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Involvement of the medial temporal lobe in priming for new associations
Yang, JJ; Weng, XC; Guan, LC; Kuang, PZ; Zhang, MZ; Sun, WJ; Yu, SY; Patterson, K; Xuchu Weng
2003
Source PublicationNEUROPSYCHOLOGIA
ISSN0028-3932
SubtypeArticle
Volume41Issue:7Pages:818-829
AbstractThis study was addressed to the question of whether the medial temporal lobe (MTL) plays a critical role in implicit memory for new associations. Priming for new associations was examined in two different tasks in 18 patients with focal lesions all involving the MTL. In Experiment 1, following a study phase for pairs of unrelated words, subjects performed a perceptual identification task on old, recombined, and new pairs of words presented at brief exposure durations. In contrast to control subjects, and despite a normal level of item priming, the patients failed to show superior identification of the old pairs relative to the recombined pairs, the measure of associative priming. In Experiment 2, subjects engaged in speeded naming of the print color for previously studied words presented in the original color or in a different old color, and for unstudied words. Again, in contrast to control subjects and despite a normal level of item facilitation on color naming reaction time (RT), the patients failed to show priming for recently experienced new associations between words and colors. Explicit recognition memory by the patients was abnormal in both experiments. This study records an absence of priming for new associations, in two different tasks in which the nature of the stimuli was considerably different, in a large group of patients with lesions in the MTL. Although some previous research has reported significant associative priming in other tasks for patients with MTL lesions, the present results suggest that this region is critical for forming new associations of the types assessed here.; This study was addressed to the question of whether the medial temporal lobe (MTL) plays a critical role in implicit memory for new associations. Priming for new associations was examined in two different tasks in 18 patients with focal lesions all involving the MTL. In Experiment 1, following a study phase for pairs of unrelated words, subjects performed a perceptual identification task on old, recombined, and new pairs of words presented at brief exposure durations. In contrast to control subjects, and despite a normal level of item priming, the patients failed to show superior identification of the old pairs relative to the recombined pairs, the measure of associative priming. In Experiment 2, subjects engaged in speeded naming of the print color for previously studied words presented in the original color or in a different old color, and for unstudied words. Again, in contrast to control subjects and despite a normal level of item facilitation on color naming reaction time (RT), the patients failed to show priming for recently experienced new associations between words and colors. Explicit recognition memory by the patients was abnormal in both experiments. This study records an absence of priming for new associations, in two different tasks in which the nature of the stimuli was considerably different, in a large group of patients with lesions in the MTL. Although some previous research has reported significant associative priming in other tasks for patients with MTL lesions, the present results suggest that this region is critical for forming new associations of the types assessed here. (C) 2002 Elsevier Science Ltd. All rights reserved.
Keywordassociative priming medial temporal lobe lesion implicit memory
Subject Area认知神经科学
Indexed BySCI ; SSCI
Language英语
WOS IDWOS:000182056300006
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5505
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorXuchu Weng
Affiliation1.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
2.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
3.Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
4.Chinese PLA Acad Med Sci, Dept Neurosurg, Beijing 100853, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing 100853, Peoples R China
6.MRC, Cognit & Brain Sci Unit, Cambridge CB2 2EF, England
Recommended Citation
GB/T 7714
Yang, JJ,Weng, XC,Guan, LC,et al. Involvement of the medial temporal lobe in priming for new associations[J]. NEUROPSYCHOLOGIA,2003,41(7):818-829.
APA Yang, JJ.,Weng, XC.,Guan, LC.,Kuang, PZ.,Zhang, MZ.,...&Xuchu Weng.(2003).Involvement of the medial temporal lobe in priming for new associations.NEUROPSYCHOLOGIA,41(7),818-829.
MLA Yang, JJ,et al."Involvement of the medial temporal lobe in priming for new associations".NEUROPSYCHOLOGIA 41.7(2003):818-829.
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