Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats
Li, YH; Zheng, XG; Bai, YJ; Yang, XY; Sui, N; N. Sui
2006
发表期刊JOURNAL OF PSYCHOPHARMACOLOGY
ISSN0269-8811
文章类型Article
卷号20期号:1页码:40-46
摘要Behavioural studies have provided strong evidence for common substrates in the rewards of natural and addictive substances, but it is still unclear whether there is a common glutamatergic NMDA receptor mechanism involved in the processing of reward for both. The present study was designed to investigate the effects of MK-801 (0.1mg/kg) on the expression of place preference conditioned with food and morphine (5.0mg/kg) in rats. The data indicates that MK-801 potentiates the expression of food-induced conditioned place preference (CPP) but retards that of morphine CPP. It also demonstrates that the opposite effects of MK-801 on food and morphine CPP expression were caused neither by hyperactivity nor by the impairment of memory retrieval. These results suggest that MK-801 enhances food craving and inhibits morphine craving in rats, and that the roles of glutamatergic NMDA receptor mechanisms in the reward processing of natural reinforcers and addictive drugs may be dissociable.; Behavioural studies have provided strong evidence for common substrates in the rewards of natural and addictive substances, but it is still unclear whether there is a common glutamatergic NMDA receptor mechanism involved in the processing of reward for both. The present study was designed to investigate the effects of MK-801 (0.1 mg/kg) on the expression of place preference conditioned with food and morphine (5.0 mg/kg) in rats. The data indicates that MK-801 potentiates the expression of food-induced conditioned place preference (CPP) but retards that of morphine CPP. It also demonstrates that the opposite effects of MK-801 on food and morphine CPP expression were caused neither by hyperactivity nor by the impairment of memory retrieval. These results suggest that MK-801 enhances food craving and inhibits morphine craving in rats, and that the roles of glutamatergic NMDA receptor mechanisms in the reward processing of natural reinforcers and addictive drugs may be dissociable.
关键词MK-801 morphine food expression of CPP craving
学科领域医学心理学
收录类别SCI
语种英语
WOS记录号WOS:000235451200006
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5601
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者N. Sui
作者单位1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Lab Mental Hlth, Beijing, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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Li, YH,Zheng, XG,Bai, YJ,et al. Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2006,20(1):40-46.
APA Li, YH,Zheng, XG,Bai, YJ,Yang, XY,Sui, N,&N. Sui.(2006).Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats.JOURNAL OF PSYCHOPHARMACOLOGY,20(1),40-46.
MLA Li, YH,et al."Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats".JOURNAL OF PSYCHOPHARMACOLOGY 20.1(2006):40-46.
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