Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design
	Chan, Raymond C. K.1,2,3 ; Wang, Ya1,2 ; Wang, Li2 ; Chen, Eric Y. H.3; Manschreck, Theo C.4; Li, Zhan-jiang 5; Yu, Xin 6; Gong, Qi-yong 7; R. C. K. Chan
摘要	Background: Neurological soft signs and neurocognitive impairments have long been considered important features of schizophrenia. Previous correlational studies have suggested that there is a significant relationship between neurological soft signs and neurocognitive functions. The purpose of the current study was to examine the underlying relationships between these two distinct constructs with structural equation modeling (SEM). Methods: 118 patients with schizophrenia and 160 healthy controls were recruited for the current study. The abridged version of the Cambridge Neurological Inventory (CNI) and a set of neurocognitive function tests were administered to all participants. SEM was then conducted independently in these two samples to examine the relationships between neurological soft signs and neurocognitive functions. Results: Both the measurement and structural models showed that the models fit well to the data in both patients and healthy controls. The structural equations also showed that there were modest to moderate associations among neurological soft signs, executive attention, verbal memory, and visual memory, while the healthy controls showed more limited associations. Conclusions: The current findings indicate that motor coordination, sensory integration, and disinhibition contribute to the latent construct of neurological soft signs, whereas the subset of neurocognitive function tests contribute to the latent constructs of executive attention, verbal memory, and visual memory in the present sample. Greater evidence of neurological soft signs is associated with more severe impairment of executive attention and memory functions. Clinical and theoretical implications of the model findings are discussed.; Background: Neurological soft signs and neurocognitive impairments have long been considered important features of schizophrenia. Previous correlational studies have suggested that there is a significant relationship between neurological soft signs and neurocognitive functions. The purpose of the current study was to examine the underlying relationships between these two distinct constructs with structural equation modeling (SEM).
关键词	schizophrenic-patients neuropsychological performance sustained attention abnormalities dysfunction instrument activation inventory symptoms children
学科领域	精神病学
	2009-12-24
语种	英语
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	4 期号:12
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS记录号	WOS:000273104000026
引用统计	被引频次：59[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/5585
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	R. C. K. Chan
作者单位	1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China 4.Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA 5.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China 6.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China 7.Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, W China Hosp,W China Sch Med, Chengdu 610064, Peoples R China
第一作者单位	认知与发展心理学研究室; 中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Chan, Raymond C. K.,Wang, Ya,Wang, Li,et al. Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design[J]. PLOS ONE,2009,4(12).
APA	Chan, Raymond C. K..,Wang, Ya.,Wang, Li.,Chen, Eric Y. H..,Manschreck, Theo C..,...&R. C. K. Chan.(2009).Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design.PLOS ONE,4(12).
MLA	Chan, Raymond C. K.,et al."Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design".PLOS ONE 4.12(2009).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Chan-2009-Neurologic（279KB）			开放获取	--	浏览下载