High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China
Lui, Su1; Huang, Xiaoqi1,2; Chen, Long1; Tang, Hehan1; Zhang, Tijiang1; Li, Xiuli1; Li, Dongming1; Kuang, Weihong2; Chan, Raymond C.3,4; Mechelli, Andrea5; Sweeney, John A.6; Gong, Qiyong1,7; Qiyong Gong
2009-09-08
发表期刊PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
文章类型Article
卷号106期号:36页码:15412-15417
摘要Besides the enormous medical and economic consequences, national disasters, such as the Wenchuan 8.0 earthquake, also pose a risk to the mental health of survivors. In this context, a better understanding is needed of how functional brain systems adapt to severe emotional stress. Previous animal studies have demonstrated the importance of limbic, paralimbic, striatal, and prefrontal structures in stress and fear responses. Human studies, which have focused primarily on patients with clinically established posttraumatic stress disorders, have reported abnormalities in similar brain structures. At present, little is known about potential alterations of brain function in trauma survivors shortly after traumatic events. Here, we show alteration of brain function in a cohort of healthy survivors within 25 days after the Wenchuan earthquake by a recently discovered method known as "resting-state'' functional MRI. The current investigation demonstrates that regional activity in frontolimbic and striatal areas increased significantly and connectivity among limbic and striatal networks was attenuated in our participants who had recently experienced severe emotional trauma. Trauma victims also had a reduced temporal synchronization within the "default mode'' of resting-state brain function, which has been characterized in humans and other species. Taken together, our findings provide evidence that significant alterations in brain function, similar in many ways to those observed in posttraumatic stress disorders, can be seen shortly after major traumatic experiences, highlighting the need for early evaluation and intervention for trauma survivors.; Besides the enormous medical and economic consequences, national disasters, such as the Wenchuan 8.0 earthquake, also pose a risk to the mental health of survivors. In this context, a better understanding is needed of how functional brain systems adapt to severe emotional stress. Previous animal studies have demonstrated the importance of limbic, paralimbic, striatal, and prefrontal structures in stress and fear responses. Human studies, which have focused primarily on patients with clinically established posttraumatic stress disorders, have reported abnormalities in similar brain structures. At present, little is known about potential alterations of brain function in trauma survivors shortly after traumatic events. Here, we show alteration of brain function in a cohort of healthy survivors within 25 days after the Wenchuan earthquake by a recently discovered method known as "resting-state'' functional MRI. The current investigation demonstrates that regional activity in frontolimbic and striatal areas increased significantly and connectivity among limbic and striatal networks was attenuated in our participants who had recently experienced severe emotional trauma. Trauma victims also had a reduced temporal synchronization within the "default mode'' of resting-state brain function, which has been characterized in humans and other species. Taken together, our findings provide evidence that significant alterations in brain function, similar in many ways to those observed in posttraumatic stress disorders, can be seen shortly after major traumatic experiences, highlighting the need for early evaluation and intervention for trauma survivors.
关键词neuroimaging stress anxiety depression posttraumatic stress disorder
学科领域健康心理学 ; 生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000269632400060
引用统计
被引频次:108[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5447
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Qiyong Gong
作者单位1.Sichuan Univ, W China Hosp, Huaxi MR Res Ctr, Dept Radiol, Chengdu 610041, Peoples R China
2.Sichuan Univ, W China Hosp, Dept Psychiat, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
3.Chinese Acad Sci, Inst Psychol Neuropsychol & Appl Cognit Neurosci, Beijing 100011, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100011, Peoples R China
5.Kings Coll London, Inst Psychiat, Div Psychol Med & Psychiat, Sect Neuroimaging, London SE5 8AF, England
6.Univ Illinois, Ctr Cognit Med, Chicago, IL 60612 USA
7.Univ Liverpool, Fac Med, Div Med Imaging, Liverpool L69 3BX, Merseyside, England
推荐引用方式
GB/T 7714
Lui, Su,Huang, Xiaoqi,Chen, Long,et al. High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(36):15412-15417.
APA Lui, Su.,Huang, Xiaoqi.,Chen, Long.,Tang, Hehan.,Zhang, Tijiang.,...&Qiyong Gong.(2009).High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(36),15412-15417.
MLA Lui, Su,et al."High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.36(2009):15412-15417.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Lui-2009-High-field (577KB) 限制开放--浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lui, Su]的文章
[Huang, Xiaoqi]的文章
[Chen, Long]的文章
百度学术
百度学术中相似的文章
[Lui, Su]的文章
[Huang, Xiaoqi]的文章
[Chen, Long]的文章
必应学术
必应学术中相似的文章
[Lui, Su]的文章
[Huang, Xiaoqi]的文章
[Chen, Long]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Lui-2009-High-field MRI revea.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。