Heat shock protein72 protects hippocampal neurons from apoptosis induced by chronic psychological stress
Yao, Shuqiao; Peng, Min; Zhu, Xiongzhao; Cheng, Ming; Qi, Xiaoli; SHUQIAO YAO
2007
发表期刊INTERNATIONAL JOURNAL OF NEUROSCIENCE
ISSN0020-7454
文章类型Article
卷号117期号:11页码:1551-1564
摘要When exposed to nonlethal heat stress (i.e., heat shock preconditioning), HSP72 expression increased in the mammalian brain. HSP72 enhance the viability of neurons and decrease TUNEL-positive neurons under several kinds of stress ( e. g., ischemic). Chronic psychological stress is a kind of stress that could cause hippocampal neuron apoptosis. But whether overexpression of HSP72 can decrease TUNEL-positive hippocampal neurons caused by chronic psychological stress is unclear. To investigate the possible protective role of HSP72 in decreasing chronic psychological stress-induced hippocampal neuron apoptosis, this study analyzed HSP72 expression, apoptotic neurons in the hippocampus of mice. Adult mice were divided into four groups unstressed group; chronic psychological stress group; heat shock stress group; heat shock preconditioning plus psychological stress group; receiving no experimental stress, chronic psychological stress, heat shock stress, heat shock preconditioning plus psychological stress separately. Mice were killed after one month, two months, or three months of stress. A three-way ANOVA ( psychological stress x heat shock stress x time) revealed a significant effect of heat shock stress in increasing HSP72 expression, decreasing neuronal apoptosis in hippocampus CA3 region caused by chronic psychological stress, and showed that HSP72 protected hippocampus CA3 neurons from chronic psychological stress.; When exposed to nonlethal heat stress (i.e., heat shock preconditioning), HSP72 expression increased in the mammalian brain. HSP72 enhance the viability of neurons and decrease TUNEL-positive neurons under several kinds of stress ( e. g., ischemic). Chronic psychological stress is a kind of stress that could cause hippocampal neuron apoptosis. But whether overexpression of HSP72 can decrease TUNEL-positive hippocampal neurons caused by chronic psychological stress is unclear. To investigate the possible protective role of HSP72 in decreasing chronic psychological stress-induced hippocampal neuron apoptosis, this study analyzed HSP72 expression, apoptotic neurons in the hippocampus of mice. Adult mice were divided into four groups unstressed group; chronic psychological stress group; heat shock stress group; heat shock preconditioning plus psychological stress group; receiving no experimental stress, chronic psychological stress, heat shock stress, heat shock preconditioning plus psychological stress separately. Mice were killed after one month, two months, or three months of stress. A three-way ANOVA ( psychological stress x heat shock stress x time) revealed a significant effect of heat shock stress in increasing HSP72 expression, decreasing neuronal apoptosis in hippocampus CA3 region caused by chronic psychological stress, and showed that HSP72 protected hippocampus CA3 neurons from chronic psychological stress.
关键词apoptosis heat shock stress hippocampus HSP72 psychological stress
学科领域健康心理学
收录类别SCI
语种英语
WOS记录号WOS:000250304000005
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5443
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者SHUQIAO YAO
作者单位1.Ctr S Univ Changasha, 2nd Xianya Hosp, Med Psychol Res, Changsha 410011, Peoples R China
2.Inst Psychol, Chinese Acad Sci, Beijing, Peoples R China
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GB/T 7714
Yao, Shuqiao,Peng, Min,Zhu, Xiongzhao,et al. Heat shock protein72 protects hippocampal neurons from apoptosis induced by chronic psychological stress[J]. INTERNATIONAL JOURNAL OF NEUROSCIENCE,2007,117(11):1551-1564.
APA Yao, Shuqiao,Peng, Min,Zhu, Xiongzhao,Cheng, Ming,Qi, Xiaoli,&SHUQIAO YAO.(2007).Heat shock protein72 protects hippocampal neurons from apoptosis induced by chronic psychological stress.INTERNATIONAL JOURNAL OF NEUROSCIENCE,117(11),1551-1564.
MLA Yao, Shuqiao,et al."Heat shock protein72 protects hippocampal neurons from apoptosis induced by chronic psychological stress".INTERNATIONAL JOURNAL OF NEUROSCIENCE 117.11(2007):1551-1564.
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