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Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene
Wan, C.; Zhang, T.; Wang, B.; Han, Y.; Zhang, C.; Zhang, Y.; Gong, H.; Jin, F.; Wang, L.; L. Wang; F. Jin
2006-11-01
Source PublicationDIABETES OBESITY & METABOLISM
ISSN1462-8902
SubtypeArticle
Volume8Issue:6Pages:703-708
AbstractBACKGROUND: Obesity is considered to be a multifactorial trait resulting from the combined influence of genetic and environmental determinants. Insulin resistance plays an important role in the development of obesity. Plasma-cell membrane differentiation antigene-1 (PC-1) inhibits insulin receptor signalling when overexpressed and thus causes insulin resistance. PC-1 gene polymorphism might be associated with adipocyte metabolism disturbance and energy imbalance. The purpose of this study was to determine whether K121Q polymorphism in PC-1 gene is involved in obesity susceptibility in Chinese Han population. METHODS: The genotype of the polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism analysis for 338 unrelated subjects of Beijing, China. Their Body mass index (BMI), plasma glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL), free fatty acid (FFA) and insulin level were measured. Chi-square analyses were applied to test the significance differences in genotypic and allelic frequencies. Association studies were undertaken using the t-test and logistic regression analyses. RESULTS: The obese had significantly higher frequency of KQ/QQ genotype or Q allele than non-obese in females (26.7% vs. 10.9%, p = 0.014 and 13.3% vs. 5.5%, p = 0.021). Significant elevation of insulin amongst the Q121 carrier women in obesity individuals and higher FFA level of Q121 carrier men in non-obese controls (BMI < or = 23 kg/m2) were observed. Binary logistic regression analysis revealed that PC-1 genotype together with higher glucose, total cholesterol, triglyceride and serum HDL were independently associated with the presence of obesity. CONCLUSIONS: The observed genotype distributions revealed a significant association of PC-1 K121Q with obesity. PC-1 Q121 carriers are more likely to be insulin-resistant or get fatter in respect to KK subjects and carriers of the Q allele are at higher risk for the development of obesity in female.; Background: Obesity is considered to be a multifactorial trait resulting from the combined influence of genetic and environmental determinants. Insulin resistance plays an important role in the development of obesity. Plasma-cell membrane differentiation antigene-1 (PC-1) inhibits insulin receptor signalling when overexpressed and thus causes insulin resistance. PC-1 gene polymorphism might be associated with adipocyte metabolism disturbance and energy imbalance. The purpose of this study was to determine whether K121Q polymorphism in PC-1 gene is involved in obesity susceptibility in Chinese Han population.
Keywordinsulin resistance obesity plasma-cell membrane differentiation antigene-1 polymorphism
Subject Area系统生物学/生物信息学
Indexed BySCI
Language英语
WOS IDWOS:000241033700014
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5597
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorL. Wang; F. Jin
Affiliation1.Chinese Acad Sci, Inst Genet & Dev Biol, Ctr Human & Anim Genet, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Minist Hlth PR China, Beijing Hosp, Inst Geriatr, Key Lab Geriatr, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Res Lab Behav Biol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wan, C.,Zhang, T.,Wang, B.,et al. Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene[J]. DIABETES OBESITY & METABOLISM,2006,8(6):703-708.
APA Wan, C..,Zhang, T..,Wang, B..,Han, Y..,Zhang, C..,...&F. Jin.(2006).Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene.DIABETES OBESITY & METABOLISM,8(6),703-708.
MLA Wan, C.,et al."Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene".DIABETES OBESITY & METABOLISM 8.6(2006):703-708.
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