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Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication
Tang, Kai-Fu1; Xie, Jing1; Chen, Min1; Liu, Qi1; Zhou, Xi-Yuan2; Zeng, Weiqun1; Huang, Ai-Long1; Zuo, Guo-qing3; Wang, Yan4; Xiang, Rong5; Ren, Hong1; K. F. Tang; H. Ren
2008-05-01
Source PublicationBIOLOGICALS
ISSN1045-1056
SubtypeArticle
Volume36Issue:3Pages:177-183
AbstractRecent studies have demonstrated that the effect of inhibition of HBV replication can be achieved by RNA interference (RNAi) at both the cellular and organismal levels. However, HBV replication cannot be completely inhibited by this method. To completely inhibit HBV replication, new strategies for improving the inhibition efficacy of HBV-specific siRNAs are needed. In this study, we demonstrated that knockdown of damage-specific DNA binding protein 1 (DDB1), a protein involved in nucleotide-excision repair and HBV replication, significantly enhanced the HBx-siRNA-mediated inhibition of HBV replication. Although knockdown of DDB1 may be toxic to normal liver cells, our results indeed suggest a new direction to enhance the efficacy of HBV-siRNA-mediated inhibition of HBV replication.; Recent studies have demonstrated that the effect of inhibition of HBV replication can be achieved by RNA interference (RNAi) at both the cellular and organismal levels. However, HBV replication cannot be completely inhibited by this method. To completely inhibit HBV replication, new strategies for improving the inhibition efficacy of HBV-specific siRNAs are needed. In this study, we demonstrated that knockdown of damage-specific DNA binding protein 1 (DDB1), a protein involved in nucleotide-excision repair and HBV replication, significantly enhanced the HBx-siRNA-mediated inhibition of HBV replication. Although knockdown of DDB1 may be toxic to normal liver cells, our results indeed suggest a new direction to enhance the efficacy of HBV-siRNA-mediated inhibition of HBV replication. (C) 2007 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.
Keywordhepatitis B virus RNAi damage-specific DNA binding protein 1
Subject Area分子生物学
Indexed BySCI
Language英语
WOS IDWOS:000255548000004
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5513
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorK. F. Tang; H. Ren
Affiliation1.Chongqing Univ Med Sci, Affiliated Hosp 2, Inst Viral Hepatitis, Minist Educ,Key Lab Mol Biol Infect Dis, Chongqing 400010, Peoples R China
2.Chongqing Med Univ, Affiliated Hosp 2, Dept Ophthalmol, Chongqing 400010, Peoples R China
3.Chongqing Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Chongqing 400010, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
5.Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
Recommended Citation
GB/T 7714
Tang, Kai-Fu,Xie, Jing,Chen, Min,et al. Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication[J]. BIOLOGICALS,2008,36(3):177-183.
APA Tang, Kai-Fu.,Xie, Jing.,Chen, Min.,Liu, Qi.,Zhou, Xi-Yuan.,...&H. Ren.(2008).Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication.BIOLOGICALS,36(3),177-183.
MLA Tang, Kai-Fu,et al."Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication".BIOLOGICALS 36.3(2008):177-183.
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