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HERC1 polymorphisms: population-specific variations in haplotype composition
Yuasa, Isao1; Umetsu, Kazuo2; Nishimukai, Hiroaki3; Fukumori, Yasuo4; Harihara, Shinji5; Saitou, Naruya6; Jin, Feng7; Chattopadhyay, Prasanta K.8; Henke, Lotte9; Henke, Juergen9; Isao Yuasa
2009-08-01
Source PublicationCELL BIOCHEMISTRY AND FUNCTION
ISSN0263-6484
SubtypeArticle
Volume27Issue:6Pages:402-405
AbstractHuman HERC1 is one of six HERC proteins and may play an important role in intracellular membrane trafficking. The human HERC1 gene is suggested to have been affected by local positive selection. To assess the global frequency distributions of coding and non-coding single nucleotide polymorphisms (SNPs) in the HERC1 gene, we developed a new simultaneous genotyping method for four SNPs, and applied this method to investigate 1213 individuals from 12 global populations. The results confirmed remarked differences in the allele and haplotype frequencies between East Asian and non-East Asian populations. One of the three common haplotypes observed was found to be characteristic of East Asians, who showed a relatively uniform distribution of haplotypes. Information on haplotypes would be useful for testing the function of polymorphisms in the HERC1 gene. This is the first study to investigate the distribution of HERC1 polymorphisms in various populations.; Human HERC1 is one of six HERC proteins and may play an important role in intracellular membrane trafficking. The human HERC1 gene is suggested to have been affected by local positive selection. To assess the global frequency distributions of coding and non-coding single nucleotide polymorphisms (SNPs) in the HERC1 gene, we developed a new simultaneous genotyping method for four SNPs, and applied this method to investigate 1213 individuals from 12 global populations. The results confirmed remarked differences in the allele and haplotype frequencies between East Asian and non-East Asian populations. One of the three common haplotypes observed was found to be characteristic of East Asians, who showed a relatively uniform distribution of haplotypes. Information on haplotypes would be useful for testing the function of polymorphisms in the HERC1 gene. This is the first study to investigate the distribution of HERC1 polymorphisms in various populations. Copyright (C) 2009 John Wiley & Sons, Ltd.
Keywordgenotyping haplotype HERC1 single nucleotide polymorphism population study
Subject Area遗传学
Indexed BySCI
Language英语
WOS IDWOS:000269384800012
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5445
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorIsao Yuasa
Affiliation1.Tottori Univ, Fac Med, Div Legal Med, Yonago, Tottori 6838503, Japan
2.Yamagata Univ, Fac Med, Dept Forens Med, Yamagata 990, Japan
3.Ehime Univ, Sch Med, Div Legal Med, Matsuyama, Ehime 790, Japan
4.Osaka Red Cross Blood Ctr, Osaka, Japan
5.Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 113, Japan
6.Natl Inst Genet, Div Populat Genet, Mishima, Shizuoka 411, Japan
7.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
8.Amity Inst Forens Sci, New Delhi, India
9.Inst Blutgrp Forsch, Cologne, Germany
Recommended Citation
GB/T 7714
Yuasa, Isao,Umetsu, Kazuo,Nishimukai, Hiroaki,et al. HERC1 polymorphisms: population-specific variations in haplotype composition[J]. CELL BIOCHEMISTRY AND FUNCTION,2009,27(6):402-405.
APA Yuasa, Isao.,Umetsu, Kazuo.,Nishimukai, Hiroaki.,Fukumori, Yasuo.,Harihara, Shinji.,...&Isao Yuasa.(2009).HERC1 polymorphisms: population-specific variations in haplotype composition.CELL BIOCHEMISTRY AND FUNCTION,27(6),402-405.
MLA Yuasa, Isao,et al."HERC1 polymorphisms: population-specific variations in haplotype composition".CELL BIOCHEMISTRY AND FUNCTION 27.6(2009):402-405.
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