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Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design
Chan, Raymond C. K.1,2,3; Wang, Ya1,2; Wang, Li2; Chen, Eric Y. H.3; Manschreck, Theo C.4; Li, Zhan-jiang5; Yu, Xin6; Gong, Qi-yong7; R. C. K. Chan
2009-12-24
Source PublicationPLOS ONE
ISSN1932-6203
SubtypeArticle
Volume4Issue:12
AbstractBackground: Neurological soft signs and neurocognitive impairments have long been considered important features of schizophrenia. Previous correlational studies have suggested that there is a significant relationship between neurological soft signs and neurocognitive functions. The purpose of the current study was to examine the underlying relationships between these two distinct constructs with structural equation modeling (SEM). Methods: 118 patients with schizophrenia and 160 healthy controls were recruited for the current study. The abridged version of the Cambridge Neurological Inventory (CNI) and a set of neurocognitive function tests were administered to all participants. SEM was then conducted independently in these two samples to examine the relationships between neurological soft signs and neurocognitive functions. Results: Both the measurement and structural models showed that the models fit well to the data in both patients and healthy controls. The structural equations also showed that there were modest to moderate associations among neurological soft signs, executive attention, verbal memory, and visual memory, while the healthy controls showed more limited associations. Conclusions: The current findings indicate that motor coordination, sensory integration, and disinhibition contribute to the latent construct of neurological soft signs, whereas the subset of neurocognitive function tests contribute to the latent constructs of executive attention, verbal memory, and visual memory in the present sample. Greater evidence of neurological soft signs is associated with more severe impairment of executive attention and memory functions. Clinical and theoretical implications of the model findings are discussed.; Background: Neurological soft signs and neurocognitive impairments have long been considered important features of schizophrenia. Previous correlational studies have suggested that there is a significant relationship between neurological soft signs and neurocognitive functions. The purpose of the current study was to examine the underlying relationships between these two distinct constructs with structural equation modeling (SEM).
Keywordschizophrenic-patients neuropsychological performance sustained attention abnormalities dysfunction instrument activation inventory symptoms children
Subject Area精神病学
Indexed BySCI ; SSCI
Language英语
WOS IDWOS:000273104000026
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5585
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorR. C. K. Chan
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
4.Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
5.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
6.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
7.Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, W China Hosp,W China Sch Med, Chengdu 610064, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Chan, Raymond C. K.,Wang, Ya,Wang, Li,et al. Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design[J]. PLOS ONE,2009,4(12).
APA Chan, Raymond C. K..,Wang, Ya.,Wang, Li.,Chen, Eric Y. H..,Manschreck, Theo C..,...&R. C. K. Chan.(2009).Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design.PLOS ONE,4(12).
MLA Chan, Raymond C. K.,et al."Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design".PLOS ONE 4.12(2009).
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