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HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese
Wang, Binbin; Jin, Feng; Yang, Ze; Lu, Zeping; Zheng, Chenguang; Wang, Li; Li Wang
2007
Source PublicationDEMENTIA AND GERIATRIC COGNITIVE DISORDERS
ISSN1420-8008
SubtypeArticle
Volume23Issue:5Pages:312-315
AbstractHuman HSPG2 participates in the formation of amyloid and tau aggregation in Alzheimer's disease ( AD). HSPG2 gene is located on a susceptibility region to late-onset AD ( LOAD), and considered as a candidate gene for LOAD because of its function and location. We performed an association study between the HSPG2 Bam H I polymorphism C/A of intron 6 and LOAD on 104 patients and 127 healthy controls of Chinese origin. The C allele was more prominent in LOAD patients than in controls, though the difference was not statistically significant. Likewise with the stratification of APOE epsilon 4 status, no statistical difference was observed between cases and controls. Our findings suggest that this polymorphism may not represent an additional genetic risk factor for LOAD.; Human HSPG2 participates in the formation of amyloid and tau aggregation in Alzheimer's disease ( AD). HSPG2 gene is located on a susceptibility region to late-onset AD ( LOAD), and considered as a candidate gene for LOAD because of its function and location. We performed an association study between the HSPG2 Bam H I polymorphism C/A of intron 6 and LOAD on 104 patients and 127 healthy controls of Chinese origin. The C allele was more prominent in LOAD patients than in controls, though the difference was not statistically significant. Likewise with the stratification of APOE epsilon 4 status, no statistical difference was observed between cases and controls. Our findings suggest that this polymorphism may not represent an additional genetic risk factor for LOAD. Copyright (C) 2007 S. Karger AG, Basel.
Keywordlate-onset Alzheimer's disease apolipoprotein E allele 4 perlecan
Subject Area医学心理学 ; 遗传学
Indexed BySCI
Language英语
WOS IDWOS:000245138100005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5457
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorLi Wang
Affiliation1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Human & Anim Genet, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Res Lab Behav Biol, Beijing 100101, Peoples R China
4.Minist Hlth, Beijing Hosp, Genet Inst, Med Genet Lab, Beijing, Peoples R China
5.Jiangbin Hosp, Nanning, Peoples R China
Recommended Citation
GB/T 7714
Wang, Binbin,Jin, Feng,Yang, Ze,et al. HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese[J]. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,2007,23(5):312-315.
APA Wang, Binbin.,Jin, Feng.,Yang, Ze.,Lu, Zeping.,Zheng, Chenguang.,...&Li Wang.(2007).HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese.DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,23(5),312-315.
MLA Wang, Binbin,et al."HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese".DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 23.5(2007):312-315.
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