Orexin A attenuates unconditioned sexual motivation in male rats

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	Orexin A attenuates unconditioned sexual motivation in male rats
	Bai, Y. J.1,2; Li, Y. H.1; Zheng, X. G.1; Han, J.1,2; Yang, X. Y.1; Sui, N.1; N. Sui
	2009-02-01
发表期刊	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN	0091-3057
文章类型	Article
卷号	91 期号:4 页码:581-589
摘要	Orexins are neuropeptides involved in multiple neurophysiological functions such as reward and motivation. However, it is not clear whether orexins are implicated in sexual motivation. This study aims to evaluate the effects of orexin A and the OX1R antagonist SB334867 on unconditioned sexual motivation. Forty-five male Wistar rats are divided into four groups. The four groups are respectively administered intracerebroventricularly with saline, orexin A (1, 10 mu g), 10% DMSO (cyclodextrin) and SB334867 (5, 15 mu g) 10- 15 min before sexual motivation tests. The preference for a receptive female to a male in in open arena with two tethered animals is designated as unconditioned sexual motivation. The results show that orexin A reduces the female preference (reducing time in the female zone and/or increasing time in the male zone). the number of visits for the female zone and the total distance traveled in sexually high-motivated males. SB334867 has no effect on the female preference, the number of visits and the distance traveled in either sexually high-motivated or low-motivated males. Our experiments reveal that centrally administered orexin A attenuates sexual motivation in high-motivated males although endogenous orexin A might not play an important role in the expression of unconditioned sexual motivation.; Orexins are neuropeptides involved in multiple neurophysiological functions such as reward and motivation. However, it is not clear whether orexins are implicated in sexual motivation. This study aims to evaluate the effects of orexin A and the OX(1)R antagonist SB334867 on unconditioned sexual motivation. Forty-five male Wistar rats are divided into four groups. The four groups are respectively administered intracerebroventricularly with saline, orexin A (1, 10 mu g), 10% DMSO (cyclodextrin) and SB334867 (5, 15 mu g) 10- 15 min before sexual motivation tests. The preference for a receptive female to a male in in open arena with two tethered animals is designated as unconditioned sexual motivation. The results show that orexin A reduces the female preference (reducing time in the female zone and/or increasing time in the male zone). the number of visits for the female zone and the total distance traveled in sexually high-motivated males. SB334867 has no effect on the female preference, the number of visits and the distance traveled in either sexually high-motivated or low-motivated males. Our experiments reveal that centrally administered orexin A attenuates sexual motivation in high-motivated males although endogenous orexin A might not play an important role in the expression of unconditioned sexual motivation. (c) 2008 Elsevier Inc. All rights reserved.
关键词	Unconditioned sexual motivation Orexin Preference score Intracerebroventricle
学科领域	生理心理学/生物心理学
收录类别	SCI
语种	英语
WOS记录号	WOS:000263633900015
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5605
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	N. Sui
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Heath, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Bai, Y. J.,Li, Y. H.,Zheng, X. G.,et al. Orexin A attenuates unconditioned sexual motivation in male rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,91(4):581-589.
APA	Bai, Y. J..,Li, Y. H..,Zheng, X. G..,Han, J..,Yang, X. Y..,...&N. Sui.(2009).Orexin A attenuates unconditioned sexual motivation in male rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,91(4),581-589.
MLA	Bai, Y. J.,et al."Orexin A attenuates unconditioned sexual motivation in male rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 91.4(2009):581-589.

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