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High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China
Lui, Su1; Huang, Xiaoqi1,2; Chen, Long1; Tang, Hehan1; Zhang, Tijiang1; Li, Xiuli1; Li, Dongming1; Kuang, Weihong2; Chan, Raymond C.3,4; Mechelli, Andrea5; Sweeney, John A.6; Gong, Qiyong1,7; Qiyong Gong
2009-09-08
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
SubtypeArticle
Volume106Issue:36Pages:15412-15417
AbstractBesides the enormous medical and economic consequences, national disasters, such as the Wenchuan 8.0 earthquake, also pose a risk to the mental health of survivors. In this context, a better understanding is needed of how functional brain systems adapt to severe emotional stress. Previous animal studies have demonstrated the importance of limbic, paralimbic, striatal, and prefrontal structures in stress and fear responses. Human studies, which have focused primarily on patients with clinically established posttraumatic stress disorders, have reported abnormalities in similar brain structures. At present, little is known about potential alterations of brain function in trauma survivors shortly after traumatic events. Here, we show alteration of brain function in a cohort of healthy survivors within 25 days after the Wenchuan earthquake by a recently discovered method known as "resting-state'' functional MRI. The current investigation demonstrates that regional activity in frontolimbic and striatal areas increased significantly and connectivity among limbic and striatal networks was attenuated in our participants who had recently experienced severe emotional trauma. Trauma victims also had a reduced temporal synchronization within the "default mode'' of resting-state brain function, which has been characterized in humans and other species. Taken together, our findings provide evidence that significant alterations in brain function, similar in many ways to those observed in posttraumatic stress disorders, can be seen shortly after major traumatic experiences, highlighting the need for early evaluation and intervention for trauma survivors.; Besides the enormous medical and economic consequences, national disasters, such as the Wenchuan 8.0 earthquake, also pose a risk to the mental health of survivors. In this context, a better understanding is needed of how functional brain systems adapt to severe emotional stress. Previous animal studies have demonstrated the importance of limbic, paralimbic, striatal, and prefrontal structures in stress and fear responses. Human studies, which have focused primarily on patients with clinically established posttraumatic stress disorders, have reported abnormalities in similar brain structures. At present, little is known about potential alterations of brain function in trauma survivors shortly after traumatic events. Here, we show alteration of brain function in a cohort of healthy survivors within 25 days after the Wenchuan earthquake by a recently discovered method known as "resting-state'' functional MRI. The current investigation demonstrates that regional activity in frontolimbic and striatal areas increased significantly and connectivity among limbic and striatal networks was attenuated in our participants who had recently experienced severe emotional trauma. Trauma victims also had a reduced temporal synchronization within the "default mode'' of resting-state brain function, which has been characterized in humans and other species. Taken together, our findings provide evidence that significant alterations in brain function, similar in many ways to those observed in posttraumatic stress disorders, can be seen shortly after major traumatic experiences, highlighting the need for early evaluation and intervention for trauma survivors.
Keywordneuroimaging stress anxiety depression posttraumatic stress disorder
Subject Area健康心理学 ; 生理心理学/生物心理学
Indexed BySCI
Language英语
WOS IDWOS:000269632400060
Citation statistics
Cited Times:110[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5447
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorQiyong Gong
Affiliation1.Sichuan Univ, W China Hosp, Huaxi MR Res Ctr, Dept Radiol, Chengdu 610041, Peoples R China
2.Sichuan Univ, W China Hosp, Dept Psychiat, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
3.Chinese Acad Sci, Inst Psychol Neuropsychol & Appl Cognit Neurosci, Beijing 100011, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100011, Peoples R China
5.Kings Coll London, Inst Psychiat, Div Psychol Med & Psychiat, Sect Neuroimaging, London SE5 8AF, England
6.Univ Illinois, Ctr Cognit Med, Chicago, IL 60612 USA
7.Univ Liverpool, Fac Med, Div Med Imaging, Liverpool L69 3BX, Merseyside, England
Recommended Citation
GB/T 7714
Lui, Su,Huang, Xiaoqi,Chen, Long,et al. High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(36):15412-15417.
APA Lui, Su.,Huang, Xiaoqi.,Chen, Long.,Tang, Hehan.,Zhang, Tijiang.,...&Qiyong Gong.(2009).High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(36),15412-15417.
MLA Lui, Su,et al."High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.36(2009):15412-15417.
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