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Neural activity associated with cognitive regulation in heroin users: A fMRI study
Lee, TMC; Zhou, WH; Luo, XJ; Yuen, KSL; Ruan, XZ; Weng, XC; Tatia M.C. Lee
2005-07-15
Source PublicationNEUROSCIENCE LETTERS
ISSN0304-3940
SubtypeArticle
Volume382Issue:3Pages:211-216
AbstractPrevious research has found heroin addicts to be impulsive. This study employed functional magnetic resonance imaging technology to investigate the differences between heroin addicts and normal controls in neural activity associated with cognitive regulation of behavior. Twenty-one Chinese men participated in this study, 11 of whom were newly admitted heroin-addicted patients and 10 of whom were healthy volunteers. In the experimental task, the subjects were required to first identify the correct directions of arrowheads and then give the opposite answers. Behaviorally, the heroin-dependent patients took a much shorter time to complete the more demanding second part of the task but committed more errors than the normal controls. This pattern of behavior, characteristic of people who are disinhibited and who tend to be impulsive, was consistent with previous reports of impulsivity observed in people who have abused heroin. The neural activity of the patients that was associated with performing the experimental task of cognitive regulation was different to that of the normal controls in terms of the pattern of prefrontal activation, the attenuation of activity in the anterior cingulate, and the additional recruitment of the fight inferior parietal region. This study is the first that seeks to understand the neural activity associated with impulsive behavior in people who abuse heroin. The pattern of imaging data obtained resembled the pattern of data observed in immature brains attempting to exercise cognitive control of behavior. Further theoretical and clinical implications of the findings are discussed.; Previous research has found heroin addicts to be impulsive. This study employed functional magnetic resonance imaging technology to investigate the differences between heroin addicts and normal controls in neural activity associated with cognitive regulation of behavior. Twenty-one Chinese men participated in this study, 11 of whom were newly admitted heroin-addicted patients and 10 of whom were healthy volunteers. In the experimental task, the subjects were required to first identify the correct directions of arrowheads and then give the opposite answers. Behaviorally, the heroin-dependent patients took a much shorter time to complete the more demanding second part of the task but committed more errors than the normal controls. This pattern of behavior, characteristic of people who are disinhibited and who tend to be impulsive, was consistent with previous reports of impulsivity observed in people who have abused heroin. The neural activity of the patients that was associated with performing the experimental task of cognitive regulation was different to that of the normal controls in terms of the pattern of prefrontal activation, the attenuation of activity in the anterior cingulate, and the additional recruitment of the fight inferior parietal region. This study is the first that seeks to understand the neural activity associated with impulsive behavior in people who abuse heroin. The pattern of imaging data obtained resembled the pattern of data observed in immature brains attempting to exercise cognitive control of behavior. Further theoretical and clinical implications of the findings are discussed. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Keywordheroin fMRI impulsive behavior addiction inhibition opioid cognitive regulation
Subject Area认知神经科学
Indexed BySCI
Language英语
WOS IDWOS:000230065800003
Citation statistics
Cited Times:85[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5561
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorTatia M.C. Lee
Affiliation1.Univ Hong Kong, Neuropsychol Lab, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, Inst Clin Neuropsychol, Hong Kong, Hong Kong, Peoples R China
3.MacLehose Med Rehabil Ctr, Hong Kong, Hong Kong, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100864, Peoples R China
Recommended Citation
GB/T 7714
Lee, TMC,Zhou, WH,Luo, XJ,et al. Neural activity associated with cognitive regulation in heroin users: A fMRI study[J]. NEUROSCIENCE LETTERS,2005,382(3):211-216.
APA Lee, TMC.,Zhou, WH.,Luo, XJ.,Yuen, KSL.,Ruan, XZ.,...&Tatia M.C. Lee.(2005).Neural activity associated with cognitive regulation in heroin users: A fMRI study.NEUROSCIENCE LETTERS,382(3),211-216.
MLA Lee, TMC,et al."Neural activity associated with cognitive regulation in heroin users: A fMRI study".NEUROSCIENCE LETTERS 382.3(2005):211-216.
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