Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
| MethyCancer: the database of human DNA methylation and cancer | |
He, Ximiao1,2; Chang, Suhua1 ; Zhang, Jiajie1,2; Zhao, Qian1,2; Xiang, Haizhen1; Kusonmano, Kanthida1,3,4; Yang, Liu5,6; Sun, Zhong Sheng5; Yang, Huanming1; Wang, Jing1; J. Wang
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| 摘要 | Cancer is ranked as one of the top killers in all human diseases and continues to have a devastating effect on the population around the globe. Current research efforts are aiming to accelerate our understanding of the molecular basis of cancer and develop effective means for cancer diagnostics, treatment and prognosis. An altered pattern of epigenetic modifications, most importantly DNA methylation events, plays a critical role in tumorigenesis through regulating oncogene activation, tumor suppressor gene silencing and chromosomal instability. To study interplay of DNA methylation, gene expression and cancer, we developed a publicly accessible database for human DNA Methylation and Cancer (MethyCancer, http:; Cancer is ranked as one of the top killers in all human diseases and continues to have a devastating effect on the population around the globe. Current research efforts are aiming to accelerate our understanding of the molecular basis of cancer and develop effective means for cancer diagnostics, treatment and prognosis. An altered pattern of epigenetic modifications, most importantly DNA methylation events, plays a critical role in tumorigenesis through regulating oncogene activation, tumor suppressor gene silencing and chromosomal instability. To study interplay of DNA methylation, gene expression and cancer, we developed a publicly accessible database for human DNA Methylation and Cancer (MethyCancer, http://methycancer.genomics.org.cn). MethyCancer hosts both highly integrated data of DNA methylation, cancer-related gene, mutation and cancer information from public resources, and the CpG Island (CGI) clones derived from our large-scale sequencing. Interconnections between different data types were analyzed and presented. Furthermore, a powerful search tool is developed to provide user-friendly access to all the data and data connections. A graphical MethyView shows DNA methylation in context of genomics and genetics data facilitating the research in cancer to understand genetic and epigenetic mechanisms that make dramatic changes in gene expression of tumor cells. |
| 关键词 | integrated information resource cpg-islands human genome hypomethylation gene hypermethylation retinoblastoma chromosome-22 epigenomics epigenetics |
| 学科领域 | 系统生物学/生物信息学 |
| 2008 | |
| 语种 | 英语 |
| 发表期刊 | NUCLEIC ACIDS RESEARCH
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| ISSN | 0305-1048 |
| 卷号 | 36页码:D836-D841 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| WOS记录号 | WOS:000252545400148 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/5541 |
| 专题 | 中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | J. Wang |
| 作者单位 | 1.Chinese Acad Sci, Beijing Inst Genom, Beijing 101300, Peoples R China 2.Grad Univ, Chinese Acad Sci, Beijing 100039, Peoples R China 3.King Mongkuts Univ Technol, Sch Informat Technol, Bangkok 10140, Thailand 4.King Mongkuts Univ Technol, Sch Bioresources & Technol, Bionformat Program, Bangkok 10140, Thailand 5.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 101300, Peoples R China 6.Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310007, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Ximiao,Chang, Suhua,Zhang, Jiajie,et al. MethyCancer: the database of human DNA methylation and cancer[J]. NUCLEIC ACIDS RESEARCH,2008,36:D836-D841. |
| APA | He, Ximiao.,Chang, Suhua.,Zhang, Jiajie.,Zhao, Qian.,Xiang, Haizhen.,...&J. Wang.(2008).MethyCancer: the database of human DNA methylation and cancer.NUCLEIC ACIDS RESEARCH,36,D836-D841. |
| MLA | He, Ximiao,et al."MethyCancer: the database of human DNA methylation and cancer".NUCLEIC ACIDS RESEARCH 36(2008):D836-D841. |
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