Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
| Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio | |
Dong, Zhifang1,2; Zhong, Weixia3; Tian, Meng1,2; Han, Huili1,2; Mao, Rongrong1,2; Cao, Jun1,2; Sui, Nan4 ; Xu, Tianle5; Luo, Jianhong3; Xu, Lin1,2,6; Lin Xua
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| 摘要 | Repeated low-dose morphine treatment facilitates delayed-escape behaviour of hippocampus-dependent Morris water maze and morphine withdrawal influences hippocampal NMDA receptor-dependent synaptic plasticity. Here, we examined whether and how morphine withdrawal influenced delayed-escape behaviour and NR2A/2B expression ratio of hippocampal synaptosomes. We found that both delayed-escape behaviour and NR2A/2B expression ratio showed an inverted-U curve and peaked on 4-day withdrawal during a 20-day withdrawal period. Furthermore, treatment of the glucocorticoid receptor antagonist RU38486 for 3 days reduced delayed-escape behaviour and NR2A/2B ratio on 4-day withdrawal to a level similar to those of 18-h withdrawal. In contrast, elevated-platform stress enabled delayed-escape behaviour of 18-h withdrawal to a higher level similar to that of 4-day withdrawal, but had no significant effect on the NR2A/2B ratio. Similar behavioural effects were also found after intrahippocampal infusions of the NMDAR antagonist AP-5 or NR2B-containing NMDAR antagonist Ro25-6981 for 3 days. These findings suggest that delayed-escape behaviour enabled by repeated low-dose morphine treatment may be a useful and simple rat model for studying addictive memories to be retrieved by stress exposure.; Repeated low-dose morphine treatment facilitates delayed-escape behaviour of hippocampus-dependent Morris water maze and morphine withdrawal influences hippocampal NMDA receptor-dependent synaptic plasticity. Here, we examined whether and how morphine withdrawal influenced delayed-escape behaviour and NR2A/2B expression ratio of hippocampal synaptosomes. We found that both delayed-escape behaviour and NR2A/2B expression ratio showed an inverted-U curve and peaked on 4-day withdrawal during a 20-day withdrawal period. Furthermore, treatment of the glucocorticoid receptor antagonist RU38486 for 3 days reduced delayed-escape behaviour and NR2A/2B ratio on 4-day withdrawal to a level similar to those of 18-h withdrawal. In contrast, elevated-platform stress enabled delayed-escape behaviour of 18-h withdrawal to a higher level similar to that of 4-day withdrawal, but had no significant effect on the NR2A/2B ratio. Similar behavioural effects were also found after intrahippocampal infusions of the NMDAR antagonist AP-5 or NR2B-containing NMDAR antagonist Ro25-6981 for 3 days. These findings suggest that delayed-escape behaviour enabled by repeated low-dose morphine treatment may be a useful and simple rat model for studying addictive memories to be retrieved by stress exposure. (C) 2008 Elsevier B.V. All rights reserved. |
| 关键词 | opiate withdrawal stress delayed-escape behaviour long-term potentiation NR2A NR2B hippocampus |
| 学科领域 | 生理心理学/生物心理学 |
| 2008-05-01 | |
| 语种 | 英语 |
| 发表期刊 | BRAIN RESEARCH
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| ISSN | 0006-8993 |
| 卷号 | 1207页码:164-173 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| WOS记录号 | WOS:000255729200017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/5557 |
| 专题 | 中国科学院心理研究所回溯数据库(1956-2010) |
| 通讯作者 | Lin Xua |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Kunming 650223, Peoples R China 3.Zhejiang Univ, Sch Med, Dept Neurobiol, Hangzhou 310006, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China 6.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Zhifang,Zhong, Weixia,Tian, Meng,et al. Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio[J]. BRAIN RESEARCH,2008,1207:164-173. |
| APA | Dong, Zhifang.,Zhong, Weixia.,Tian, Meng.,Han, Huili.,Mao, Rongrong.,...&Lin Xua.(2008).Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio.BRAIN RESEARCH,1207,164-173. |
| MLA | Dong, Zhifang,et al."Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio".BRAIN RESEARCH 1207(2008):164-173. |
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