Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats | |
Li, YH; Zheng, XG; Bai, YJ; Yang, XY; Sui, N; N. Sui | |
摘要 | Behavioural studies have provided strong evidence for common substrates in the rewards of natural and addictive substances, but it is still unclear whether there is a common glutamatergic NMDA receptor mechanism involved in the processing of reward for both. The present study was designed to investigate the effects of MK-801 (0.1mg/kg) on the expression of place preference conditioned with food and morphine (5.0mg/kg) in rats. The data indicates that MK-801 potentiates the expression of food-induced conditioned place preference (CPP) but retards that of morphine CPP. It also demonstrates that the opposite effects of MK-801 on food and morphine CPP expression were caused neither by hyperactivity nor by the impairment of memory retrieval. These results suggest that MK-801 enhances food craving and inhibits morphine craving in rats, and that the roles of glutamatergic NMDA receptor mechanisms in the reward processing of natural reinforcers and addictive drugs may be dissociable.; Behavioural studies have provided strong evidence for common substrates in the rewards of natural and addictive substances, but it is still unclear whether there is a common glutamatergic NMDA receptor mechanism involved in the processing of reward for both. The present study was designed to investigate the effects of MK-801 (0.1 mg/kg) on the expression of place preference conditioned with food and morphine (5.0 mg/kg) in rats. The data indicates that MK-801 potentiates the expression of food-induced conditioned place preference (CPP) but retards that of morphine CPP. It also demonstrates that the opposite effects of MK-801 on food and morphine CPP expression were caused neither by hyperactivity nor by the impairment of memory retrieval. These results suggest that MK-801 enhances food craving and inhibits morphine craving in rats, and that the roles of glutamatergic NMDA receptor mechanisms in the reward processing of natural reinforcers and addictive drugs may be dissociable. |
关键词 | MK-801 morphine food expression of CPP craving |
学科领域 | 医学心理学 |
2006 | |
语种 | 英语 |
发表期刊 | JOURNAL OF PSYCHOPHARMACOLOGY |
ISSN | 0269-8811 |
卷号 | 20期号:1页码:40-46 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS记录号 | WOS:000235451200006 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/5601 |
专题 | 中国科学院心理研究所回溯数据库(1956-2010) |
通讯作者 | N. Sui |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Lab Mental Hlth, Beijing, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Li, YH,Zheng, XG,Bai, YJ,et al. Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2006,20(1):40-46. |
APA | Li, YH,Zheng, XG,Bai, YJ,Yang, XY,Sui, N,&N. Sui.(2006).Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats.JOURNAL OF PSYCHOPHARMACOLOGY,20(1),40-46. |
MLA | Li, YH,et al."Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats".JOURNAL OF PSYCHOPHARMACOLOGY 20.1(2006):40-46. |
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