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Mismatch negativity to the patient's own name in chronic disorders of consciousness
Qin, Pengmin1; Di, Haibo2; Yan, Xiaodan1; Yuc, Senming3; Yu, Dan3; Laureys, Steven4,5; Weng, Xuchu1; X. C. Weng
2008-12-19
Source PublicationNEUROSCIENCE LETTERS
ISSN0304-3940
SubtypeArticle
Volume448Issue:1Pages:24-28
AbstractPrevious studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (> 1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4). vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness.; Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (> 1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4). vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
KeywordMismatch negativity Disorders of consciousness Vegetative state Minimally conscious state Own name
Subject Area认知神经科学
Indexed BySCI
Language英语
WOS IDWOS:000261553800006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5543
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorX. C. Weng
Affiliation1.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
2.Hangzhou Normal Univ, Hangzhou, Zhejiang, Peoples R China
3.Wujing Hosp Hangzhou City, Rehabil Ctr Brain Damage, Hangzhou, Zhejiang, Peoples R China
4.Univ Liege, Coma Sci Grp, Cyclotron Res Ctr, Liege, Belgium
5.Univ Liege, Dept Neurol, Liege, Belgium
Recommended Citation
GB/T 7714
Qin, Pengmin,Di, Haibo,Yan, Xiaodan,et al. Mismatch negativity to the patient's own name in chronic disorders of consciousness[J]. NEUROSCIENCE LETTERS,2008,448(1):24-28.
APA Qin, Pengmin.,Di, Haibo.,Yan, Xiaodan.,Yuc, Senming.,Yu, Dan.,...&X. C. Weng.(2008).Mismatch negativity to the patient's own name in chronic disorders of consciousness.NEUROSCIENCE LETTERS,448(1),24-28.
MLA Qin, Pengmin,et al."Mismatch negativity to the patient's own name in chronic disorders of consciousness".NEUROSCIENCE LETTERS 448.1(2008):24-28.
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