MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium
Zhu, Xinxing2,3; Chang, Suhua3; Fang, Kechi3; Cui, Sijia3; Liu, Jun4; Wu, Zuowei1; Yu, Xuping5; Gao, George F.1; Yang, Huanming6; Zhu, Baoli1; Wang, Jing3; Jing Wang
2009-02-20
发表期刊BMC MICROBIOLOGY
ISSN1471-2180
文章类型Article
卷号9
摘要Background: Mycobacterial pathogens are a major threat to humans. With the increasing availability of functional genomic data, research on mycobacterial pathogenesis and subsequent control strategies will be greatly accelerated. It has been suggested that genome polymorphisms, namely large sequence polymorphisms, can influence the pathogenicity of different mycobacterial strains. However, there is currently no database dedicated to mycobacterial genome polymorphisms with functional interpretations. Description: We have developed a mycobacterial database (MyBASE) housing genome polymorphism data and gene functions to provide the mycobacterial research community with a useful information resource and analysis platform. Whole genome comparison data produced by our lab and the novel genome polymorphisms identified were deposited into MyBASE. Extensive literature review of genome polymorphism data, mainly large sequence polymorphisms (LSPs), operon predictions and curated annotations of virulence and essentiality of mycobacterial genes are unique features of MyBASE. Large-scale genomic data integration from public resources makes MyBASE a comprehensive data warehouse useful for current research. All data is cross-linked and can be graphically viewed via a toolbox in MyBASE. Conclusion: As an integrated platform focused on the collection of experimental data from our own lab and published literature, MyBASE will facilitate analysis of genome structure and polymorphisms, which will provide insight into genome evolution. Importantly, the database will also facilitate the comparison of virulence factors among various mycobacterial strains.; Background: Mycobacterial pathogens are a major threat to humans. With the increasing availability of functional genomic data, research on mycobacterial pathogenesis and subsequent control strategies will be greatly accelerated. It has been suggested that genome polymorphisms, namely large sequence polymorphisms, can influence the pathogenicity of different mycobacterial strains. However, there is currently no database dedicated to mycobacterial genome polymorphisms with functional interpretations.
学科领域系统生物学/生物信息学
收录类别SCI
语种英语
WOS记录号WOS:000265028300001
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5559
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者Jing Wang
作者单位1.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China
2.Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310007, Zhejiang, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China
4.Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
5.Zhejiang Univ, Coll Anim Sci, Inst Prevent Vet Med, Hangzhou 310029, Zhejiang, Peoples R China
6.Chinese Acad Sci, Beijing Inst Genom, Beijing 100029, Peoples R China
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Zhu, Xinxing,Chang, Suhua,Fang, Kechi,et al. MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium[J]. BMC MICROBIOLOGY,2009,9.
APA Zhu, Xinxing.,Chang, Suhua.,Fang, Kechi.,Cui, Sijia.,Liu, Jun.,...&Jing Wang.(2009).MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium.BMC MICROBIOLOGY,9.
MLA Zhu, Xinxing,et al."MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium".BMC MICROBIOLOGY 9(2009).
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