Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?
Chan, Raymond C. K.1,2,3; Gottesman, Irving I.4,5; R. C. K. Chan
2008-07-01
发表期刊NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
ISSN0149-7634
文章类型Review
卷号32期号:5页码:957-971
摘要The crucial role of neurological indicators in schizophrenia has been recognized as among the "target features" that encompass the idea that genetic and non-genetic processes lead to neurointegrative defects later manifested in neurocognitive systems. In addition, aberrant neurological indicators have also been suggested as potential endophenotypes in schizophrenia. In the current paper, we review evidence for the utility of quantifiable neurological soft signs as potential endophenotypes for schizophrenia spectrum disorders. We start by defining endophenotypes and justifying their utility. We highlight the key criteria that must be met for an endophenotype to be useful and assess the extent to which the manifestations of neurological soft signs meet these criteria. Finally, we recommend areas in which additional research should be done to further elucidate the potential use of neurological soft signs for schizophrenia research.; The crucial role of neurological indicators in schizophrenia has been recognized as among the "target features" that encompass the idea that genetic and non-genetic processes lead to neurointegrative defects later manifested in neurocognitive systems. In addition, aberrant neurological indicators have also been suggested as potential endophenotypes in schizophrenia. In the current paper, we review evidence for the utility of quantifiable neurological soft signs as potential endophenotypes for schizophrenia spectrum disorders. We start by defining endophenotypes and justifying their utility. We highlight the key criteria that must be met for an endophenotype to be useful and assess the extent to which the manifestations of neurological soft signs meet these criteria. Finally, we recommend areas in which additional research should be done to further elucidate the potential use of neurological soft signs for schizophrenia research. (C) 2008 Elsevier Ltd. All rights reserved.
关键词neurological soft signs endophenotype schizophrenia
学科领域精神病学
收录类别SCI
语种英语
WOS记录号WOS:000257276700005
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5587
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者R. C. K. Chan
作者单位1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
4.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA
5.Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA
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Chan, Raymond C. K.,Gottesman, Irving I.,R. C. K. Chan. Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2008,32(5):957-971.
APA Chan, Raymond C. K.,Gottesman, Irving I.,&R. C. K. Chan.(2008).Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,32(5),957-971.
MLA Chan, Raymond C. K.,et al."Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star?".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 32.5(2008):957-971.
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