Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood

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	Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood
	Zheng, XG; Tan, BP; Luo, XJ; Xu, W; Yang, XY; Sui, N; N. Sui
摘要	The relationship between motor responses in a novel environment and susceptibility to place conditioning effect of psychostimulants has been reported in adult rats. However, it is in question whether this correlation could be generalized to motor activity in rats of juvenile period and place conditioning effect in their adulthood for narcotic morphine. In the present study, we tested locomotor activity in an arena open-field and the subsequent novelty-seeking behavior after adaptation process in juvenile rats (P42) and morphine (2 mg/kg) place conditioning effect 56 days later in the same rats' adulthood (P98). Our results showed that rats with high response to novelty (HRN) spent more prolonged duration in the drug-paired compartment in the place conditioning test compared with their low response counterparts (LRN), with the latter group no salient change on this measure. Moreover, rats with high response to the open-field test (HRS) expressed equally elevated duration in drug-paired side relative to their low response counterparts (LRS). The present research demonstrated that novelty-seeking behavior and locomotor activity in the open-field in rats of juvenile period differentially related to morphine place conditioning in their adulthood, with slow acquisition of morphine place conditioning effect in LRN animals; The relationship between motor responses in a novel environment and susceptibility to place conditioning effect of psychostimulants has been reported in adult rats. However, it is in question whether this correlation could be generalized to motor activity in rats of juvenile period and place conditioning effect in their adulthood for narcotic morphine. In the present study, we tested locomotor activity in an arena open-field and the subsequent novelty-seeking behavior after adaptation process in juvenile rats (P42) and morphine (2 mg/kg) place conditioning effect 56 days later in the same rats' adulthood (P98). Our results showed that rats with high response to novelty (HRN) spent more prolonged duration in the drug-paired compartment in the place conditioning test compared with their low response counterparts (LRN), with the latter group no salient change on this measure. Moreover, rats with high response to the open-field test (HRS) expressed equally elevated duration in drug-paired side relative to their low response counterparts (LRS). The present research demonstrated that novelty-seeking behavior and locomotor activity in the open-field in rats of juvenile period differentially related to morphine place conditioning in their adulthood, with slow acquisition of morphine place conditioning effect in LRN animals. (C) 2003 Elsevier B.V. All rights reserved.
关键词	development morphine novelty seeking place conditioning stress
学科领域	医学心理学
	2004-01-30
语种	英语
发表期刊	BEHAVIOURAL PROCESSES
ISSN	0376-6357
卷号	65 期号:1 页码:15-23
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS记录号	WOS:000188861400003
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5593
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	N. Sui
作者单位	Acad Sinica, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zheng, XG,Tan, BP,Luo, XJ,et al. Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood[J]. BEHAVIOURAL PROCESSES,2004,65(1):15-23.
APA	Zheng, XG.,Tan, BP.,Luo, XJ.,Xu, W.,Yang, XY.,...&N. Sui.(2004).Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood.BEHAVIOURAL PROCESSES,65(1),15-23.
MLA	Zheng, XG,et al."Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood".BEHAVIOURAL PROCESSES 65.1(2004):15-23.

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