Neuroimaging activation studies in the vegetative state: predictors of recovery?
Di, Haibo1,2,3; Boly, Melanie1,2; Weng, Xuchu4; Ledoux, Didier1,2; Laureys, Steven1,2
2008-10-01
发表期刊CLINICAL MEDICINE
ISSN1470-2118
文章类型Article
卷号8期号:5页码:502-507
摘要The vegetative state (VS) is a devastating clinical condition characterised by wakefulness without awareness. Functional neuroimaging permits to objectively measure brain responsiveness to external stimuli in VS. The literature on functional magnetic resonance imaging and positron emission tomography studies in these patients has been reviewed. Results from 15 studies were classified in: absent cortical activation or 'typical' activation of 'low level' primary sensory cortices and 'atypical' activation spreading to 'higher level' associative cortices. This descriptive review on 48 published cases suggests that 'atypical' activation patterns seem to herald recovery from VS with a 93% specificity and 69% sensitivity. Passive stimulation paradigms, however, do not permit to make strong claims about the absence or presence of consciousness. Recently proposed mental imagery paradigms permit to identify signs of consciousness in non-communicative brain damaged patients. The clinical application of these functional neuroimaging techniques awaits validation from ongoing multi-centric cohort studies in these challenging patients with chronic disorders of consciousness.; The vegetative state (VS) is a devastating clinical condition characterised by wakefulness without awareness. Functional neuroimaging permits to objectively measure brain responsiveness to external stimuli in VS. The literature on functional magnetic resonance imaging and positron emission tomography studies in these patients has been reviewed. Results from 15 studies were classified in: absent cortical activation or 'typical' activation of 'low level' primary sensory cortices and 'atypical' activation spreading to 'higher level' associative cortices. This descriptive review on 48 published cases suggests that 'atypical' activation patterns seem to herald recovery from VS with a 93% specificity and 69% sensitivity. Passive stimulation paradigms, however, do not permit to make strong claims about the absence or presence of consciousness. Recently proposed mental imagery paradigms permit to identify signs of consciousness in non-communicative brain damaged patients. The clinical application of these functional neuroimaging techniques awaits validation from ongoing multi-centric cohort studies in these challenging patients with chronic disorders of consciousness.
关键词brain injury coma functional magnetic resonance imaging minimally conscious state positron emission tomography vegetative state
学科领域医学心理学 ; 认识神经科学
收录类别SCI
语种英语
WOS记录号WOS:000260039700009
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5579
专题中国科学院心理研究所回溯数据库(1956-2010)
作者单位1.Univ Liege, Coma Sci Grp, Cyclotron Res Ctr, B-4000 Liege, Belgium
2.Univ Liege, Dept Neurol, B-4000 Liege, Belgium
3.Hangzhou Normal Univ, Hangzhou, Zhejiang, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
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Di, Haibo,Boly, Melanie,Weng, Xuchu,et al. Neuroimaging activation studies in the vegetative state: predictors of recovery?[J]. CLINICAL MEDICINE,2008,8(5):502-507.
APA Di, Haibo,Boly, Melanie,Weng, Xuchu,Ledoux, Didier,&Laureys, Steven.(2008).Neuroimaging activation studies in the vegetative state: predictors of recovery?.CLINICAL MEDICINE,8(5),502-507.
MLA Di, Haibo,et al."Neuroimaging activation studies in the vegetative state: predictors of recovery?".CLINICAL MEDICINE 8.5(2008):502-507.
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