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Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats
Li, YH; Zheng, XG; Bai, YJ; Yang, XY; Sui, N; N. Sui
2006
Source PublicationJOURNAL OF PSYCHOPHARMACOLOGY
ISSN0269-8811
SubtypeArticle
Volume20Issue:1Pages:40-46
AbstractBehavioural studies have provided strong evidence for common substrates in the rewards of natural and addictive substances, but it is still unclear whether there is a common glutamatergic NMDA receptor mechanism involved in the processing of reward for both. The present study was designed to investigate the effects of MK-801 (0.1mg/kg) on the expression of place preference conditioned with food and morphine (5.0mg/kg) in rats. The data indicates that MK-801 potentiates the expression of food-induced conditioned place preference (CPP) but retards that of morphine CPP. It also demonstrates that the opposite effects of MK-801 on food and morphine CPP expression were caused neither by hyperactivity nor by the impairment of memory retrieval. These results suggest that MK-801 enhances food craving and inhibits morphine craving in rats, and that the roles of glutamatergic NMDA receptor mechanisms in the reward processing of natural reinforcers and addictive drugs may be dissociable.; Behavioural studies have provided strong evidence for common substrates in the rewards of natural and addictive substances, but it is still unclear whether there is a common glutamatergic NMDA receptor mechanism involved in the processing of reward for both. The present study was designed to investigate the effects of MK-801 (0.1 mg/kg) on the expression of place preference conditioned with food and morphine (5.0 mg/kg) in rats. The data indicates that MK-801 potentiates the expression of food-induced conditioned place preference (CPP) but retards that of morphine CPP. It also demonstrates that the opposite effects of MK-801 on food and morphine CPP expression were caused neither by hyperactivity nor by the impairment of memory retrieval. These results suggest that MK-801 enhances food craving and inhibits morphine craving in rats, and that the roles of glutamatergic NMDA receptor mechanisms in the reward processing of natural reinforcers and addictive drugs may be dissociable.
KeywordMK-801 morphine food expression of CPP craving
Subject Area医学心理学
Indexed BySCI
Language英语
WOS IDWOS:000235451200006
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5601
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorN. Sui
Affiliation1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Lab Mental Hlth, Beijing, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li, YH,Zheng, XG,Bai, YJ,et al. Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2006,20(1):40-46.
APA Li, YH,Zheng, XG,Bai, YJ,Yang, XY,Sui, N,&N. Sui.(2006).Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats.JOURNAL OF PSYCHOPHARMACOLOGY,20(1),40-46.
MLA Li, YH,et al."Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats".JOURNAL OF PSYCHOPHARMACOLOGY 20.1(2006):40-46.
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