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Neuroimaging activation studies in the vegetative state: predictors of recovery?
Di, Haibo1,2,3; Boly, Melanie1,2; Weng, Xuchu4; Ledoux, Didier1,2; Laureys, Steven1,2
2008-10-01
Source PublicationCLINICAL MEDICINE
ISSN1470-2118
SubtypeArticle
Volume8Issue:5Pages:502-507
AbstractThe vegetative state (VS) is a devastating clinical condition characterised by wakefulness without awareness. Functional neuroimaging permits to objectively measure brain responsiveness to external stimuli in VS. The literature on functional magnetic resonance imaging and positron emission tomography studies in these patients has been reviewed. Results from 15 studies were classified in: absent cortical activation or 'typical' activation of 'low level' primary sensory cortices and 'atypical' activation spreading to 'higher level' associative cortices. This descriptive review on 48 published cases suggests that 'atypical' activation patterns seem to herald recovery from VS with a 93% specificity and 69% sensitivity. Passive stimulation paradigms, however, do not permit to make strong claims about the absence or presence of consciousness. Recently proposed mental imagery paradigms permit to identify signs of consciousness in non-communicative brain damaged patients. The clinical application of these functional neuroimaging techniques awaits validation from ongoing multi-centric cohort studies in these challenging patients with chronic disorders of consciousness.; The vegetative state (VS) is a devastating clinical condition characterised by wakefulness without awareness. Functional neuroimaging permits to objectively measure brain responsiveness to external stimuli in VS. The literature on functional magnetic resonance imaging and positron emission tomography studies in these patients has been reviewed. Results from 15 studies were classified in: absent cortical activation or 'typical' activation of 'low level' primary sensory cortices and 'atypical' activation spreading to 'higher level' associative cortices. This descriptive review on 48 published cases suggests that 'atypical' activation patterns seem to herald recovery from VS with a 93% specificity and 69% sensitivity. Passive stimulation paradigms, however, do not permit to make strong claims about the absence or presence of consciousness. Recently proposed mental imagery paradigms permit to identify signs of consciousness in non-communicative brain damaged patients. The clinical application of these functional neuroimaging techniques awaits validation from ongoing multi-centric cohort studies in these challenging patients with chronic disorders of consciousness.
Keywordbrain injury coma functional magnetic resonance imaging minimally conscious state positron emission tomography vegetative state
Subject Area医学心理学 ; 认识神经科学
Indexed BySCI
Language英语
WOS IDWOS:000260039700009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5579
Collection中国科学院心理研究所回溯数据库(1956-2010)
Affiliation1.Univ Liege, Coma Sci Grp, Cyclotron Res Ctr, B-4000 Liege, Belgium
2.Univ Liege, Dept Neurol, B-4000 Liege, Belgium
3.Hangzhou Normal Univ, Hangzhou, Zhejiang, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Di, Haibo,Boly, Melanie,Weng, Xuchu,et al. Neuroimaging activation studies in the vegetative state: predictors of recovery?[J]. CLINICAL MEDICINE,2008,8(5):502-507.
APA Di, Haibo,Boly, Melanie,Weng, Xuchu,Ledoux, Didier,&Laureys, Steven.(2008).Neuroimaging activation studies in the vegetative state: predictors of recovery?.CLINICAL MEDICINE,8(5),502-507.
MLA Di, Haibo,et al."Neuroimaging activation studies in the vegetative state: predictors of recovery?".CLINICAL MEDICINE 8.5(2008):502-507.
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