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Neurological abnormalities in Chinese schizophrenic patients
Chan, Raymond C. K.; Chen, Eric Y. H.; R. C. K. Chan
2007
Source PublicationBEHAVIOURAL NEUROLOGY
ISSN0953-4180
SubtypeArticle
Volume18Issue:3Pages:171-181
AbstractBackground: This study attempted to examine the prevalence and type of neurological signs in Chinese patients with schizophrenia. Methods: A cross-sectional design was adopted with the use of the Cambridge Neurological Inventory (CNI). The CNI is comprised of 7 subscales, including motor coordination, sensory integration, disinhibition, extrapyramidal signs, dyskinesia, catatonia, and pyramidal signs. The former 3 subscales were classified as soft signs, whereas the latter 4 subscales were classified as hard signs. A total of 250 Chinese schizophrenic patients and 90 normal controls were recruited. Results: Patients exhibited significantly more signs than normal controls in all subscales but pyramidal signs (p < 0.00005). Significant differences were also found in total soft signs, total hard signs as well as total neurological signs (p < 0.0005). The three subscales of soft signs showed a relatively better sensitivity and specificity as compared with the four subscales of hard signs. Improvement in sensitivity and specificity was demonstrated when the subscales were collapsed into total soft signs, total hard signs and total neurological signs. A cut-off of 4 in total soft signs yields a sensitivity of 0:63 and specificity of 0.71; whereas a cut-off of I in total hard signs yields a sensitivity of 0.78 and specificity of 0.89. A global cut-off of 5 in total neurological signs results in a sensitivity of 0.81 and specificity of 0.73 for detecting schizophrenia versus normal. Conclusions: High levels of neurological abnormality characterize schizophrenic patients. An extended assessment battery of CNI provides even better discrimination of patients from normal controls, and soft signs are more strongly associated with schizophrenia than are hard signs in the Chinese sample.; Background: This study attempted to examine the prevalence and type of neurological signs in Chinese patients with schizophrenia.
Keywordneurological signs prevalence Cambridge neurological inventory schizophrenia Chinese
Subject Area精神病学
Indexed BySCI
Language英语
WOS IDWOS:000249670900006
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5583
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorR. C. K. Chan
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Chan, Raymond C. K.,Chen, Eric Y. H.,R. C. K. Chan. Neurological abnormalities in Chinese schizophrenic patients[J]. BEHAVIOURAL NEUROLOGY,2007,18(3):171-181.
APA Chan, Raymond C. K.,Chen, Eric Y. H.,&R. C. K. Chan.(2007).Neurological abnormalities in Chinese schizophrenic patients.BEHAVIOURAL NEUROLOGY,18(3),171-181.
MLA Chan, Raymond C. K.,et al."Neurological abnormalities in Chinese schizophrenic patients".BEHAVIOURAL NEUROLOGY 18.3(2007):171-181.
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