Mismatch negativity to the patient's own name in chronic disorders of consciousness

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Mismatch negativity to the patient's own name in chronic disorders of consciousness
	Qin, Pengmin 1; Di, Haibo 2; Yan, Xiaodan 1; Yuc, Senming 3; Yu, Dan 3; Laureys, Steven 4,5; Weng, Xuchu1 ; X. C. Weng
摘要	Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (> 1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4). vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness.; Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (> 1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n = 4). vegetative state (VS, n = 6), and minimally conscious state (MCS, n = 2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
关键词	Mismatch negativity Disorders of consciousness Vegetative state Minimally conscious state Own name
学科领域	认知神经科学
	2008-12-19
语种	英语
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	448 期号:1 页码:24-28
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000261553800006
引用统计	被引频次：81[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5543
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	X. C. Weng
作者单位	1.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China 2.Hangzhou Normal Univ, Hangzhou, Zhejiang, Peoples R China 3.Wujing Hosp Hangzhou City, Rehabil Ctr Brain Damage, Hangzhou, Zhejiang, Peoples R China 4.Univ Liege, Coma Sci Grp, Cyclotron Res Ctr, Liege, Belgium 5.Univ Liege, Dept Neurol, Liege, Belgium
第一作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	Qin, Pengmin,Di, Haibo,Yan, Xiaodan,et al. Mismatch negativity to the patient's own name in chronic disorders of consciousness[J]. NEUROSCIENCE LETTERS,2008,448(1):24-28.
APA	Qin, Pengmin.,Di, Haibo.,Yan, Xiaodan.,Yuc, Senming.,Yu, Dan.,...&X. C. Weng.(2008).Mismatch negativity to the patient's own name in chronic disorders of consciousness.NEUROSCIENCE LETTERS,448(1),24-28.
MLA	Qin, Pengmin,et al."Mismatch negativity to the patient's own name in chronic disorders of consciousness".NEUROSCIENCE LETTERS 448.1(2008):24-28.

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