PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress
Qi, Xiaoli1; Lin, Wenjuan1; Li, Junfa2; Li, Huanhuan1; Wang, Weiwen1; Wang, Donglin1; Sun, Meng1; Wenjuan Lin
AbstractOur previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-responsive-element-binding protein (CREB) signal system may be involved in the molecular mechanism of depression. The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats. Fluoxetine was administrated to either naive rats or stressed rats for 21 days. The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex. Fluoxetine alleviated the depressive-like behaviors and reversed the disruptions of the P-ERK2 and P-CREB in stressed rats. Fluoxetine also exerted mood-elevating effect and increased the levels of the P-ERK2 and P-CREB in naive rats. These results suggest that the ERK-CREB signal system may be the targets of the antidepressant action of fluoxetine and participate in the neuronal mechanism of depression.; Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-responsive-element-binding protein (CREB) signal system may be involved in the molecular mechanism of depression. The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats. Fluoxetine was administrated to either naive rats or stressed rats for 21 days. The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex. Fluoxetine alleviated the depressive-like behaviors and reversed the disruptions of the P-ERK2 and P-CREB in stressed rats. Fluoxetine also exerted mood-elevating effect and increased the levels of the P-ERK2 and P-CREB in naive rats. These results suggest that the ERK-CREB signal system may be the targets of the antidepressant action of fluoxetine and participate in the neuronal mechanism of depression. (C) 2008 Elsevier Inc. All rights reserved.
KeywordERK CREB stress antidepressant hippocampus prefrontal cortex
Subject Area生理心理学/生物心理学
2008-08-01
Language英语
Source PublicationNEUROBIOLOGY OF DISEASE
ISSN0969-9961
Volume31Issue:2Pages:278-285
SubtypeArticle
Indexed BySCI
WOS IDWOS:000258115700012
Citation statistics
Cited Times:167[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5413
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorWenjuan Lin
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Capital Med Univ, Beijing 100069, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Qi, Xiaoli,Lin, Wenjuan,Li, Junfa,et al. Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress[J]. NEUROBIOLOGY OF DISEASE,2008,31(2):278-285.
APA Qi, Xiaoli.,Lin, Wenjuan.,Li, Junfa.,Li, Huanhuan.,Wang, Weiwen.,...&Wenjuan Lin.(2008).Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress.NEUROBIOLOGY OF DISEASE,31(2),278-285.
MLA Qi, Xiaoli,et al."Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress".NEUROBIOLOGY OF DISEASE 31.2(2008):278-285.
Files in This Item: Download All
File Name/Size DocType Version Access License
Qi-2008-Fluoxetine i(974KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Qi, Xiaoli]'s Articles
[Lin, Wenjuan]'s Articles
[Li, Junfa]'s Articles
Baidu academic
Similar articles in Baidu academic
[Qi, Xiaoli]'s Articles
[Lin, Wenjuan]'s Articles
[Li, Junfa]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Qi, Xiaoli]'s Articles
[Lin, Wenjuan]'s Articles
[Li, Junfa]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Qi-2008-Fluoxetine increases.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.