Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
| Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress | |
Qi, Xiaoli1 ; Lin, Wenjuan1; Li, Junfa2; Li, Huanhuan1; Wang, Weiwen1; Wang, Donglin1; Sun, Meng1; Wenjuan Lin
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| Abstract | Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-responsive-element-binding protein (CREB) signal system may be involved in the molecular mechanism of depression. The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats. Fluoxetine was administrated to either naive rats or stressed rats for 21 days. The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex. Fluoxetine alleviated the depressive-like behaviors and reversed the disruptions of the P-ERK2 and P-CREB in stressed rats. Fluoxetine also exerted mood-elevating effect and increased the levels of the P-ERK2 and P-CREB in naive rats. These results suggest that the ERK-CREB signal system may be the targets of the antidepressant action of fluoxetine and participate in the neuronal mechanism of depression.; Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-responsive-element-binding protein (CREB) signal system may be involved in the molecular mechanism of depression. The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats. Fluoxetine was administrated to either naive rats or stressed rats for 21 days. The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex. Fluoxetine alleviated the depressive-like behaviors and reversed the disruptions of the P-ERK2 and P-CREB in stressed rats. Fluoxetine also exerted mood-elevating effect and increased the levels of the P-ERK2 and P-CREB in naive rats. These results suggest that the ERK-CREB signal system may be the targets of the antidepressant action of fluoxetine and participate in the neuronal mechanism of depression. (C) 2008 Elsevier Inc. All rights reserved. |
| Keyword | ERK CREB stress antidepressant hippocampus prefrontal cortex |
| Subject Area | 生理心理学/生物心理学 |
| 2008-08-01 | |
| Language | 英语 |
| Source Publication | NEUROBIOLOGY OF DISEASE
 |
| ISSN | 0969-9961 |
| Volume | 31Issue:2Pages:278-285 |
| Subtype | Article |
| Indexed By | SCI |
| WOS ID | WOS:000258115700012 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/5413 |
| Collection | 中国科学院心理研究所回溯数据库(1956-2010) |
| Corresponding Author | Wenjuan Lin |
| Affiliation | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Capital Med Univ, Beijing 100069, Peoples R China |
| First Author Affilication | Key Laboratory of Mental Health, CAS |
| Recommended Citation GB/T 7714 | Qi, Xiaoli,Lin, Wenjuan,Li, Junfa,et al. Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress[J]. NEUROBIOLOGY OF DISEASE,2008,31(2):278-285. |
| APA | Qi, Xiaoli.,Lin, Wenjuan.,Li, Junfa.,Li, Huanhuan.,Wang, Weiwen.,...&Wenjuan Lin.(2008).Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress.NEUROBIOLOGY OF DISEASE,31(2),278-285. |
| MLA | Qi, Xiaoli,et al."Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress".NEUROBIOLOGY OF DISEASE 31.2(2008):278-285. |
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