Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress

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	Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress
	Qi, Xiaoli1 ; Lin, Wenjuan1 ; Li, Junfa 2; Li, Huanhuan 1; Wang, Weiwen1 ; Wang, Donglin 1; Sun, Meng 1; Wenjuan Lin
摘要	Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-responsive-element-binding protein (CREB) signal system may be involved in the molecular mechanism of depression. The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats. Fluoxetine was administrated to either naive rats or stressed rats for 21 days. The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex. Fluoxetine alleviated the depressive-like behaviors and reversed the disruptions of the P-ERK2 and P-CREB in stressed rats. Fluoxetine also exerted mood-elevating effect and increased the levels of the P-ERK2 and P-CREB in naive rats. These results suggest that the ERK-CREB signal system may be the targets of the antidepressant action of fluoxetine and participate in the neuronal mechanism of depression.; Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-responsive-element-binding protein (CREB) signal system may be involved in the molecular mechanism of depression. The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats. Fluoxetine was administrated to either naive rats or stressed rats for 21 days. The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex. Fluoxetine alleviated the depressive-like behaviors and reversed the disruptions of the P-ERK2 and P-CREB in stressed rats. Fluoxetine also exerted mood-elevating effect and increased the levels of the P-ERK2 and P-CREB in naive rats. These results suggest that the ERK-CREB signal system may be the targets of the antidepressant action of fluoxetine and participate in the neuronal mechanism of depression. (C) 2008 Elsevier Inc. All rights reserved.
关键词	ERK CREB stress antidepressant hippocampus prefrontal cortex
学科领域	生理心理学/生物心理学
	2008-08-01
语种	英语
发表期刊	NEUROBIOLOGY OF DISEASE
ISSN	0969-9961
卷号	31 期号:2 页码:278-285
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000258115700012
引用统计	被引频次：200[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5413
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Wenjuan Lin
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Capital Med Univ, Beijing 100069, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Qi, Xiaoli,Lin, Wenjuan,Li, Junfa,et al. Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress[J]. NEUROBIOLOGY OF DISEASE,2008,31(2):278-285.
APA	Qi, Xiaoli.,Lin, Wenjuan.,Li, Junfa.,Li, Huanhuan.,Wang, Weiwen.,...&Wenjuan Lin.(2008).Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress.NEUROBIOLOGY OF DISEASE,31(2),278-285.
MLA	Qi, Xiaoli,et al."Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress".NEUROBIOLOGY OF DISEASE 31.2(2008):278-285.

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