Orexin A attenuates unconditioned sexual motivation in male rats
Bai, Y. J.1,2; Li, Y. H.1; Zheng, X. G.1; Han, J.1,2; Yang, X. Y.1; Sui, N.1; N. Sui
2009-02-01
发表期刊PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN0091-3057
文章类型Article
卷号91期号:4页码:581-589
摘要Orexins are neuropeptides involved in multiple neurophysiological functions such as reward and motivation. However, it is not clear whether orexins are implicated in sexual motivation. This study aims to evaluate the effects of orexin A and the OX1R antagonist SB334867 on unconditioned sexual motivation. Forty-five male Wistar rats are divided into four groups. The four groups are respectively administered intracerebroventricularly with saline, orexin A (1, 10 mu g), 10% DMSO (cyclodextrin) and SB334867 (5, 15 mu g) 10- 15 min before sexual motivation tests. The preference for a receptive female to a male in in open arena with two tethered animals is designated as unconditioned sexual motivation. The results show that orexin A reduces the female preference (reducing time in the female zone and/or increasing time in the male zone). the number of visits for the female zone and the total distance traveled in sexually high-motivated males. SB334867 has no effect on the female preference, the number of visits and the distance traveled in either sexually high-motivated or low-motivated males. Our experiments reveal that centrally administered orexin A attenuates sexual motivation in high-motivated males although endogenous orexin A might not play an important role in the expression of unconditioned sexual motivation.; Orexins are neuropeptides involved in multiple neurophysiological functions such as reward and motivation. However, it is not clear whether orexins are implicated in sexual motivation. This study aims to evaluate the effects of orexin A and the OX(1)R antagonist SB334867 on unconditioned sexual motivation. Forty-five male Wistar rats are divided into four groups. The four groups are respectively administered intracerebroventricularly with saline, orexin A (1, 10 mu g), 10% DMSO (cyclodextrin) and SB334867 (5, 15 mu g) 10- 15 min before sexual motivation tests. The preference for a receptive female to a male in in open arena with two tethered animals is designated as unconditioned sexual motivation. The results show that orexin A reduces the female preference (reducing time in the female zone and/or increasing time in the male zone). the number of visits for the female zone and the total distance traveled in sexually high-motivated males. SB334867 has no effect on the female preference, the number of visits and the distance traveled in either sexually high-motivated or low-motivated males. Our experiments reveal that centrally administered orexin A attenuates sexual motivation in high-motivated males although endogenous orexin A might not play an important role in the expression of unconditioned sexual motivation. (c) 2008 Elsevier Inc. All rights reserved.
关键词Unconditioned sexual motivation Orexin Preference score Intracerebroventricle
学科领域生理心理学/生物心理学
收录类别SCI
语种英语
WOS记录号WOS:000263633900015
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/5605
专题中国科学院心理研究所回溯数据库(1956-2010)
通讯作者N. Sui
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Heath, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
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GB/T 7714
Bai, Y. J.,Li, Y. H.,Zheng, X. G.,et al. Orexin A attenuates unconditioned sexual motivation in male rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,91(4):581-589.
APA Bai, Y. J..,Li, Y. H..,Zheng, X. G..,Han, J..,Yang, X. Y..,...&N. Sui.(2009).Orexin A attenuates unconditioned sexual motivation in male rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,91(4),581-589.
MLA Bai, Y. J.,et al."Orexin A attenuates unconditioned sexual motivation in male rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 91.4(2009):581-589.
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