Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
| HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese | |
Wang, Binbin; Jin, Feng ; Yang, Ze; Lu, Zeping; Zheng, Chenguang; Wang, Li; Li Wang
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| Abstract | Human HSPG2 participates in the formation of amyloid and tau aggregation in Alzheimer's disease ( AD). HSPG2 gene is located on a susceptibility region to late-onset AD ( LOAD), and considered as a candidate gene for LOAD because of its function and location. We performed an association study between the HSPG2 Bam H I polymorphism C/A of intron 6 and LOAD on 104 patients and 127 healthy controls of Chinese origin. The C allele was more prominent in LOAD patients than in controls, though the difference was not statistically significant. Likewise with the stratification of APOE epsilon 4 status, no statistical difference was observed between cases and controls. Our findings suggest that this polymorphism may not represent an additional genetic risk factor for LOAD.; Human HSPG2 participates in the formation of amyloid and tau aggregation in Alzheimer's disease ( AD). HSPG2 gene is located on a susceptibility region to late-onset AD ( LOAD), and considered as a candidate gene for LOAD because of its function and location. We performed an association study between the HSPG2 Bam H I polymorphism C/A of intron 6 and LOAD on 104 patients and 127 healthy controls of Chinese origin. The C allele was more prominent in LOAD patients than in controls, though the difference was not statistically significant. Likewise with the stratification of APOE epsilon 4 status, no statistical difference was observed between cases and controls. Our findings suggest that this polymorphism may not represent an additional genetic risk factor for LOAD. Copyright (C) 2007 S. Karger AG, Basel. |
| Keyword | late-onset Alzheimer's disease apolipoprotein E allele 4 perlecan |
| Subject Area | 医学心理学 ; 遗传学 |
| 2007 | |
| Language | 英语 |
| Source Publication | DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
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| ISSN | 1420-8008 |
| Volume | 23Issue:5Pages:312-315 |
| Subtype | Article |
| Indexed By | SCI |
| WOS ID | WOS:000245138100005 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/5457 |
| Collection | 中国科学院心理研究所回溯数据库(1956-2010) |
| Corresponding Author | Li Wang |
| Affiliation | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Human & Anim Genet, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Res Lab Behav Biol, Beijing 100101, Peoples R China 4.Minist Hlth, Beijing Hosp, Genet Inst, Med Genet Lab, Beijing, Peoples R China 5.Jiangbin Hosp, Nanning, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Binbin,Jin, Feng,Yang, Ze,et al. HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese[J]. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,2007,23(5):312-315. |
| APA | Wang, Binbin.,Jin, Feng.,Yang, Ze.,Lu, Zeping.,Zheng, Chenguang.,...&Li Wang.(2007).HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese.DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,23(5),312-315. |
| MLA | Wang, Binbin,et al."HSPG2 gene C/A polymorphism does not confer susceptibility to Alzheimer's disease in Chinese".DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 23.5(2007):312-315. |
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