New animal model of emotional stress: Behavioral, neuroendocrine and immunological consequences
Lin, WJ; Wang, WW; Shao, F; W. J. Lin
2003-08-01
发表期刊CHINESE SCIENCE BULLETIN
ISSN1001-6538
文章类型Article
卷号48期号:15页码:1565-1568
摘要This report describes a new model of emotional stress, which was induced by randomly giving an empty water bottle to rats during watering periods per day for 14 consecutive days. The behavioral, endocrinological and immunological consequences were investigated. The data showed that the emotional stress activated both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system, leading to the increased blood levels of corticosterone and catecholamine. It also elicited attacking and exploring behavior, suppressed the immune function of the rats, including leukocyte counts, weight of the spleen, and the level of specific anti-ovalbumin IgG antibody production. Presenting no water and no empty bottle to rats only evoked the exploring behavior, increased the corticosterone level and decreased the leukocyte counts. These findings demonstrate a role of psychological factors on behavioral, endocrinological and immunological functioning. The animal model described in the present study may serve as an analogue mimicking emotional stress experienced in humans (e.g. anger and/or anxiety), and may be useful for further studying the complex relationships among emotional stress, behavior, and immune function.; This report describes a new model of emotional stress, which was induced by randomly giving an empty water bottle to rats during watering periods per day for 14 consecutive days. The behavioral, endocrinological and immunological consequences were investigated. The data showed that the emotional stress activated both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system, leading to the increased blood levels of corticosterone and catecholamine. It also elicited attacking and exploring behavior, suppressed the immune function of the rats, including leukocyte counts, weight of the spleen, and the level of specific anti-ovalbumin IgG antibody production. Presenting no water and no empty bottle to rats only evoked the exploring behavior, increased the corticosterone level and decreased the leukocyte counts. These findings demonstrate a role of psychological factors on behavioral, endocrinological and immunological functioning. The animal model described in the present study may serve as an analogue mimicking emotional stress experienced in humans (e.g. anger and/or anxiety), and may be useful for further studying the complex relationships among emotional stress, behavior, and immune function.
关键词emotional stress model attacking corticosterone catechollamine immune function
学科领域生理心理学/生物心理学
收录类别SCI ; SSCI
语种英语
WOS记录号WOS:000184925400012
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5591
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者W. J. Lin
作者单位1.Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Peking Univ, Dept Psychol, Beijing 1000871, Peoples R China
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GB/T 7714
Lin, WJ,Wang, WW,Shao, F,et al. New animal model of emotional stress: Behavioral, neuroendocrine and immunological consequences[J]. CHINESE SCIENCE BULLETIN,2003,48(15):1565-1568.
APA Lin, WJ,Wang, WW,Shao, F,&W. J. Lin.(2003).New animal model of emotional stress: Behavioral, neuroendocrine and immunological consequences.CHINESE SCIENCE BULLETIN,48(15),1565-1568.
MLA Lin, WJ,et al."New animal model of emotional stress: Behavioral, neuroendocrine and immunological consequences".CHINESE SCIENCE BULLETIN 48.15(2003):1565-1568.
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