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Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality
Zang, YF; Jin, Z; Weng, XC; Zhang, L; Zeng, YW; Yang, L; Wang, YF; Seidman, LJ; Faraone, SV; Yu-Feng Wang
2005-12-01
Source PublicationBRAIN & DEVELOPMENT
ISSN0387-7604
SubtypeArticle
Volume27Issue:8Pages:544-550
AbstractUsing event-related functional magnetic resonance imaging to study the Stroop, effect on both behavioral and brain activation of ADHD children off or on methylphenidate (MPH). Nine ADHD boys (aged 9.8-14.5 years) and 9 age-matched normal controls were included. A Stroop-like paradigm was used. AFNI (Analysis of Functional Neurolmaging) and its Deconvolution Analysis were used in a descriptive comparison between ADHD and control groups. (1) Both behavioral reaction time and brain activation showed Stroop effect in controls but neither was found in ADHD children off MPH. When MPH was administered, the Stroop effect tended to appear. (2) The activation volume (AV) of prefrontal cortex (PFC) in both the neutral (NC) and interference conditions (IQ in ADHD children off MPH was smaller than in controls. AV of anterior cingulate cortex in the IC in ADHD children off MPH was smaller than that in controls, but was similar in the NC to that in controls. AV of the basal ganglia, insula and cerebellum was also smaller in the IC, but was larger in the NC for ADHD children off MPH compared with controls. These findings are consistent with prior findings of hypofrontality in ADHD children and implicate a compensatory network including basal ganglia, insula and cerebellum for relative lower cognitive load tasks.; Using event-related functional magnetic resonance imaging to study the Stroop, effect on both behavioral and brain activation of ADHD children off or on methylphenidate (MPH). Nine ADHD boys (aged 9.8-14.5 years) and 9 age-matched normal controls were included. A Stroop-like paradigm was used. AFNI (Analysis of Functional Neurolmaging) and its Deconvolution Analysis were used in a descriptive comparison between ADHD and control groups. (1) Both behavioral reaction time and brain activation showed Stroop effect in controls but neither was found in ADHD children off MPH. When MPH was administered, the Stroop effect tended to appear. (2) The activation volume (AV) of prefrontal cortex (PFC) in both the neutral (NC) and interference conditions (IQ in ADHD children off MPH was smaller than in controls. AV of anterior cingulate cortex in the IC in ADHD children off MPH was smaller than that in controls, but was similar in the NC to that in controls. AV of the basal ganglia, insula and cerebellum was also smaller in the IC, but was larger in the NC for ADHD children off MPH compared with controls. These findings are consistent with prior findings of hypofrontality in ADHD children and implicate a compensatory network including basal ganglia, insula and cerebellum for relative lower cognitive load tasks. (c) 2005 Elsevier B.V. All rights reserved.
Keywordattention-deficit hyperactivity disorder functional magnetic resonance imaging Stroop effect hypofrontality methylphenidate compensation
Subject Area变态心理学
Indexed BySCI ; SSCI
Language英语
WOS IDWOS:000234199200002
Citation statistics
Cited Times:103[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5429
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorYu-Feng Wang
Affiliation1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.306 Hosp, Dept MRI, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
4.Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA
5.Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA 02138 USA
6.Massachusetts Gen Hosp, Psychiat Serv, Boston, MA 02114 USA
7.Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA
8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100864, Peoples R China
Recommended Citation
GB/T 7714
Zang, YF,Jin, Z,Weng, XC,et al. Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality[J]. BRAIN & DEVELOPMENT,2005,27(8):544-550.
APA Zang, YF.,Jin, Z.,Weng, XC.,Zhang, L.,Zeng, YW.,...&Yu-Feng Wang.(2005).Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality.BRAIN & DEVELOPMENT,27(8),544-550.
MLA Zang, YF,et al."Functional MRI in attention-deficit hyperactivity disorder: Evidence for hypofrontality".BRAIN & DEVELOPMENT 27.8(2005):544-550.
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