HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese
Wang, Binbin; Jin, Feng; Yang, Ze; Lu, Zeping; Zheng, Chenguang; Wang, Li; Li Wang
2007
发表期刊DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
ISSN1420-8008
文章类型Article
卷号23期号:5页码:312-315
摘要Human HSPG2 participates in the formation of amyloid and tau aggregation in Alzheimer's disease ( AD). HSPG2 gene is located on a susceptibility region to late-onset AD ( LOAD), and considered as a candidate gene for LOAD because of its function and location. We performed an association study between the HSPG2 Bam H I polymorphism C/A of intron 6 and LOAD on 104 patients and 127 healthy controls of Chinese origin. The C allele was more prominent in LOAD patients than in controls, though the difference was not statistically significant. Likewise with the stratification of APOE epsilon 4 status, no statistical difference was observed between cases and controls. Our findings suggest that this polymorphism may not represent an additional genetic risk factor for LOAD.; Human HSPG2 participates in the formation of amyloid and tau aggregation in Alzheimer's disease ( AD). HSPG2 gene is located on a susceptibility region to late-onset AD ( LOAD), and considered as a candidate gene for LOAD because of its function and location. We performed an association study between the HSPG2 Bam H I polymorphism C/A of intron 6 and LOAD on 104 patients and 127 healthy controls of Chinese origin. The C allele was more prominent in LOAD patients than in controls, though the difference was not statistically significant. Likewise with the stratification of APOE epsilon 4 status, no statistical difference was observed between cases and controls. Our findings suggest that this polymorphism may not represent an additional genetic risk factor for LOAD. Copyright (C) 2007 S. Karger AG, Basel.
关键词late-onset Alzheimer's disease apolipoprotein E allele 4 perlecan
学科领域医学心理学 ; 遗传学
收录类别SCI
语种英语
WOS记录号WOS:000245138100005
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5457
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Li Wang
作者单位1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Human & Anim Genet, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Res Lab Behav Biol, Beijing 100101, Peoples R China
4.Minist Hlth, Beijing Hosp, Genet Inst, Med Genet Lab, Beijing, Peoples R China
5.Jiangbin Hosp, Nanning, Peoples R China
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Wang, Binbin,Jin, Feng,Yang, Ze,et al. HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese[J]. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,2007,23(5):312-315.
APA Wang, Binbin.,Jin, Feng.,Yang, Ze.,Lu, Zeping.,Zheng, Chenguang.,...&Li Wang.(2007).HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese.DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,23(5),312-315.
MLA Wang, Binbin,et al."HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese".DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 23.5(2007):312-315.
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