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New animal model of emotional stress: Behavioral, neuroendocrine and immunological consequences
Lin, WJ; Wang, WW; Shao, F; W. J. Lin
2003-08-01
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
SubtypeArticle
Volume48Issue:15Pages:1565-1568
AbstractThis report describes a new model of emotional stress, which was induced by randomly giving an empty water bottle to rats during watering periods per day for 14 consecutive days. The behavioral, endocrinological and immunological consequences were investigated. The data showed that the emotional stress activated both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system, leading to the increased blood levels of corticosterone and catecholamine. It also elicited attacking and exploring behavior, suppressed the immune function of the rats, including leukocyte counts, weight of the spleen, and the level of specific anti-ovalbumin IgG antibody production. Presenting no water and no empty bottle to rats only evoked the exploring behavior, increased the corticosterone level and decreased the leukocyte counts. These findings demonstrate a role of psychological factors on behavioral, endocrinological and immunological functioning. The animal model described in the present study may serve as an analogue mimicking emotional stress experienced in humans (e.g. anger and/or anxiety), and may be useful for further studying the complex relationships among emotional stress, behavior, and immune function.; This report describes a new model of emotional stress, which was induced by randomly giving an empty water bottle to rats during watering periods per day for 14 consecutive days. The behavioral, endocrinological and immunological consequences were investigated. The data showed that the emotional stress activated both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system, leading to the increased blood levels of corticosterone and catecholamine. It also elicited attacking and exploring behavior, suppressed the immune function of the rats, including leukocyte counts, weight of the spleen, and the level of specific anti-ovalbumin IgG antibody production. Presenting no water and no empty bottle to rats only evoked the exploring behavior, increased the corticosterone level and decreased the leukocyte counts. These findings demonstrate a role of psychological factors on behavioral, endocrinological and immunological functioning. The animal model described in the present study may serve as an analogue mimicking emotional stress experienced in humans (e.g. anger and/or anxiety), and may be useful for further studying the complex relationships among emotional stress, behavior, and immune function.
Keywordemotional stress model attacking corticosterone catechollamine immune function
Subject Area生理心理学/生物心理学
Indexed BySCI ; SSCI
Language英语
WOS IDWOS:000184925400012
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5591
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorW. J. Lin
Affiliation1.Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Peking Univ, Dept Psychol, Beijing 1000871, Peoples R China
Recommended Citation
GB/T 7714
Lin, WJ,Wang, WW,Shao, F,et al. New animal model of emotional stress: Behavioral, neuroendocrine and immunological consequences[J]. CHINESE SCIENCE BULLETIN,2003,48(15):1565-1568.
APA Lin, WJ,Wang, WW,Shao, F,&W. J. Lin.(2003).New animal model of emotional stress: Behavioral, neuroendocrine and immunological consequences.CHINESE SCIENCE BULLETIN,48(15),1565-1568.
MLA Lin, WJ,et al."New animal model of emotional stress: Behavioral, neuroendocrine and immunological consequences".CHINESE SCIENCE BULLETIN 48.15(2003):1565-1568.
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