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Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?
Chan, Raymond C. K.1,2,3; Gottesman, Irving I.4,5; R. C. K. Chan
2008-07-01
Source PublicationNEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
ISSN0149-7634
SubtypeReview
Volume32Issue:5Pages:957-971
AbstractThe crucial role of neurological indicators in schizophrenia has been recognized as among the "target features" that encompass the idea that genetic and non-genetic processes lead to neurointegrative defects later manifested in neurocognitive systems. In addition, aberrant neurological indicators have also been suggested as potential endophenotypes in schizophrenia. In the current paper, we review evidence for the utility of quantifiable neurological soft signs as potential endophenotypes for schizophrenia spectrum disorders. We start by defining endophenotypes and justifying their utility. We highlight the key criteria that must be met for an endophenotype to be useful and assess the extent to which the manifestations of neurological soft signs meet these criteria. Finally, we recommend areas in which additional research should be done to further elucidate the potential use of neurological soft signs for schizophrenia research.; The crucial role of neurological indicators in schizophrenia has been recognized as among the "target features" that encompass the idea that genetic and non-genetic processes lead to neurointegrative defects later manifested in neurocognitive systems. In addition, aberrant neurological indicators have also been suggested as potential endophenotypes in schizophrenia. In the current paper, we review evidence for the utility of quantifiable neurological soft signs as potential endophenotypes for schizophrenia spectrum disorders. We start by defining endophenotypes and justifying their utility. We highlight the key criteria that must be met for an endophenotype to be useful and assess the extent to which the manifestations of neurological soft signs meet these criteria. Finally, we recommend areas in which additional research should be done to further elucidate the potential use of neurological soft signs for schizophrenia research. (C) 2008 Elsevier Ltd. All rights reserved.
Keywordneurological soft signs endophenotype schizophrenia
Subject Area精神病学
Indexed BySCI
Language英语
WOS IDWOS:000257276700005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5587
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorR. C. K. Chan
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
4.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA
5.Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Chan, Raymond C. K.,Gottesman, Irving I.,R. C. K. Chan. Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2008,32(5):957-971.
APA Chan, Raymond C. K.,Gottesman, Irving I.,&R. C. K. Chan.(2008).Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,32(5),957-971.
MLA Chan, Raymond C. K.,et al."Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 32.5(2008):957-971.
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