Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals
Yuan, Yi2,3; Zhu, Zude4; Shi, Jinfu2; Zou, Zhiling5; Yuan, Fei6; Liu, Yijun7,8; Lee, Tatia M. C.1; Weng, Xuchu2; Tatia M.C. Lee
2009-12-01
发表期刊BRAIN AND COGNITION
ISSN0278-2626
文章类型Article
卷号71期号:3页码:223-228
摘要Numerous studies have documented cognitive impairments and hypoactivity in the prefrontal and anterior cingulate cortices in drug users. However, the relationships between opiate dependence and brain structure changes in heroin users are largely unknown. In the present study, we measured the density of gray matter (DGM) with voxel-based morphometry in 30 lifetime heroin-dependent individuals who had abstained from drug use for 5 months, and 34 healthy participants. The DGM of the prefrontal, temporal and cingulate cortices significantly decreased in heroin addicts relative to the healthy group. Critically, partial correlation analysis, which controlled for age, education and gender factors as well as nicotine use and heroin abstinence duration, showed that the duration of heroin use negatively correlated with the DGM in heroin-dependent individuals. These results provide compelling evidence for structural abnormality in heroin-dependent individuals and further suggest that duration of heroin use is a critical factor leading to brain damage.; Numerous studies have documented cognitive impairments and hypoactivity in the prefrontal and anterior cingulate cortices in drug users. However, the relationships between opiate dependence and brain structure changes in heroin users are largely unknown. In the present study, we measured the density of gray matter (DGM) with voxel-based morphometry in 30 lifetime heroin-dependent individuals who had abstained from drug use for 5 months, and 34 healthy participants. The DGM of the prefrontal, temporal and cingulate cortices significantly decreased in heroin addicts relative to the healthy group. Critically, partial correlation analysis, which controlled for age, education and gender factors as well as nicotine use and heroin abstinence duration, showed that the duration of heroin use negatively correlated with the DGM in heroin-dependent individuals. These results provide compelling evidence for structural abnormality in heroin-dependent individuals and further suggest that duration of heroin use is a critical factor leading to brain damage. (C) 2009 Elsevier Inc. All rights reserved.
关键词Heroin Addiction Gray matter VBM
学科领域变态心理学
收录类别SCI ; SSCI
语种英语
WOS记录号WOS:000271664400006
引用统计
被引频次:70[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5439
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Tatia M.C. Lee
作者单位1.Univ Hong Kong, Neuropsychol Lab, Hong Kong, Hong Kong, Peoples R China
2.Chinese Acad Sci, Lab Higher Brain Funct, Inst Psychol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
4.S China Normal Univ, Dept Psychol, Guangzhou, Guangdong, Peoples R China
5.SW China Normal Univ, Dept Psychol, Chongqing, Peoples R China
6.Wujing Med Coll, Dept Radiol, Tianjin, Peoples R China
7.Univ Florida, Dept Psychiat, Gainesville, FL 32610 USA
8.Univ Florida, McKnight Brain Inst, Gainesville, FL 32610 USA
推荐引用方式
GB/T 7714
Yuan, Yi,Zhu, Zude,Shi, Jinfu,et al. Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals[J]. BRAIN AND COGNITION,2009,71(3):223-228.
APA Yuan, Yi.,Zhu, Zude.,Shi, Jinfu.,Zou, Zhiling.,Yuan, Fei.,...&Tatia M.C. Lee.(2009).Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals.BRAIN AND COGNITION,71(3),223-228.
MLA Yuan, Yi,et al."Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals".BRAIN AND COGNITION 71.3(2009):223-228.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Yuan-2009-Gray matte(320KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yuan, Yi]的文章
[Zhu, Zude]的文章
[Shi, Jinfu]的文章
百度学术
百度学术中相似的文章
[Yuan, Yi]的文章
[Zhu, Zude]的文章
[Shi, Jinfu]的文章
必应学术
必应学术中相似的文章
[Yuan, Yi]的文章
[Zhu, Zude]的文章
[Shi, Jinfu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。