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Magnetization transfer imaging reveals the brain deficit in patients with treatment-refractory depression
Zhang, Ti-Jiang1,2; Wu, Qi-Zhu1; Huang, Xiao-Qi1; Sun, Xue-Li3; Zou, Ke3; Lui, Su1; Liu, Fei4; Hu, Jun-Mei5; Kuang, Wei-Hong3; Li, Dong-Ming1; Li, Fei1; Chen, Hua-Fu4; Chan, Raymond C. K.6,7; Mechelli, Andrea8; Gong, Qi-Yong1,9; Q. Y. Gong
2009-10-01
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
SubtypeArticle
Volume117Issue:3Pages:157-161
AbstractBackground: Studies on treatment resistant depression (TRD) using advanced magnetic resonance imaging techniques are very limited. Methods: A group of 15 patients with clinically defined TRD and 15 matched healthy controls underwent magnetization transfer imaging (MTI) and T1-weighted (T1W) imaging. MTI data were processed and analyzed voxel-wised in SPM2. A voxel based morphometric (VBM) analysis was performed using T1W images. Results: Reduced magnetization transfer ratio was observed in the TRD group relative to normal controls in the anterior cingulate, insula, caudate tail and amygdala-parahippocampal areas. All these regions were identified within the right hemisphere. VBM revealed no morphological abnormalities in the TRD group compared to the control group. Negative correlations were found between MRI and clinical measures in the inferior temporal gyrus. Limitations: The cross-sectional design and small sample size. Conclusions: The findings suggest that MTI is capable of identifying subtle brain abnormalities which underlie TRD and in general more sensitive than morphological measures.; Background: Studies on treatment resistant depression (TRD) using advanced magnetic resonance imaging techniques are very limited.
KeywordTreatment resistant/refractory depression Magnetization transfer imaging Magnetization transfer ratio Limbic system Striatal nucleus
Subject Area认知神经科学
Indexed BySCI ; SSCI
Language英语
WOS IDWOS:000270245500005
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5533
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorQ. Y. Gong
Affiliation1.Sichuan Univ, HMRRC, Dept Radiol, W China Hosp, Chengdu 610041, Peoples R China
2.Affiliated Hosp, Zunyi Med Coll, Guizhou, Peoples R China
3.Sichuan Univ, W China Hosp, Dept Psychiat, Chengdu 610041, Peoples R China
4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu 610054, Peoples R China
5.Sichuan Univ, Dept Forens Psychiat, Sch Primary Med & Forens Med, Chengdu 610041, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
7.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
8.Kings Coll London, Inst Psychiat, Div Psychol Med, Sect Neuroimaging, London, England
9.Univ Liverpool, Fac Med, Div Med Imaging, Liverpool L69 3BX, Merseyside, England
Recommended Citation
GB/T 7714
Zhang, Ti-Jiang,Wu, Qi-Zhu,Huang, Xiao-Qi,et al. Magnetization transfer imaging reveals the brain deficit in patients with treatment-refractory depression[J]. JOURNAL OF AFFECTIVE DISORDERS,2009,117(3):157-161.
APA Zhang, Ti-Jiang.,Wu, Qi-Zhu.,Huang, Xiao-Qi.,Sun, Xue-Li.,Zou, Ke.,...&Q. Y. Gong.(2009).Magnetization transfer imaging reveals the brain deficit in patients with treatment-refractory depression.JOURNAL OF AFFECTIVE DISORDERS,117(3),157-161.
MLA Zhang, Ti-Jiang,et al."Magnetization transfer imaging reveals the brain deficit in patients with treatment-refractory depression".JOURNAL OF AFFECTIVE DISORDERS 117.3(2009):157-161.
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