Enhancement of antibody production and expression of c-Fos in the insular cortex in response to a conditioned stimulus after a single-trial learning paradigm
Chen, H; Lin, WJ; Wang, WW; Shao, F; Yang, J; Wang, BR; Kuang, F; Duan, XL; Ju, G; Wenjuan Lin
2004-10-05
发表期刊BEHAVIOURAL BRAIN RESEARCH
通讯作者邮箱linwj@psych.ac.cn
ISSN0166-4328
文章类型Article
卷号154期号:2页码:557-565
产权排序1
摘要

Immune responses can be modulated by Pavlovian conditioning techniques. In this study, to evaluate the conditionability of antibody response via a sin.-le-trial conditioning paradigm, we used a protein antigen ovalbumin as an unconditioned stimulus (UCS) that was paired with a novel taste of saccharin in a single-trial learning protocol. A significant enhancement of anti-ovalbumin antibody production was observed in the conditioned rats at Days 15, 20 and 25 after re-exposure to the conditioned Stimulus. The pattern of conditioned antibody response is similar to that of antigen-induced antibody response. Furthermore, to identify the involvement of a limbic brain structure in the expression of conditioned antibody response, immediate-early gene c-fos expression was used as a marker of neuronal activation to detect the functional activation in the insular cortex (IC) in response to the conditioned stimulus. The re-exposure of conditioned rats to the conditioned stimulus resulted in a significant increase of c-Fos immunoreactivity in all three areas of the IC including the agranular, dysgranular, and granular areas, suggesting that IC is involved in the neural mechanism of expression of conditioned immune response.

关键词Pavlovian Conditioning Rats Antibodies C-fos Insular Cortex
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000224188500029
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5381
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Wenjuan Lin
作者单位1.Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China
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Chen, H,Lin, WJ,Wang, WW,et al. Enhancement of antibody production and expression of c-Fos in the insular cortex in response to a conditioned stimulus after a single-trial learning paradigm[J]. BEHAVIOURAL BRAIN RESEARCH,2004,154(2):557-565.
APA Chen, H.,Lin, WJ.,Wang, WW.,Shao, F.,Yang, J.,...&Wenjuan Lin.(2004).Enhancement of antibody production and expression of c-Fos in the insular cortex in response to a conditioned stimulus after a single-trial learning paradigm.BEHAVIOURAL BRAIN RESEARCH,154(2),557-565.
MLA Chen, H,et al."Enhancement of antibody production and expression of c-Fos in the insular cortex in response to a conditioned stimulus after a single-trial learning paradigm".BEHAVIOURAL BRAIN RESEARCH 154.2(2004):557-565.
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