% correct decreased significantly. The monkeys showed an enhanced capability to use win–stay/lose–shift strategy on ‘repeat trials’ and change–stay/change–shift strategy on ‘change trials.’ The present results indicate that α2A-adrenoceptor in the PFv is involved in regulating visuomotor associative learning.; The present study investigated the effect of locally infused guanfacine, an alpha(2A)-adrenergic agonist, into the ventral prefrontal cortex (PFv) on visuomotor associative learning. Two monkeys were well trained on a two-problem visuomotor associative task: the monkeys performed movement A if presented with a circle pattern, or movement B if presented with a triangle pattern. For learning of new visuomotor associations, the monkeys were presented with a new set of four patterns in each and every daily session, two of which instructed movement A and the other two movement B. Bilaterally infused guanfacine (2.5 mug/mul; 3 mul on each side) improved the monkeys' ability to learn new visuomotor associations: trials and errors to learning criterion of 90% correct decreased significantly. The monkeys showed an enhanced capability to use win-stay/lose-shift strategy on `repeat trials' and change-stay/change-shift strategy on 'change trials.' The present results indicate that alpha(2A)-adrenoceptor in the PFv is involved in regulating visuomotor associative learning. (C) 2004 Elsevier B.V. All rights reserved.
Keywordguanfacine alpha(2A)-adrenoceptor ventral prefrontal cortex visuomotor associative learning monkey
Subject Area生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000224664800019
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5379
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorBao-Ming Li
Affiliation1.Fudan Univ, Inst Neurobiol, Lab Higher Brain Funct, Shanghai 200433, Peoples R China
2.Guangxi Normal Univ, Coll Life Sci, Guilin 541004, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Wang, M,Tang, ZX,Li, BM,et al. Enhanced visuomotor associative learning following stimulation of alpha(2A)-adrenoceptors in the ventral prefrontal cortex in monkeys[J]. BRAIN RESEARCH,2004,1024(1-2):176-182.
APA Wang, M,Tang, ZX,Li, BM,&Bao-Ming Li.(2004).Enhanced visuomotor associative learning following stimulation of alpha(2A)-adrenoceptors in the ventral prefrontal cortex in monkeys.BRAIN RESEARCH,1024(1-2),176-182.
MLA Wang, M,et al."Enhanced visuomotor associative learning following stimulation of alpha(2A)-adrenoceptors in the ventral prefrontal cortex in monkeys".BRAIN RESEARCH 1024.1-2(2004):176-182.
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